Noni

Also called Morinda citrifolia, noni juice, noni fruit, Indian mulberry, morinda, Tahitian noni.

Best grade C across 4 graded outcomes Botanical Last checked Oct 21, 2026

The short answer

From 11 sources

Noni is a tropical fruit sold as juice and capsules for immunity and general health. NCCIH says it has not been shown to benefit any health condition in people. A few trials, often industry-funded, report lipid changes in smokers and modest effects on nausea and hangover markers. Rare liver-injury reports and high potassium are the main safety concerns.

Every graded outcome on this page

4 rows · line = participants

Grade CBlood lipids and hs-CRP in heavy smokersBlood lipidsn 132
Grade CNK cell activity and colds in adults with recurrent respiratory infectionsImmune markersn 84
Grade DPost-operative nausea and vomitingNausean 100
Grade DHangover symptoms and blood acetaldehyde after drinkingHangovern 30

Key facts

What it is: The fruit of Morinda citrifolia, a small evergreen tree of the Pacific Islands, Southeast Asia, Australia and India; its roots, bark, leaves and flowers have also been used traditionally¹
Agency verdict: NCCIH: noni has not been shown to have beneficial effects on any health condition in studies of people¹
Best-studied outcome: Blood lipids in 132 heavy smokers: 29.5 to 188 mL of juice a day for a month lowered cholesterol, triglycerides and hs-CRP vs a placebo juice (grade C; funded by juice maker Morinda Inc.)²
Liver: LiverTox describes a small number of isolated case reports of liver injury attributed to noni; NCCIH says it is unclear whether noni caused them^1,3
Potassium: Noni contains a substantial amount of potassium; NCCIH advises people with kidney disease or a potassium restriction to consult a provider first¹
Funding: The smoker lipid trial was funded by Morinda Inc., and the 96-person juice safety study was run by Tahitian Noni International research staff^2,4

What it is

Noni (Morinda citrifolia) is a small tropical evergreen tree whose fruit is sold as juice, fruit powder capsules and extracts.

How it works

Proposed

The smoker-trial authors link the lipid changes to iridoid glycosides in noni juice, which their placebo juice lacked. Laboratory research shows antioxidant and immune-modulating activity, but NCCIH notes these findings have not translated into proven benefits in people. All of these are proposed explanations.^1,2

Forms, side by side

3 forms named in our sources. The rest show what our data holds, and say plainly where it holds nothing yet.

Noni forms compared

3 forms

Noni forms compared: 3 forms by 3 attributes. Empty cells are labelled No data yet, or Not graded in the evidence row.
3 forms	Fruit juice	Dried fruit powder or extract capsules	Fermented noni polysaccharide extract
Absorption in people	No human absorption data in our sources.¹	Scopoletin, a noni fruit compound, was measurable in blood and urine in proportion to dose in a phase I study.⁸	No human absorption data in our sources.⁶
GI tolerance	NCCIH says juice might be safe for up to 3 months. A 28-day study in 96 healthy adults, run by the juice maker, found no clinically significant safety differences at up to 750 mL/day.^1,4	NCCIH: not enough reliable information to know whether noni fruit extract is safe. A phase I study in 51 people with advanced cancer found no dose-limiting toxicity up to 12 g/day.^1,8	No serious adverse events or treatment-related dropouts over 8 weeks at 975 mg/day.⁶
Studied for	Blood lipids in heavy smokers (29.5 to 188 mL/day)	Post-operative nausea (single 600 mg dose) and hangover markers (single 1 g dose)	NK cell activity in adults with recurrent colds (null primary result)

Noni fruit juice
Absorption in people
No human absorption data in our sources.¹
GI tolerance
NCCIH says juice might be safe for up to 3 months. A 28-day study in 96 healthy adults, run by the juice maker, found no clinically significant safety differences at up to 750 mL/day.^1,4
Studied for
Blood lipids in heavy smokers (29.5 to 188 mL/day)
Dried fruit powder or extract capsules
Absorption in people
Scopoletin, a noni fruit compound, was measurable in blood and urine in proportion to dose in a phase I study.⁸
GI tolerance
NCCIH: not enough reliable information to know whether noni fruit extract is safe. A phase I study in 51 people with advanced cancer found no dose-limiting toxicity up to 12 g/day.^1,8
Studied for
Post-operative nausea (single 600 mg dose) and hangover markers (single 1 g dose)
Fermented noni polysaccharide extract
Absorption in people
No human absorption data in our sources.⁶
GI tolerance
No serious adverse events or treatment-related dropouts over 8 weeks at 975 mg/day.⁶
Studied for
NK cell activity in adults with recurrent colds (null primary result)

What the human research says

Human trials only, one row per outcome. The form line shows what each trial actually tested. Grades follow our evidence-grading policy.

