Khavinson BioregulatorTarget: LiverDigestive

Livagen

Lys-Glu-Asp-Ala · KEDA · Liver & DNA Bioregulator · Ливаген

Livagen is synthetic Lys-Glu-Asp-Ala (KEDA), the liver tetrapeptide used in chromatin-decondensation demonstrations. Svetinorm is the liver Cytomax. Ovagen is the other liver cytogen (not ovary).

Not FDA-approved - research chemical

Quick answer

What it is: Livagen is synthetic Lys-Glu-Asp-Ala (KEDA), the liver tetrapeptide used in chromatin-decondensation demonstrations.

Class and target: Cytogen (synthetic short peptide) · Liver · sequence KEDA

Typical research dose: 1–2 capsules/day (Cytomed) or 1–2 mg SC (research vial)

Reconstitution calculator ↓What it is & the evidence on The Bioregulator Atlas →

Research summary, not medical advice.

Reviewed by Kymata Health Editorial Team
Last updated: August 2026Evidence: Low3 peer-reviewed citations
Typical research dose
1–2 capsules/day (Cytomed) or 1–2 mg SC (research vial)
Frequency
1× daily for 10-30 day cycles
Half-life
Short (tetrapeptide)
Common vials
5 mg / 10 mg
CAS
N/A
Molecular weight
476.48 g/mol

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

  • Longevity / aging3.5/10

    Khavinson-school tissue peptide. Single-lab concentration after haircut. Not a Western Phase 3 geroprotector.

  • Metabolic / weight3/10

    GI/metabolic organ map. Not a GLP-1 and not a diabetes drug.

Compound card

Sequence
KEDA
Class
Khavinson cytogen (KEDA)
Formula
C18H32N6O9
Status
Not FDA-approved · research use
Dose it
5 mg + 2.5 mL BAC water → 2 mg/mL · 1000 mcg ≈ 50 units (U-100)
Open in calculator

How it works

Livagen (Lys-Glu-Asp-Ala) is a tetrapeptide bioregulator targeting hepatocyte (liver cell) gene expression and chromatin structure. It restores liver metabolic enzyme production, detoxification gene expression, and hepatocellular regeneration capacity in aged cells. Khavinson demonstrated chromatin relaxation in hepatocytes treated with Livagen, restoring transcription of liver-specific proteins suppressed by aging.

Khavinson map

Canonical 41
Class
Cytogen (synthetic short peptide)
Organ
Liver
Target
Liver
System
Digestive
Sequence
KEDA · Lys-Glu-Asp-Ala
Pair
Svetinorm (liver Cytomax); Ovagen (EDL) is the other liver cytogen
Ливаген

Used in bioregulator stacks

Manufacturer-style organ combinations - not FDA protocols. Every name is a live leaf.

The Khavinson school

Livagen is filed here as cytogen (synthetic short peptide), targeting the liver. Khavinson's St. Petersburg group moved from organ extracts (Cytamins) to capsule complexes (Cytomaxes) to synthetic short peptides (Cytogens); most of the evidence comes from that one group, with little independent Western replication.

Read the full background, the proposed epigenetic mechanism, the literature limits, and how we count the canonical 41 on the Khavinson bioregulators index.

History of this molecule

If you only remember one “epigenetic peptide” story besides Epitalon, it is Livagen unwinding heterochromatin in old hepatocytes and lymphocytes so ribosomal genes can be read again. That is the Khavinson demo. It is also why English teachers love this molecule.

It is not a hepatitis C cure. It is not a NASH outcomes drug. Svetinorm is the complex. Ovagen is EDL on the official poster.

Caveats

A defined sequence is not an FDA indication. Liver cytogens sit in a Russian experimental-gerontology literature with limited Western replication. “Oral bioavailability because PEPT1” is real peptide-transport biology; it is not proof this SKU treats the organ disease. Gray-market identity is a live problem - HPLC is the only way to know the vial is the sequence on the label.

Full 41-map: Khavinson bioregulators index · Bioregulator stacks

Research Use Cases

  • ✓KEDA identity vs Svetinorm vs Ovagen
  • ✓Not a liver-regeneration or detox protocol

Dosing

PhaseDoseFrequencyNotes
Khavinson Protocol1–2 capsules/day or 1–2 mg SCDaily for 10–30 day courses, 1-2x per yearLiver bioregulator course. Particularly valuable after hepatotoxic exposure or age-related liver decline. Repeat 1-2x per year.

Administration

Route / form
Two real SKUs: Cytomed oral capsules (swallowed) or a lyophilized research vial reconstituted for subcutaneous injection. Nobody manufactures these as sublingual tablets.
Timing
Capsules: morning, about 30 minutes before meals. Research vial (SubQ): food does not change the injection.
Empty stomach?
Capsules: yes - Swallow on an empty stomach, about 30 minutes before meals. Reconstituted vial (SubQ): food does not change the injection. Cytomed boxes sometimes print “with food” because they are labeled as supplements; the manufacturer user-guide preference is before meals.

