Simvastatin and supplements: 2 sourced interactions
Statin, also sold as Zocor. Of these, 2 named by an FDA label or NIH page. Plus 1 food and drink line. Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Simvastatin with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
2St John's wortLabel or NIHAn NIH page names this pair (cause not established).
moderate · Named by an FDA label or NIH page · Cause not established
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“For example, St. John’s wort can weaken the effects of many medicines, including crucially important medicines”
- NIH National Center for Complementary and Integrative Health · St. John’s Wort: Usefulness and Safety, What Do We Know About Safety?
- Checked Oct 23, 2026
Vitamin ELabel or NIHAn NIH page names this pair (platelets and bleeding).
moderate · Named by an FDA label or NIH page · Platelets and bleeding
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Vitamin E supplements can interact with certain medications, including anticoagulants, antiplatelets, simvastatin, and niacin.”
“This collection of antioxidant ingredients blunted the rise in high-density lipoprotein (HDL) cholesterol levels among people who were treated with a combination of simvastatin (brand name Zocor) and niacin [64,65].”
- NIH Office of Dietary Supplements · Office of Dietary Supplements · Vitamin E, Interactions with Medications · Simvastatin and niacin
- Checked Oct 25, 2026
Simvastatin with food and drink
Food and drink
1GrapefruitLabel or NIHThe FDA label names this pair (breakdown by liver enzymes).
moderate · Named by an FDA label or NIH page · Breakdown by liver enzymes
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Lipid modifying doses (≥1 gram/day) of niacin, fibrates, colchicine, and grapefruit juice may also increase the risk of myopathy and rhabdomyolysis”
“Grapefruit juice can raise the plasma levels of simvastatin and may increase the risk of myopathy and rhabdomyolysis.”
“Avoid grapefruit juice when taking ZOCOR.”
“Lipid modifying doses (≥1 gram/day) of niacin, fibrates, colchicine, and grapefruit juice may also increase the risk of myopathy and rhabdomyolysis [see Drug Interactions (7.1)].”
- FDA drug label (DailyMed) · ZOCOR (SIMVASTATIN) TABLET, FILM COATED [ORGANON LLC], section 5.1
- Checked Oct 23, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Simvastatin with everything else you take, together
Keep reading: Supplements and vitamins
Supplements and vitamins: every pageSupplement & Nutrient EncyclopediaBrowse all topics
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- Interaction MapCheck several medicines and supplements at once, each interaction sourced to PubMed, FDA labels or NIH; a pair we have no source for reads as not on our list, never as safe.
- St. John's wortSt.