Trial map

4 graded outcomes, largest study first

4 graded outcomes: 2 improved, 1 mixed, 1 no effect. The largest, a 2012 randomized trial of 132 people on blood lipids and hs-CRP in heavy smokers, found an improvement.

By sizeTable

1Blood lipids and hs-CRP in heavy smokers

Improved · Grade C · RCT, 132 people, 2012

Adult heavy cigarette smokers (132 completed)

Dose, result and source

Every graded outcome on this page, largest study first
Outcome	Found	People	Study	Who was studied
Blood lipids and hs-CRP in heavy smokers	Improved	132	Grade C · RCT, 2012	Adult heavy cigarette smokers (132 completed)
Post-operative nausea and vomiting	Mixed	100	Grade D · RCT, 2010	Adults at high risk of post-operative nausea (ASA I-II), randomized to 4 arms
NK cell activity and colds in adults with recurrent respiratory infections	No effect	84	Grade C · RCT, 2026	Adults aged 40 to under 75 with 2 or more upper respiratory infections in the prior year (100 randomized, 84 analysed)
Hangover symptoms and blood acetaldehyde after drinking	Improved	30	Grade D · Crossover RCT, 2023	Healthy adults

Every graded row

4 rows

Form tested

Showing 4 of 4 outcomes. Human trials only.

Grade CBlood lipids and hs-CRP in heavy smokersBlood lipidsCholesterol, TG, hs-CRP lowerRCT
n 132 · 2012

Improved Noni juice significantly reduced total cholesterol, triglycerides and hs-CRP; LDL and homocysteine fell and HDL rose. The placebo juice did not significantly change lipids or hs-CRP.

Design: RCT, n = 132, 2012
Population: Adult heavy cigarette smokers (132 completed)
Form: Noni fruit juice vs a fruit-juice placebo without iridoids
Dose: 29.5 to 188 mL/day
Duration: 1 month
Source: Reference 2 · PubMed 23097636 (opens PubMed)

Grade CNK cell activity and colds in adults with recurrent respiratory infectionsImmune markersNot significantRCT
n 84 · 2026

No effect NK cell activity rose numerically more than with placebo, but the primary analysis was not statistically significant (p = 0.066 to 0.145); only per-protocol sensitivity analyses reached significance. Infection rates did not differ. No serious adverse events.

Design: RCT, n = 84, 2026
Population: Adults aged 40 to under 75 with 2 or more upper respiratory infections in the prior year (100 randomized, 84 analysed)
Form: Fermented noni polysaccharide extract tablets
Dose: 975 mg/day
Duration: 8 weeks
Source: Reference 6 · PubMed 42280334 (opens PubMed)

Grade DPost-operative nausea and vomitingNauseaEarly nausea 48% vs 80% (600 mg only)RCT
n 100 · 2010

Mixed Only the 600 mg dose reduced nausea in the first 6 hours (48% vs 80% with placebo, p = 0.04); other doses and later time periods did not differ from placebo. No side effects were reported.

Design: RCT, n = 100, 2010
Population: Adults at high risk of post-operative nausea (ASA I-II), randomized to 4 arms
Form: Dried noni fruit extract capsules
Dose: 150, 300 or 600 mg, single dose 1 hour before surgery
Duration: Single dose
Source: Reference 5 · PubMed 21294416 (opens PubMed)

Grade DHangover symptoms and blood acetaldehyde after drinkingHangoverImprovedCrossover RCT
n 30 · 2023

Improved Compared with placebo, peak blood alcohol came significantly earlier, and blood acetaldehyde and diarrhoea were lower at some time points. Lower acetaldehyde and milder hangover were seen mainly in subgroups (aged 36 or under, heavier drinkers).

Design: Crossover RCT, n = 30, 2023
Population: Healthy adults
Form: Noni fruit extract
Dose: 1 g, single dose
Duration: Single dose with alcohol
Source: Reference 7 · PubMed 36727425 (opens PubMed)

What the numbers add up to

Each point is worked out from the data and the sources numbered on this page, with the arithmetic shown under it. It adds no new data and is not medical advice.

One sponsor behind the juice data

The smoker lipid trial was funded by a noni juice maker, and the 96-person safety study was run by the maker's own research staff; none of our sources repeats the lipid result independently.^2,4

Studied doses

Doses used in research, shown against the official limits. They describe the studies, not a recommendation for you.

