Atorvastatin and supplements: 1 sourced interaction
Statin, also sold as Lipitor. Of these, 1 named by an FDA label or NIH page. Plus 1 predicted from how each works (not established). Plus 1 food and drink line. Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Atorvastatin with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
2Green tea (extract)Label or NIHAn NIH page names this pair (cause not established).
moderate · Named by an FDA label or NIH page · Cause not established
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Green tea extract can reduce blood levels of the cholesterol-lowering drug atorvastatin.”
- NIH National Center for Complementary and Integrative Health · Green Tea: Usefulness and Safety, What Do We Know About Safety?
- Checked Oct 25, 2026
St John's wortPredictedSt John's wort may lower Atorvastatin levels and effect: it speeds up CYP3A, an enzyme that breaks Atorvastatin down.
moderate · Predicted from how each works, not established · Breakdown by liver enzymes
Predicted from what each is known to do, not studied as a pair and not established.
St John's wort may lower Atorvastatin levels and effect: it speeds up CYP3A, an enzyme that breaks Atorvastatin down.
- FDA table of drugs that interact with CYP enzymes · St John's wort: CYP3A strong inducer (Table 1, row "St. John’s wort", column "CYP Strg IND" (footnote 18: The effect of St. John’s wort varies widely and is preparation dependent.))
- FDA table of drugs that interact with CYP enzymes · Atorvastatin: CYP3A substrate (Table 1, row "atorvastatin", column "CYP Mod SENS SUB")
- Checked Oct 23, 2026
Atorvastatin with food and drink
Food and drink
1GrapefruitLabel or NIHThe FDA label names this pair (breakdown by liver enzymes).
moderate · Named by an FDA label or NIH page · Breakdown by liver enzymes
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking LIPITOR”
“Grapefruit juice consumption, especially excessive consumption, more than 1.2 liters/daily, can raise the plasma levels of atorvastatin and may increase the risk of myopathy and rhabdomyolysis.”
“Avoid intake of large quantities of grapefruit juice, more than 1.2 liters daily, when taking LIPITOR.”
“Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking LIPITOR [see Drug Interactions (7.1)].”
- FDA drug label (DailyMed) · LIPITOR (ATORVASTATIN CALCIUM) TABLET, FILM COATED [VIATRIS SPECIALTY LLC], section 5.1
- Checked Oct 23, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Atorvastatin with everything else you take, together
Keep reading: Supplements and vitamins
Supplements and vitamins: every pageSupplement & Nutrient EncyclopediaBrowse all topics
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- Interaction MapCheck several medicines and supplements at once, each interaction sourced to PubMed, FDA labels or NIH; a pair we have no source for reads as not on our list, never as safe.
- St. John's wortSt.