Pantethine
Summary
Pantethine is a vitamin B5 derivative. In a 32-person triple-blind trial, 600 to 900 mg a day lowered LDL cholesterol by about 11% over 16 weeks (grade D). A larger trial from the same group reported smaller drops of about 4 mg/dL. Evidence comes from few, small studies.
Key facts
- A dimer of pantetheine, the vitamin B5 unit used to build coenzyme A[1]
- LDL fell about 11% from baseline versus a 3% rise with placebo at 16 weeks[1]
- On top of a diet program, total cholesterol fell about 6 mg/dL and LDL about 4 mg/dL more than placebo[2]
- 1 graded human outcome on this page
- October 11, 2026
How it works
ProposedPantethine is a precursor of coenzyme A, which is involved in fat metabolism; how it lowers LDL in people is proposed rather than established.[1]
What the human research says
Human trials only, one row per outcome. The form column shows what each trial actually tested. Grades follow our evidence-grading policy.
| Outcome | Effect | Grade | Best evidence | PMID |
|---|---|---|---|---|
| LDL and total cholesterol | Improved | Grade D | RCT · n = 32 · 2014 Adults at low to moderate cardiovascular risk eligible for statins Form: Pantethine · Dose: 600 mg/day (weeks 1–8), then 900 mg/day (weeks 9–16) · Duration: 16 weeks LDL fell 11% from baseline versus a 3% rise with placebo, significant between groups at weeks 8 and 16; homocysteine did not change. | 24600231 (opens PubMed)Source [1] |
Forms
Studied doses
Doses studied in human trials ranged from 600 to 900 mg of pantethine a day (600 mg for 8 weeks, then 900 mg) over 16 weeks.[1][2]
Interactions
Published interactions only: each row cites a source. No row means none was found in our sources, not that a combination is safe.
None found in our sources.
Who should be careful
- People on statins or other lipid drugs
- The trials did not study pantethine together with statins or other lipid drugs.[1]
- Pregnancy and breastfeeding
- No safety data at supplement doses were found in the trials we cite.[1]
Talk to your pharmacist or clinician before starting a supplement, especially if you take prescription medicines.
Where to buy Pantethine
Products from brands we partner with that contain Pantethine. Listing a product is not a claim that it works; check the amount per serving against the doses studied above, and the label for other ingredients.
- SupersmartPaid linkPantethine3 capsules: 600 mg pantethine (from 1,092 mg Pantesin); 30 servingsShop at Supersmart (opens in new tab)Price and label checked 2026-10-11 on the brand’s site.
Partner links may earn us a commission. Learn more
Get 15% off with SMART026 (opens in new tab)15% off with code SMART026
Partner links may earn us a commission. Learn more
- Supersmart’s own terms and exclusions apply at checkout.
- 20% applies when 3 or more products ship on auto-delivery to the same address.
- The code discount and Subscribe & Save are separate offers; we don’t claim they combine.
- Offer terms from Supersmart’s site and its affiliate program, checked Oct 8, 2026. Offers can change; the brand's checkout is final.
Frequently asked questions
Does pantethine lower cholesterol?
Two small trials from one research group reported LDL drops of about 4 to 11% over 16 weeks.[1][2]
Is pantethine the same as vitamin B5?
It is a derivative of pantothenic acid (vitamin B5) used to make coenzyme A.[1]
Can it replace a statin?
No. The cholesterol drops were small, and statin users were not studied.[1]
Sources
- [1]Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation.. Vasc Health Risk Manag, 2014. RCT
- [2]Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation.. Nutr Res, 2011. RCT
What changed
- Effect arrows corrected on 1 row(s): outcomes where a harmful measure fell (pain, symptoms, blood pressure, lipids, glucose, risk) now show as improved (up). No study data changed.
- First draft. Every PMID checked against NCBI E-utilities (title, year and journal taken from the PubMed record) and abstracts read for each cited row. Product details in Where to buy read from the brand page on the date shown. Self-reviewed in a second strict pass (no independent reviewer yet).