Studied doses in research, not advice. These are amounts used in research, not personal advice. Your clinician or pharmacist can say what fits you.

Doses studied in human trials

Doses studied in human trials ranged from a single 150 to 600 mg dose of dried noni fruit extract before surgery to 29.5 to 188 mL of juice a day for a month; a safety study used up to 750 mL of juice a day for 28 days, and a phase I study in people with cancer reached 12 g a day of capsules.^2,4,5,8

Interactions and safety

Published interactions only: each row cites a source. No row means none was found in our sources, not that a combination is safe.

What Noni meets

5 cited rows

Medicines 5

Noni5 medicines · 0 supplements

Supplements and foods 0

No supplement rows in our sources.

Reference summary
Case reports

Interactions

5 agents

Published interactions, grouped by kind
Agent	What the source says	Evidence
Medicines5
Medicines that increase potassium	NCCIH says it may be unsafe to combine noni with these; noni contains a substantial amount of potassium.¹	NIH fact sheet
Blood pressure-lowering medicines	NCCIH lists these among the medicines it may be unsafe to combine with noni.¹	NIH fact sheet
Medicines that can harm the liver	NCCIH lists these among the medicines it may be unsafe to combine with noni.¹	NIH fact sheet
Phenytoine.g. seizure medicine	A published case report described persistently low or undetectable phenytoin levels and poor seizure control in a man drinking noni juice daily; the authors suggested noni sped up phenytoin breakdown by CYP2C9.⁹	Case report
Warfarine.g. Coumadin	A 2004 case letter reported resistance to warfarin (Coumadin) in a person using noni.¹⁰	Case report

Check with what you take

Kept on this device only

Add what you take. We list every interaction our evidence profiles cite between Noni and your picks, and between your picks.

Add a supplement or medicine

Most cited:

Add a supplement or medicine you take to check it against Noni.

Starting from one medicine? The interaction checker rates how serious each pair is, on a curated list of 19 entries for 11 medicines. This cabinet has no severity rating: it lists every interaction row our supplement pages cite.

Who should be careful

4 groups

Kidney disease or potassium restriction: Noni contains a substantial amount of potassium; NCCIH advises people with kidney disease or who need to restrict potassium to consult a health care provider before using it.¹
Liver concerns: Several cases of liver toxicity have been reported in people who drank noni juice or tea for several weeks; it is unclear whether noni caused them. LiverTox describes a small number of isolated case reports.^1,3
Pregnancy and breastfeeding: NCCIH says little is known about whether noni is safe during pregnancy or while breastfeeding.¹
People on medicines: NCCIH advises anyone taking medicine to talk with a health care provider before using noni, since some herbs and medicines interact in harmful ways. Case reports describe noni lowering the effect of phenytoin and warfarin.^1,9,10

Liver

3 notes

Liver-injury reports are rare, but they are the main reason for caution.

Case reports: LiverTox records a small number of isolated case reports of clinically apparent liver injury attributed to noni.³
Causality: NCCIH notes the reported cases followed several weeks of noni juice or tea and that it is unclear whether noni caused the liver problems.¹
Skin products: A 2026 case report attributed cholestatic liver injury in a 60-year-old man to about 8 months of a noni-containing pain cream applied to the skin; liver tests returned to normal 6 months after discharge.¹¹

How to read the label

What to check on the Supplement Facts panel.

How to read the label

3 checks

Juice vs capsules

The lipid trial used 29.5 to 188 mL of juice a day; no lipid trial tested fruit powder capsules.²

Label dose vs clinical dose

Capsule-type trials used a single 600 mg dried-fruit extract dose (described as equivalent to 20 g of dried fruit) or a single 1 g fruit extract dose; fruit powder is not the same as an extract.^5,7

Fermented extracts are different

Fermented noni polysaccharide extract (975 mg/day in its trial) is a distinct ingredient from juice or fruit powder.⁶

Have the bottle? Photograph its Supplement Facts panel and see each line, noni included, beside the doses and forms the trials used in Label X-Ray.

Frequently asked questions

Short answers to common questions; the numbers link to the sources below.

Common questions

7 answers

Is noni juice good for you?

NCCIH says noni has not been shown to benefit any health condition in studies of people. One trial funded by a juice maker found lower cholesterol, triglycerides and hs-CRP in heavy smokers after a month.^1,2

Does noni help with hangovers?

One 30-person crossover study of a 1 g noni fruit extract found lower blood acetaldehyde at some time points, mainly in subgroups. The study was small and several authors work for a supplement manufacturer.⁷

Is noni bad for your liver?

