Anti-Aging

Humanin-HNG

S14G-humanin · HNG · Gly14-humanin

S14G substitution on humanin (HNG) - a more potent analog of the mitochondrial 24-aa peptide we already list. Used in cell and animal neuroprotection papers. Potency in a dish is not a human dose table. Not FDA-approved.

Not FDA-approved - research chemical

Quick answer

What it is: S14G substitution on humanin (HNG) - a more potent analog of the mitochondrial 24-aa peptide we already list.

Typical research dose: Research; parent humanin community range 1-5 mg is not an HNG label

Reconstitution calculator ↓NAD+ injections online: providers and cost →Telehealth clinics that prescribe peptides →

Research summary, not medical advice.

Reviewed by Kymata Health Editorial Team

·Last updated: August 2026·Evidence: Low

Typical research dose

Research; parent humanin community range 1-5 mg is not an HNG label

Frequency

1× daily (research)

Half-life

Short (parent ~30 min)

Common vials

5 mg

CAS

N/A

Molecular weight

~2.7 kDa class (24-aa analog)

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

Longevity / aging2.5/10
More potent analog in cell/animal work. Still not a human indication.

Compound card

Class: S14G-humanin analog (HNG)
Formula: S14G-humanin
Status: Not FDA-approved · research use

Dose it

5 mg + 2 mL BAC water → 2.5 mg/mL · 500 mcg ≈ 20 units (U-100)

Open in calculator

How it works

HNG is humanin with serine-14 replaced by glycine. In published models that substitution increases potency versus native humanin. Parent humanin is a 24-aa mitochondrial ORF peptide (PMID 11371646).

Potency in a dish is not a milligram conversion table. Do not treat HNG as “humanin but you use less” unless a paper says so for that exact endpoint.

Source: Humanin PMID: 11371646; HNG analog literature (S14G)

Research Use Cases

✓MDP analog identity: Low

Dosing

Phase	Dose	Frequency	Notes
Human	None established	n/a	Parent community mg ranges are already unlabeled. HNG is not automatically a lower milligram.

Administration

Route / form

SC research (vendor)

Timing

Not established.

Empty stomach?

No - Food timing is not critical.

Timeline

Models

Neuroprotection papers - not a consumer timeline.

Who it is for

MDP analog identity

Low

We list native humanin separately. This is the S14G SKU.

Reconstitution

Vial	Water	Concentration	Example dose
5 mg lyophilized	2 mL BAC	2.5 mg/mL	Analog math. Confirm the COA says HNG, not humanin.

Change vial size or water volume? Open the reconstitution calculator.

Safety & Considerations

Research analog. Mitochondrial peptides are not gentle longevity vitamins. No approved indication.

Regulatory & Legal Status

FDA Status (US)

Research Only

S14G humanin analog. Not an approved MDP drug

WADA Status (2026)

Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

Do not transfer humanin community mcg onto HNG 1:1.

Verdict

HNG is S14G-humanin. Potency in assays is not a human dose table. Not parent humanin.

Interactions & Contraindications

Research analog. Mitochondrial peptides are not gentle longevity vitamins. No approved indication.

Humanin-HNG vs. Humanin

Canonical comparison: Humanin-HNG vs Humanin

Attribute	Humanin-HNG	Humanin
Sequence	S14G substitution (HNG)	Native 24-aa MDP
Potency (models)	Higher in published cell/animal work	Parent MDP
Human dose	Not established	Not established (community mg ranges exist)

Verdict: HNG is a point mutant, not a new gene. Do not copy humanin milligram folklore onto HNG without a citation.

Frequently Asked Questions

Is HNG just stronger humanin?▼

In some models, S14G is more potent. That is not a human dose chart and not a longer half-life by default.

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