Khavinson BioregulatorTarget: ThymusImmune

Crystagen

Glu-Asp-Pro · EDP · Immune Bioregulator Tripeptide · Кристаген

Crystagen is the synthetic immune cytogen Glu-Asp-Pro (EDP) on the NPCRIZ list - thymus/immunocompetent cells. It is not a colon peptide. English catalogs that print “gut” or Lys-Glu-Asp for Crystagen mixed it up with Vesugen (KED) or with a GI extract.

Not FDA-approved - research chemical

Quick answer

What it is: Crystagen is the synthetic immune cytogen Glu-Asp-Pro (EDP) on the NPCRIZ list - thymus/immunocompetent cells.

Class and target: Cytogen (synthetic short peptide) · Thymus / immunocompetent cells (not colon) · sequence EDP

Typical research dose: 1–2 capsules/day (Cytomed) or 1–2 mg SC (research vial)

Reconstitution calculator ↓What it is & the evidence on The Bioregulator Atlas →

Research summary, not medical advice.

Reviewed by Kymata Health Editorial Team
Last updated: August 2026Evidence: Low3 peer-reviewed citations
Typical research dose
1–2 capsules/day (Cytomed) or 1–2 mg SC (research vial)
Frequency
1× daily for 10-30 day cycles
Half-life
Short (tripeptide)
Common vials
5 mg / 10 mg
CAS
N/A
Molecular weight
Tripeptide class (confirm COA)

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

  • Longevity / aging3.5/10

    Khavinson-school tissue peptide. Single-lab concentration after haircut. Not a Western Phase 3 geroprotector.

  • Immune3.5/10

    Thymus/immune organ map in the school. Not Zadaxin and not a US immune-deficiency drug.

Compound card

Sequence
EDP
Class
Khavinson cytogen (EDP)
Formula
Glu-Asp-Pro (EDP tripeptide)
Status
Not FDA-approved · research use
Dose it
5 mg + 2.5 mL BAC water → 2 mg/mL · 1000 mcg ≈ 50 units (U-100)
Open in calculator

How it works

Crystagen is the synthetic immune cytogen Glu-Asp-Pro (EDP) on the NPCRIZ list - thymus and immunocompetent cells. It is not a colon peptide and it is not Lys-Glu-Asp (that sequence is Vesugen, KED, vessels).

Vilon (KE) is the thymus-specific dipeptide with the chromatin papers. Thymogen (EW) is the other immune dipeptide. Vladonix is the thymus Cytomax complex. Crystagen is the broader immune-cell motif in the school’s own telling. English catalogs that print “gut” mixed this ID with a GI extract or with KED.

Source: PMID: 15105581

Khavinson map

Canonical 41
Class
Cytogen (synthetic short peptide)
Organ
Thymus / immunocompetent cells (not colon)
Target
Thymus
System
Immune
Sequence
EDP · Glu-Asp-Pro
Pair
Vladonix (thymus Cytomax); neighbors Vilon (KE) and Thymogen (EW)
Кристаген

Used in bioregulator stacks

Manufacturer-style organ combinations - not FDA protocols. Every name is a live leaf.

The Khavinson school

Crystagen is filed here as cytogen (synthetic short peptide), targeting the thymus / immunocompetent cells (not colon). Khavinson's St. Petersburg group moved from organ extracts (Cytamins) to capsule complexes (Cytomaxes) to synthetic short peptides (Cytogens); most of the evidence comes from that one group, with little independent Western replication.

Read the full background, the proposed epigenetic mechanism, the literature limits, and how we count the canonical 41 on the Khavinson bioregulators index.

History of this molecule

Crystagen is one of the 12 cytogens Cytomed actually puts on the poster, labeled thymus/immune. Vilon (KE) is the older, more-cited thymic dipeptide. Thymogen (EW) is the other immune dipeptide with a Russian drug history. Crystagen is the EDP tripeptide aimed at a broader immunocompetent-cell set - marrow, spleen, circulating lymphocytes - while Vilon is the thymus-specific motif in the school’s own telling.

The colon error on our old details page was a real bug: someone assigned Lys-Glu-Asp and “colonic mucosa” to this ID. KED is Vesugen (vessels). Colon/GI is Stamakort’s aisle. We are not going to keep a wrong organ because a spreadsheet said so.

Sequence disputes exist in the wild (EDP vs TEG vs KED). We follow the NPCRIZ immune listing plus our database alias Glu-Asp-Pro, and we flag the dispute instead of pretending every vendor COA agrees.

English-language teachers (including public PSI writing) treat Crystagen as immune restoration, often stacked with Vilon. That pairing is in-school. Stacking Crystagen for “gut healing” is the bug reproducing itself.

