Cosmetic Peptide

SYN-AKE

Tripeptide-3 · Dipeptide diaminobutyroyl benzylamide diacetate · Waglerin-1 analog

Waglerin-1-inspired tripeptide (DSM/Pentapharm SYN-AKE) for expression lines. Topical cosmetic next to Argireline/SNAP-8/Leuphasyl. Not snake venom, not a neuromuscular drug, not injectable Botox.

Not FDA-approved - research chemical

Quick answer

What it is: Waglerin-1-inspired tripeptide (DSM/Pentapharm SYN-AKE) for expression lines.

Typical research dose: Topical 1–4% solutions (INCI cosmetic use)

Dosing details ↓

Research summary, not medical advice.

Reviewed by Kymata Health Editorial Team

·Last updated: August 2026·Evidence: Low

Typical research dose

Topical 1–4% solutions (INCI cosmetic use)

Frequency

1-2× daily topical

Half-life

Topical cosmetic

Common vials

N/A (oral)

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

Skin / cosmetic3/10
Snake-venom-mimetic marketing. Cosmetic nicotinic-receptor story, not Botox.

Compound card

Class: Waglerin-1 analog tripeptide (topical cosmetic)
Formula: Dipeptide diaminobutyroyl benzylamide diacetate (tripeptide-3 class)
Status: Not FDA-approved · research use

How it works

SYN-AKE is a waglerin-1-inspired tripeptide (DSM/Pentapharm) used in topical expression-line formulas. The claimed mechanism is nicotinic-receptor antagonism in a cosmetic model. It is not snake venom, not botulinum toxin, and not Argireline’s SNARE decoy.

Source: Pentapharm / DSM SYN-AKE technical literature

Research Use Cases

✓Cosmetic catalog completeness: Low

Dosing

Phase	Dose	Frequency	Notes
Topical cosmetic	1–4% in finished formulas (typical)	1–2× daily	Not injectable.

Administration

Route / form

Topical only on this page

Timing

AM/PM skincare.

Empty stomach?

No - Food timing is not critical.

Timeline

Weeks (cosmetic)

Expression-line marketing.

Who it is for

Cosmetic catalog completeness

Low

Shelf-mate of Argireline, SNAP-8, Leuphasyl.

Safety & Considerations

Cosmetic ingredient. Not venom. Not a neuromuscular drug. Patch-test finished formulas.

Regulatory & Legal Status

FDA Status (US)

Research Only

Cosmetic waglerin analog (tripeptide-3). Not a neuromuscular drug

WADA Status (2026)

Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

INCI cosmetic.

Verdict

SYN-AKE is a topical waglerin analog. Not venom and not an injectable neuromuscular drug.

Interactions & Contraindications

Cosmetic ingredient. Not venom. Not a neuromuscular drug. Patch-test finished formulas.

SYN-AKE vs. Argireline

Canonical comparison: SYN-AKE vs Argireline

Attribute	SYN-AKE	Argireline
Inspiration	Waglerin-1 (nAChR cosmetic analog)	SNAP-25 SNARE decoy
INCI	Tripeptide-3 / dipeptide diaminobutyroyl benzylamide diacetate	Acetyl hexapeptide-8
Use	Topical expression lines	Topical expression lines

Verdict: SYN-AKE is not Argireline and not venom. Cosmetic peptides, topical only on this site.

Frequently Asked Questions

Is SYN-AKE snake venom?▼

No. It is a synthetic analog inspired by waglerin-1, used topically in cosmetics.

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