Rosuvastatin and supplements: 1 sourced interaction
Statin, also sold as Crestor. Of these, 1 named by an FDA label or NIH page. Plus 3 predicted from how each works (not established). Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 23, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Rosuvastatin with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
1MagnesiumLabel or NIHThe FDA label names this pair (absorption in the gut).
moderate · Named by an FDA label or NIH page · Absorption in the gut
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“In patients taking an antacid, administer CRESTOR at least 2 hours before the antacid”
“Concomitant aluminum and magnesium hydroxide combination antacid administration decreased the mean exposure of rosuvastatin 50%”
“Concomitant aluminum and magnesium hydroxide combination antacid administration decreased the mean exposure of rosuvastatin 50% [see Clinical Pharmacology (12.3)].”
- FDA drug label (DailyMed) · CRESTOR (ROSUVASTATIN) TABLET, FILM COATED [ASTRAZENECA PHARMACEUTICALS LP], section 7.2
- Checked Oct 23, 2026
Minor
3CalciumPredictedTaken together, Calcium may cut how much Rosuvastatin is absorbed; spacing them apart is usually discussed.
minor · Predicted from how each works, not established · Absorption in the gut
Predicted from what each is known to do, not studied as a pair and not established.
Taken together, Calcium may cut how much Rosuvastatin is absorbed; spacing them apart is usually discussed.
- NIH Office of Dietary Supplements · Calcium: binds medicines in the gut (Office of Dietary Supplements · Calcium: Fact Sheet for Health Professionals, Interactions with Medications > Dolutegravir)
- FDA drug label (DailyMed) · Rosuvastatin: absorption affected by other products (CRESTOR (ROSUVASTATIN) TABLET, FILM COATED [ASTRAZENECA PHARMACEUTICALS LP], section 2.1)
- Checked Oct 23, 2026
IronPredictedTaken together, Iron may cut how much Rosuvastatin is absorbed; spacing them apart is usually discussed.
minor · Predicted from how each works, not established · Absorption in the gut
Predicted from what each is known to do, not studied as a pair and not established.
Taken together, Iron may cut how much Rosuvastatin is absorbed; spacing them apart is usually discussed.
- NIH Office of Dietary Supplements · Iron: binds medicines in the gut (Office of Dietary Supplements · Iron: Fact Sheet for Health Professionals, Interactions with Medications > Levodopa)
- FDA drug label (DailyMed) · Rosuvastatin: absorption affected by other products (CRESTOR (ROSUVASTATIN) TABLET, FILM COATED [ASTRAZENECA PHARMACEUTICALS LP], section 2.1)
- Checked Oct 23, 2026
ZincPredictedTaken together, Zinc may cut how much Rosuvastatin is absorbed; spacing them apart is usually discussed.
minor · Predicted from how each works, not established · Absorption in the gut
Predicted from what each is known to do, not studied as a pair and not established.
Taken together, Zinc may cut how much Rosuvastatin is absorbed; spacing them apart is usually discussed.
- NIH Office of Dietary Supplements · Zinc: binds medicines in the gut (Office of Dietary Supplements · Zinc: Fact Sheet for Health Professionals, Interactions with Medications > Antibiotics)
- FDA drug label (DailyMed) · Rosuvastatin: absorption affected by other products (CRESTOR (ROSUVASTATIN) TABLET, FILM COATED [ASTRAZENECA PHARMACEUTICALS LP], section 2.1)
- Checked Oct 23, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Rosuvastatin with everything else you take, together
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