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Vitamin D3
Covers a common winter shortfall. For colds the benefit, if any, is small; the reason to take it is not running low.
What the research shows: A 2021 meta-analysis of 43 trials (48,488 people; PMID 33798465) found respiratory infections occurred slightly less often with vitamin D (61.3% vs 62.3% of people), with the clearest effect from daily doses of 400–1,000 IU. The 2025 update by the same group added three newer trials (61,589 people) and the effect was no longer statistically significant. Small at best, which is why this is a C. (PMID 33798465, PMID 39993397, PMID 28202713)
- Adult upper limit: 4,000 IU (100 mcg) a day from all sources (NIH Office of Dietary Supplements). More is not better and can raise blood calcium.
- Ask first with kidney disease, sarcoidosis or high calcium, or if you take thiazide diuretics, which together with vitamin D can raise calcium.
In the studies
- In the 2021 meta-analysis, the trials that showed a benefit gave daily vitamin D of 400–1,000 IU for 12 months or less.
A record of what researchers gave, in whom; not a dose for you.
EvidenceClimited (Grade C)
Quick pick · Momentous
Momentous Vitamin D3 2000 IU, 60 capsules
1 capsule: 50 mcg (2,000 IU) vitamin D3 as plant-based cholecalciferol, in extra virgin olive oil; 60 servings
$19.99price checked Oct 19, 2026 on Momentous’ site
- One-time
- $19.99
- Subscription
- $14.99
Also from our partners
Vitamin D3 1,000 IUSupersmart
1 softgel: 25 mcg (1,000 IU) vitamin D3; 150 servings
$17checked Oct 11, 2026 on Supersmart’s site
NOW Foods Vitamin D-3, 2000 IU, 30 SoftgelsHerbsPro
1 softgel: 50 mcg (2,000 IU) vitamin D3 (cholecalciferol, from lanolin)
$2.78checked Oct 14, 2026 on HerbsPro’s site
Dr. Tobias Vitamin D-3 5,000 IU (90 capsules)Dr. Tobias
1 capsule: 5,000 IU (125 mcg) vitamin D3; label directions 1 capsule daily
5,000 IU per capsule, above the 4,000 IU adult upper limit.
$17.99checked Oct 14, 2026 on Dr. Tobias’ site
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