Caveats

A defined sequence is not an FDA indication. Immune cytogens sit in a Russian experimental-gerontology literature with limited Western replication. “Oral bioavailability because PEPT1” is real peptide-transport biology; it is not proof this SKU treats the organ disease. Gray-market identity is a live problem - HPLC is the only way to know the vial is the sequence on the label. Autoimmune disease is a caution, not a target. This is not thymosin alpha-1 (Zadaxin).

Full 41-map: Khavinson bioregulators index · Bioregulator stacks

Research Use Cases

  • ✓EDP identity vs Vilon vs Vladonix
  • ✓Not a chronic-infection or NK-cell restoration protocol

Dosing

PhaseDoseFrequencyNotes
Khavinson Protocol1–2 capsules/day or 1–2 mg SCDaily for 10–30 day courses, 1–2× per yearImmune cytogen. Not a GI course. Repeat 1-2x per year in the school’s cycling logic.

Administration

Route / form
Two real SKUs: Cytomed oral capsules (swallowed) or a lyophilized research vial reconstituted for subcutaneous injection. Nobody manufactures these as sublingual tablets.
Timing
Capsules: morning, about 30 minutes before meals. Research vial (SubQ): food does not change the injection.
Empty stomach?
Capsules: yes - Swallow on an empty stomach, about 30 minutes before meals. Reconstituted vial (SubQ): food does not change the injection. Cytomed boxes sometimes print “with food” because they are labeled as supplements; the manufacturer user-guide preference is before meals.

Crystagen: oral vs SubQ

Cytomed oral capsule
Bioavailability
No published human F% for this SKU. Di- and tripeptides can ride PEPT1/LAT; that is transporter biology, not proof the capsule treats the named organ. Cytomed cytogen capsules are swallowed.
Dose note
Crystagen Cytomed cytogen capsules: 1–2 capsules/day, typically 10–30 day courses. No reconstitution. Swallow; do not melt under the tongue. Swallowed with water. Morning, about 30 minutes before meals, is manufacturer user-guide folklore. Cytomed boxes sometimes print “with food” because they are labeled as supplements. That is not a published absorption RCT for this SKU. Pair: Vladonix is the thymus Cytomax. Neighbors Vilon (KE) and Thymogen (EW) are different immune cytogens. Thymalin is the extract.
Advantages
  • Official Cytomed cytogen SKU is a swallowed capsule. No BAC water, no syringe.
  • Matches how Cytomed ships the poster line.
  • Nobody manufactures this as a sublingual tablet.
  • Oral EDP is a tripeptide, so the PEPT1 conversation is at least biologically plausible, still not an immune indication.
Considerations
  • Capsule milligrams are not 1–2 mg SC. Do not convert a research-vial protocol into capsule counts by arithmetic theater.
  • Empty-stomach timing is user-guide folklore plus PEPT1 logic, not a cited human PK study for this SKU.
  • Crystagen is EDP for thymus / immunocompetent cells. It is not a colon peptide. KED is Vesugen (vessels). English catalogs that print “gut” or Lys-Glu-Asp on this ID mixed the bottles.
  • Do not swallow this as IBD or “gut healing.” That organ bug is how wrong capsules get bought.
Research vial SubQ
Bioavailability
No published human PK curve for this cytogen. Research-chem SubQ is the gray-market route. Class estimate is minutes-to-hours, not a depot ester.
Dose note
Research lyophilized vial: reconstitute with bacteriostatic water, sterile technique, SubQ. Class pattern is about 1–2 mg daily for on the order of 10 days, not a 12-week GLP-1 titration. Food does not change the injection. Do not convert Cytomed capsule counts into vial milligrams. Pair: Vladonix is the thymus Cytomax. Neighbors Vilon (KE) and Thymogen (EW) are different immune cytogens. Thymalin is the extract.
Advantages
  • Vial math is checkable if the COA matches the sequence on the label.
  • Food timing is irrelevant for SubQ.
  • Short pulsed courses match how the school used defined synthetics.
Considerations
  • Gray-market identity: HPLC is the only way to know the cake is EDP (Glu-Asp-Pro).
  • Not a Western Phase 3. Russian experimental-gerontology literature is real and concentrated.
  • Not a sublingual tablet and not a Cytomax complex.
  • Crystagen is EDP for thymus / immunocompetent cells. It is not a colon peptide. KED is Vesugen (vessels). English catalogs that print “gut” or Lys-Glu-Asp on this ID mixed the bottles.
  • This is not thymosin alpha-1 (Zadaxin). Autoimmune disease is a caution, not a target.
Recommendation: Two SKUs. Swallow Cytomed Crystagen capsules (no recon, not sublingual) or BAC-reconstitute a research vial for SubQ at the 1–2 mg / ~10-day class pattern. Food does not change the shot. Pair: Vladonix is the thymus Cytomax. Neighbors Vilon (KE) and Thymogen (EW) are different immune cytogens. Thymalin is the extract. Crystagen is EDP for thymus / immunocompetent cells. It is not a colon peptide. KED is Vesugen (vessels). English catalogs that print “gut” or Lys-Glu-Asp on this ID mixed the bottles. Russian literature is real; Western Phase 3 is not. If the label says colon or KED, it is the wrong peptide.