Several liver-toxicity cases have been reported after weeks of noni juice or tea, though it is unclear whether noni caused them. LiverTox describes a small number of isolated reports.^1,3

How long is noni juice considered safe?

NCCIH says noni juice might be safe for up to 3 months, but there is not enough reliable information on noni fruit extract or on noni applied to the skin.¹

Does noni interact with medicines?

NCCIH says it may be unsafe with medicines that raise potassium, lower blood pressure or can harm the liver. Single case reports also describe lower phenytoin levels and warfarin resistance in people using noni.^1,9,10

Can I drink noni while pregnant or breastfeeding?

NCCIH says little is known about its safety during pregnancy or breastfeeding.¹

Who should be careful with noni?

People with kidney disease or a potassium restriction, and anyone taking medicines that raise potassium, lower blood pressure or can harm the liver, should talk with a health care provider first.¹

Sources

11 sources: trial abstracts, NIH fact sheets and reference databases. Numbers in the text link here.

Sources cited on this page

11 sources

1Noni: Usefulness and Safety (last updated February 2025)Fact sheet National Center for Complementary and Integrative Health (NCCIH), 2025 · nccih.nih.gov
2Noni juice improves serum lipid profiles and other risk markers in cigarette smokers.RCT ScientificWorldJournal, 2012 · PMID 23097636
3Noni. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury.Database National Institute of Diabetes and Digestive and Kidney Diseases, 2020 · PMID 31643695
4A double-blind clinical safety study of noni fruit juice.RCT Pac Health Dialog, 2009 · PMID 20443518
5Morinda citrifolia Linn. for prevention of postoperative nausea and vomiting.RCT J Med Assoc Thai, 2010 · PMID 21294416
6Fermented Noni Polysaccharides and Immune-Related Biomarkers in Adults with Recurrent URTIs: A Randomized, Double-Blind, Placebo-Controlled Trial.RCT Nutrients, 2026 · PMID 42280334
7Noni fruit extract ameliorates alcohol-induced hangover symptoms by reducing the concentrations of alcohol and acetaldehyde in a Sprague Dawley rat model and a human intervention study.Crossover RCT Food Funct, 2023 · PMID 36727425
8Using quality of life measures in a Phase I clinical trial of noni in patients with advanced cancer to select a Phase II dose.Open-label trial J Diet Suppl, 2009 · PMID 22435516
9Potentially Unsafe Herb-drug Interactions Between a Commercial Product of Noni Juice and Phenytoin- A Case Report.Observational Acta Neurol Taiwan, 2015 · PMID 26179835
10Coumadin resistance and the vitamin supplement "Noni".Observational Am J Hematol, 2004 · PMID 15307118
11A Case Report: Drug-Induced Liver Injury from Prolonged Topical Application of Noni (Morinda citrifolia).Observational J Investig Med High Impact Case Rep, 2026 · PMID 41805431

What changed

Every dated change to this page: what changed, who made it and why.

Change log

2 entries

Dated changes to this page
Date	Change	Who and why
Oct 21, 2026interactions, who should be careful, liver safety, FAQ	Re-checked the NCCIH noni page (February 2025) for the liver, potassium and kidney cautions. Added published case reports of noni with phenytoin (PMID 26179835) and warfarin (PMID 15307118), a 2026 liver-injury case after a noni skin cream (PMID 41805431), and two FAQs.	Writer: Kymata Health EditorialTrigger: A–Z page audit
Oct 15, 2026all	Initial editorial evidence review. Every PMID checked against NCBI E-utilities esummary (title and year) and each cited abstract read; numbers taken from the abstracts (and, where noted, the full text for funding and participant counts). Industry links disclosed: Morinda Inc. grant (2012 lipid trial), Tahitian Noni International authors (2009 safety study), NSTbio/Atomy/RnBS employees (2026 polysaccharide trial), COSMAX NS authors (2023 hangover study). Safety and interactions from NCCIH and LiverTox only. No product links, because of the safety concerns on this page.	Writer: Kymata Health EditorialTrigger: new page

Supplement & Nutrient Encyclopedia. Educational information only; it is not medical advice and does not replace a clinician. Dietary supplements are not intended to diagnose, treat, cure or prevent any disease. Statements about supplements have not been evaluated by the FDA.

Noni

Medicines 5

Supplements and foods 0

Blood pressure-lowering medicines

Medicines that can harm the liver

Medicines that increase potassium

Phenytoin

Warfarin