Bupropion and supplements: 2 sourced interactions
Antidepressant (NDRI), also sold as Wellbutrin XL, Wellbutrin SR, Aplenzin and Zyban. Of these, 2 named by an FDA label or NIH page. Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Bupropion with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
2SAMeLabel or NIHAn NIH page names this pair (serotonin activity).
moderate · Named by an FDA label or NIH page · Serotonin activity
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“It’s also possible that SAMe might interact with drugs and dietary supplements that increase levels of serotonin (a chemical produced by nerve cells), such as antidepressants, L-tryptophan, and St. John’s wort.”
- NIH National Center for Complementary and Integrative Health · S-Adenosyl-L-Methionine (SAMe): In Depth, Safety and Side Effects of SAMe
- Checked Oct 25, 2026
St John's wortLabel or NIHAn NIH page names this pair (cause not established).
moderate · Named by an FDA label or NIH page · Cause not established
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“For example, St. John’s wort can weaken the effects of many medicines, including crucially important medicines”
- NIH National Center for Complementary and Integrative Health · St. John’s Wort: Usefulness and Safety, What Do We Know About Safety?
- Checked Oct 23, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Bupropion with everything else you take, together
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- St. John's wortSt.
- Interaction MapCheck several medicines and supplements at once, each interaction sourced to PubMed, FDA labels or NIH; a pair we have no source for reads as not on our list, never as safe.