Spironolactone and supplements: 2 sourced interactions
Potassium-sparing diuretic, also sold as Aldactone and CaroSpir. Of these, 2 named by an FDA label or NIH page. Plus 1 predicted from how each works (not established). Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Spironolactone with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
2AshwagandhaLabel or NIHAn NIH page names this pair (cause not established).
moderate · Named by an FDA label or NIH page · Cause not established
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“There is evidence that ashwagandha might interact with some medications, including those for diabetes and high blood pressure, medicines that decrease the immune system response (immunosuppressants), sedatives, anti-seizure medications (anticonvulsants), and thyroid hormone medications.”
- NIH National Center for Complementary and Integrative Health · Ashwagandha: Usefulness and Safety, What Do We Know About Safety?
- Checked Oct 23, 2026
Potassium (supplements / salt substitutes)Label or NIHThe FDA label names this pair (potassium level).
moderate · Named by an FDA label or NIH page · Potassium level
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“This risk is increased by impaired renal function or concomitant potassium supplementation, potassium-containing salt substitutes or drugs that increase potassium, such as angiotensin converting enzyme inhibitors and angiotensin receptor blockers [see Drug Interactions (7.1)].”
“Concomitant administration of ALDACTONE with potassium supplementation or drugs that can increase potassium may lead to severe hyperkalemia.”
“Concomitant administration of ALDACTONE with potassium supplementation, salt substitutes containing potassium, a diet rich in potassium, or drugs that can increase potassium, including ACE inhibitors, angiotensin II antagonists, non-steroidal anti-inflammatory drugs (NSAIDs), heparin and low molecular weight heparin, may lead to severe hyperkalemia [see Warnings and Precautions (5.1)and Drug Interactions (7.1)].”
“However, in people with impaired urinary potassium excretion due to chronic kidney disease or the use of certain medications, such as angiotensin converting enzyme (ACE) inhibitors or potassium-sparing diuretics, even dietary potassium intakes below the AI can cause hyperkalemia [11].”
“Potassium-sparing diuretics, such as amiloride (Midamor) and spironolactone (Aldactone), reduce the excretion of potassium in the urine and can cause hyperkalemia [77,78].”
- FDA drug label (DailyMed) · ALDACTONE (SPIRONOLACTONE) TABLET, FILM COATED [PFIZER LABORATORIES DIV PFIZER INC], section 12.3
- NIH Office of Dietary Supplements · Office of Dietary Supplements · Potassium, Interactions with Medications · Potassium-sparing diuretics
- Checked Oct 25, 2026
Minor
1Red yeast ricePredictedBoth lower blood pressure, which may add up.
minor · Predicted from how each works, not established · Blood pressure lowering
Predicted from what each is known to do, not studied as a pair and not established.
Both lower blood pressure, which may add up.
- FDA drug label (DailyMed) · Spironolactone: lowers blood pressure (ALDACTONE (SPIRONOLACTONE) TABLET, FILM COATED [PFIZER LABORATORIES DIV PFIZER INC], section 1.2)
- NIH National Center for Complementary and Integrative Health · Red yeast rice: lowers blood pressure (Red Yeast Rice: What You Need To Know, Are red yeast rice products effective?)
- Checked Oct 25, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Spironolactone with everything else you take, together
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