Timeline

Day 1-10 (course)
Immune-cell gene-expression signaling in the Khavinson map - not intestinal motility.
Month 3-6
Cycling logic is gerontology practice, not an IBD reinduction protocol.

Who it is for

Immune / thymic (research)

Low

EDP immune cytogen. Not colon. Not Vesugen. Autoimmune disease is a caution, not a target.

Reconstitution

VialWaterConcentrationExample dose
Lyophilized cytogen (if the SKU is a vial)Follow the COA fillDo the mathCapsules skip this step. Cytomax complexes are not this molecule.

Change vial size or water volume? Open the reconstitution calculator.

Safety & Considerations

Research peptide. Russian clinical-protocol history is not an FDA indication. Not thymosin alpha-1. Sequence disputes exist - demand HPLC.

Regulatory & Legal Status

FDA Status (US)
Research Only
WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

  • A defined sequence is not an FDA indication.
  • Gray-market identity is a live problem. HPLC beats a blog table.
  • Do not paste a sibling cytogen’s papers onto this SKU.
  • This site will not treat the named organ disease from a peptide page.

Verdict

Crystagen is the synthetic EDP cytogen for Thymus / immunocompetent cells (not colon). Khavinson’s group published in this family. That is a concentrated literature, not a Western Phase 3. Capsules and vials are different SKUs.

Interactions & Contraindications

Autoimmune disease is a caution, not a target.

Synergies & Common Stacks

+ Vilon →

Two immune-aisle cytogens (EDP vs KE). Not a layered restoration regimen.

Frequently Asked Questions

Does Crystagen target the colon?▼
No. Official NPCRIZ organ is thymus/immune. Colon listings are catalog errors. KED is Vesugen (vessels), not Crystagen.
Oral capsule or injection?▼
Two SKUs. Cytomed Crystagen is a swallowed cytogen capsule (1–2/day, typical 10–30 day courses, morning empty-stomach folklore, no reconstitution, not a sublingual tablet). Research vials are BAC-reconstituted SubQ at about 1–2 mg for on the order of 10 days; food does not change the shot. EDP immune, not colon, not Vesugen (KED). Vladonix is the thymus Cytomax.
Crystagen vs Vilon vs Thymogen vs Vladonix?▼
Crystagen = EDP immune cytogen. Vilon = KE thymus dipeptide. Thymogen = EW dipeptide. Vladonix = thymus Cytomax complex.
Sequence?▼
We list Glu-Asp-Pro (EDP). Some vendors disagree. Ask for HPLC, not a blog table.
TA-1?▼
Different molecule, different developer, different regulatory story.
What does Crystagen do for the gut?▼
It does not. That FAQ was a bug. Crystagen is an immune/thymus cytogen (EDP). GI mucosa is Stamakort’s aisle. KED is Vesugen (vessels).

References

  1. Khavinson VKh et al. “Tissue-specific effects of peptides.” Bulletin of Experimental Biology and Medicine (2001). PMID: 11713572
  2. Khavinson VKh, Lin’kova NS, Tarnovskaya SI “Short peptides regulate gene expression.” Bulletin of Experimental Biology and Medicine (2016). PMID: 27909961
  3. Khavinson VKh, Morozov VG “Peptides of pineal gland and thymus prolong human life.” Neuroendocrinology Letters (2003). PMID: 14523363

📚 Related Articles

Khavinson Bioregulators: Vilon, Thymalin, Cortexin & the Russian Peptide Legacy
14 min read • Longevity
Where to get itOral bioregulator

Affiliate links: we earn a commission if you buy, at no extra cost to you.

Thymusol is Vita-Stream's US-made thymus bioregulator (Vita Peptides' own house line), a different product from Crystagen. No trial has tested it.

Browse Thymusol

Get Crystagen from Vita-Stream, which sells the GARMONIA Cytomax and Cytogen oral capsules. No reconstitution math on a capsule bottle.

Browse Crystagen

Use code KymataLabs at checkout

See all sources and our full review

← Back to Peptide Library·Bioregulator stacks