Cosmetic Peptide

Leuphasyl

Pentapeptide-18 · Tyr-D-Ala-Gly-Phe-Leu

Pentapeptide-18, an enkephalin-related expression-line peptide sold next to Argireline and SNAP-8. Topical cosmetic, not a reconstitution job. We list it so the library matches the catalog people actually search.

Not FDA-approved - research chemical

Quick answer

What it is: Pentapeptide-18, an enkephalin-related expression-line peptide sold next to Argireline and SNAP-8.

Typical research dose: Topical 3–10% solutions (INCI cosmetic use)

Dosing details ↓

Research summary, not medical advice.

Reviewed by Kymata Health Editorial Team

·Last updated: August 2026·Evidence: Low

Typical research dose

Topical 3–10% solutions (INCI cosmetic use)

Frequency

1-2× daily topical

Half-life

Topical cosmetic

Common vials

N/A (oral)

CAS

N/A (cosmetic ingredient)

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

Skin / cosmetic3/10
Expression-line cosmetic. Different mechanism from Argireline.

Compound card

Class: Pentapeptide-18 (topical enkephalin-like cosmetic)
Formula: Pentapeptide-18
Status: Not FDA-approved · research use

How it works

Leuphasyl is INCI pentapeptide-18, an enkephalin-related expression-line peptide. It sits on the same cosmetic shelf as Argireline (SNAP-25 decoy) and SYN-AKE (waglerin analog). Different sequence, same job-to-be-done: topical expression lines.

No reconstitution calculator - typicalDose is topical percent, not mcg in a syringe.

Source: INCI pentapeptide-18 / Lipotec cosmetic literature (not a drug label)

Research Use Cases

✓Cosmetic catalog completeness: Low

Dosing

Phase	Dose	Frequency	Notes
Topical cosmetic	3–10% in finished formulas (typical INCI use)	1–2× daily	Not injectable.

Administration

Route / form

Topical only on this page

Timing

AM/PM skincare.

Empty stomach?

No - Food timing is not critical.

Timeline

Weeks (cosmetic)

Expression-line marketing. Not botulinum toxin.

Who it is for

Cosmetic catalog completeness

Low

Listed next to Argireline/SNAP-8 so search matches the shelf.

Safety & Considerations

Cosmetic ingredient. Not injectable. Not a drug. Patch-test finished formulas.

Regulatory & Legal Status

FDA Status (US)

Research Only

Cosmetic pentapeptide-18. Not a drug

WADA Status (2026)

Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

INCI literature, not a drug label.

Verdict

Leuphasyl is pentapeptide-18. Topical. Not an opioid. Not a reconstitution job.

Interactions & Contraindications

Cosmetic ingredient. Not injectable. Not a drug. Patch-test finished formulas.

Leuphasyl vs. Argireline

Canonical comparison: Leuphasyl vs Argireline

Attribute	Leuphasyl	Argireline
INCI	Pentapeptide-18	Acetyl hexapeptide-8
Claimed mechanism	Enkephalin-like expression-line peptide	SNAP-25 / SNARE decoy
Calculator	Topical - no recon math	Topical - no recon math

Verdict: Same shelf, different sequences. Neither is injectable botulinum toxin.

Frequently Asked Questions

Can I inject Leuphasyl?▼

This leaf is topical cosmetic. Do not treat INCI percents as syringe mcg.

Prescription options: compare licensed telehealth providers

Some peptide therapies are available only by prescription after a consult with a licensed clinician.

Compare telehealth →

← Back to Peptide Library