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Zinc (gluconate or sulfate)
Modest help with inflammatory acne; people with acne tended to have lower blood zinc.
What the research shows: A 2020 meta-analysis found people with acne had lower blood zinc than controls, and people given zinc had fewer inflamed spots, with side effects similar to comparators. The trials were small and varied, and how zinc compares with standard acne treatments is not established. (PMID 32860489)
- Adult upper limit: 40 mg/day from all sources. Weeks of zinc at 50 mg/day or more can lower copper.
- Separate zinc from quinolone or tetracycline antibiotics, which are commonly used for acne.
In the studies
- The 2020 meta-analysis pooled oral and topical zinc trials in acne; doses varied and are not given in its abstract. Oral zinc above 40 mg a day exceeds the US upper limit.
A record of what researchers gave, in whom; not a dose for you.
EvidenceClimited (Grade C)
Quick pick · Momentous
Momentous Zinc, 60 capsules
1 capsule: 15 mg zinc (as zinc picolinate); 60 servings
$19.99price checked Oct 19, 2026 on Momentous’ site
- One-time
- $19.99
- Subscription
- $14.99
Also from our partners
L-OptiZinc 30 mgSupersmart
1 tablet: 30 mg elemental zinc as zinc L-methionine (L-OptiZinc); 120 servings
$23checked Oct 11, 2026 on Supersmart’s site
NOW Foods Zinc, 50 mg, 100 TabsHerbsPro
1 tablet: 50 mg zinc (as zinc gluconate)
50 mg per tablet, above the 40 mg adult upper limit.
$5.01checked Oct 14, 2026 on HerbsPro’s site
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