Aspirin (low dose) and supplements: 2 sourced interactions
NSAID, low-dose aspirin, also sold as Bayer, Ecotrin, Bufferin and St. Joseph. Of these, 2 named by an FDA label or NIH page. Plus 3 predicted from how each works (not established). Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Aspirin (low dose) with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
5GarlicLabel or NIHAn NIH page names this pair (platelets and bleeding).
moderate · Named by an FDA label or NIH page · Platelets and bleeding
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“This is especially important if you are going to have surgery or if you take medicines, such as anticoagulants or aspirin, that may also affect bleeding.”
- NIH National Center for Complementary and Integrative Health · Garlic: Usefulness and Safety, What Do We Know About Safety?
- Checked Oct 23, 2026
Vitamin ELabel or NIHAn NIH page names this pair (platelets and bleeding).
moderate · Named by an FDA label or NIH page · Platelets and bleeding
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Because the majority of physicians in the latter study were also taking aspirin, this finding could indicate that vitamin E has a tendency to cause bleeding.”
- NIH Office of Dietary Supplements · Office of Dietary Supplements · Vitamin E, Health Risks from Excessive Vitamin E
- Checked Oct 25, 2026
Asian ginsengPredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- FDA drug label (DailyMed) · Aspirin (low dose): affects clotting or platelets (Bayer Low Dose Aspirin Regimen (aspirin 81 mg delayed-release tablet), OTC Drug Facts, Drug Facts: Warnings · Stomach bleeding warning)
- NIH National Center for Complementary and Integrative Health · Asian ginseng: affects clotting or platelets (Asian Ginseng: Usefulness and Safety, What Do We Know About Safety?)
- Checked Oct 25, 2026
Fish oil (omega-3)PredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- NIH Office of Dietary Supplements · Fish oil (omega-3): affects clotting or platelets (Office of Dietary Supplements · Omega-3 Fatty Acids: Fact Sheet for Health Professionals, Interactions with Medications > Warfarin (Coumadin) and similar anticoagulants)
- FDA drug label (DailyMed) · Aspirin (low dose): affects clotting or platelets (Bayer Low Dose Aspirin Regimen (aspirin 81 mg delayed-release tablet), OTC Drug Facts, Drug Facts: Warnings · Stomach bleeding warning)
- Checked Oct 23, 2026
Ginkgo bilobaPredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- NIH National Center for Complementary and Integrative Health · Ginkgo biloba: affects clotting or platelets (Ginkgo: Usefulness and Safety, What Do We Know About Safety?)
- FDA drug label (DailyMed) · Aspirin (low dose): affects clotting or platelets (Bayer Low Dose Aspirin Regimen (aspirin 81 mg delayed-release tablet), OTC Drug Facts, Drug Facts: Warnings · Stomach bleeding warning)
- Checked Oct 23, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Aspirin (low dose) with everything else you take, together
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- Interaction MapCheck several medicines and supplements at once, each interaction sourced to PubMed, FDA labels or NIH; a pair we have no source for reads as not on our list, never as safe.