| Omega-3 (fish oil, krill oil, algal oil) | Irregular heart rhythm risk↓WorsenedForm tested: marine omega-3 fatty acids (formulation varied by trial) | Grade A | meta-analysis · n = 81,210 · 20215 graded rows for this goal |
| Calcium (carbonate vs citrate) | Blood pressure in people with normal blood pressure↓WorsenedForm tested: calcium supplementation or fortification | Grade A | systematic-review · n = 3,048 · 20152 graded rows for this goal |
| Folate (methylfolate vs folic acid) | Blood homocysteine by folic acid dose↓WorsenedForm tested: folic acid (with or without B12 or B6) | Grade A | meta-analysis · n = 2,596 · 20052 graded rows for this goal |
| Magnesium | Blood pressure↑ImprovedForm tested: Various oral forms | Grade A | meta-analysis · n = 2,028 · 20162 graded rows for this goal |
| Magnesium glycinate | Blood pressure↑ImprovedForm tested: Various oral forms | Grade A | meta-analysis · n = 2,028 · 2016 |
| Psyllium | LDL cholesterol, non-HDL cholesterol and apoB↓WorsenedForm tested: Psyllium (Plantago ovata) fiber | Grade A | meta-analysis · n = 1,924 · 20182 graded rows for this goal |
| Berberine (vs dihydroberberine) | Triglycerides↑ImprovedForm tested: berberine | Grade A | meta-analysis · n = 1,661 · 20232 graded rows for this goal |
| Potassium (chloride vs citrate vs gluconate) | Blood pressure in adults not on blood-pressure medicines↓WorsenedForm tested: potassium supplements (mostly potassium chloride, per ODS) | Grade A | meta-analysis · n = 917 · 20153 graded rows for this goal |
| Quercetin | Systolic and diastolic blood pressure↓WorsenedForm tested: Quercetin | Grade A | meta-analysis · n = 841 · 2022 |
| Vitamin C (ascorbic acid vs buffered vs liposomal) | Systolic blood pressure↓WorsenedForm tested: vitamin C alone | Grade B | meta-analysis · n = 890 · 2023 |
| Probiotics | Total and LDL cholesterol↓WorsenedForm tested: Various live-bacteria probiotic products (no prebiotics); strains varied | Grade C | meta-analysis · n = 1,624 · 2015 |
| Vitamin K2 (MK-7 vs MK-4) | Coronary artery calcium score progression (any vitamin K form)↑ImprovedForm tested: vitamin K (forms not specified in abstract) | Grade C | meta-analysis · n = 1,533 · 20232 graded rows for this goal |
| CoQ10 (ubiquinol vs ubiquinone) | Muscle symptoms in statin users?MixedForm tested: CoQ10 (form not specified in abstract) | Grade C | meta-analysis · n = 575 · 20183 graded rows for this goal |
| Fenugreek | Blood lipids (total and LDL cholesterol, triglycerides, HDL)↓WorsenedForm tested: Fenugreek (preparations varied by trial) | Grade C | meta-analysis · n = 560 · 20202 graded rows for this goal |
| Selenium (selenomethionine vs selenite) | Total and non-HDL cholesterol↓WorsenedForm tested: high-selenium yeast | Grade C | RCT · n = 394 · 2011 |
| Resveratrol | Blood pressure?MixedForm tested: Resveratrol | Grade C | meta-analysis · n = 247 · 2015 |
| Magnesium citrate | Arterial stiffness and blood pressure↔No effectForm tested: magnesium citrate (vs oxide, sulfate) | Grade C | RCT · n = 164 · 2022 |
| Vitamin B12 (methylcobalamin vs cyanocobalamin) | Major vascular events with homocysteine-lowering B vitamins↔No effectForm tested: vitamins B6, B9 (folic acid) and/or B12, alone or combined | No effect | meta-analysis · n = 71,422 · 2017 |
| Vitamin E (natural d-alpha vs synthetic dl-alpha tocopherol) | Major heart and blood-vessel events in healthy women (WHS)↔No effectForm tested: natural-source vitamin E | No effect | RCT · n = 39,876 · 20053 graded rows for this goal |