Livagen: oral vs SubQ

Cytomed KEDA capsule
Bioavailability
Cytomed oral KEDA capsules, swallowed with water. Cytomed still ships an oral cytogen capsule. Tetrapeptides are a weaker PEPT1 story than KE/EW dipeptides. Swallow if that is the SKU you bought; do not invent a sublingual melt.
Dose note
Cytomed folklore: 1–2 capsules daily, 10–30 day courses, morning, about 30 minutes before meals. Manufacturer protocol, not an FDA label.
Advantages
  • Official cytogen capsule SKU. No reconstitution.
  • Same sequence claim as the vial if the box is Livagen.
  • Not a sublingual tablet. Nobody manufactures this SKU that way.
Considerations
  • Svetinorm is the liver Cytomax mixture. Different class, different dose sheet.
  • Ovagen is the other liver cytogen (EDL, not ovary). Do not swap bottles by name vibe.
  • Empty-stomach timing is a user-guide preference, not a PK study.
Research KEDA vial
Bioavailability
Research SubQ from a reconstituted KEDA (Lys-Glu-Asp-Ala) vial. Liver tetrapeptide. Not Svetinorm capsules and not a hepatology infusion.
Dose note
Research-vial pattern: short course on the order of 10 days at 1–2 mg subcutaneous. Not a 12-week GLP-1 titration. Capsules skip BAC math. Do not copy Epitalon’s 5–10 mg/day folklore onto KEDA.
Advantages
  • Defined tetrapeptide. Vial math belongs on powder, not on Svetinorm.
  • Separable from Ovagen (EDL, also liver) and from the liver Cytomax complex.
  • SubQ skips GI for a tetrapeptide whose oral PEPT1 story is already thin.
Considerations
  • Not a NASH outcomes drug. Chromatin demos are not a billed epigenetic procedure.
  • Two liver cytogens exist (KEDA vs EDL). Confirm the COA.
  • Sterile technique. Cloudy vial: discard.
Recommendation: Livagen (KEDA) is capsule-or-vial: Cytomed oral course and research SubQ. It is not Svetinorm (liver Cytomax), not Ovagen (EDL), and not a sublingual tablet. If you bought capsules, skip the calculator. If you bought powder, 1–2 mg SC short courses - not an Epitalon 5–10 mg chart.

Timeline

Day 1-10 (course)
Hepatocyte chromatin relaxation. Restoration of liver gene transcription.
Month 3-6
Improved liver enzyme markers and detoxification capacity with repeat courses.

Who it is for

Hepatic Aging / Liver Health

Low

Liver-specific bioregulator. Restores hepatocyte gene expression suppressed by aging.

Reconstitution

VialWaterConcentrationExample dose
Lyophilized cytogen (if the SKU is a vial)Follow the COA fillDo the mathCapsules skip this step. Cytomax complexes are not this molecule.

Change vial size or water volume? Open the reconstitution calculator.

Safety & Considerations

Research peptide. Extensively used in Russian clinical protocols. Russian clinic history is not a US safety NDA.

Regulatory & Legal Status

FDA Status (US)
Research Only
WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

  • A defined sequence is not an FDA indication.
  • Gray-market identity is a live problem. HPLC beats a blog table.
  • Do not paste a sibling cytogen’s papers onto this SKU.
  • This site will not treat the named organ disease from a peptide page.

Verdict

Livagen is the synthetic KEDA cytogen for Liver. Khavinson’s group published in this family. That is a concentrated literature, not a Western Phase 3. Capsules and vials are different SKUs.

Interactions & Contraindications

Not a hepatitis or cirrhosis treatment page.

Synergies & Common Stacks

+ Svetinorm →

Cytogen vs liver Cytomax. Sequence vs mixture. Not interchangeable.

Frequently Asked Questions

Livagen vs Ovagen vs Svetinorm?▼
Livagen = KEDA. Ovagen = liver cytogen EDL (not ovary). Svetinorm = liver Cytomax.
Heterochromatin - is that proven in clinic?▼
It is a published experimental claim in Khavinson-group cell/lymphocyte work. It is not a billed epigenetic procedure.
Sequence?▼
Lys-Glu-Asp-Ala (KEDA).
Capsule or vial?▼
Both. Cytomed capsules swallow; research vials reconstitute for SubQ. Svetinorm is the liver Cytomax mixture - different class. Not a sublingual tablet.
Detox?▼
Not a 24-hour cleanse product.
What liver functions does Livagen restore?▼
Livagen targets hepatocyte chromatin to restore transcription of age-suppressed liver-specific genes. This improves liver metabolic enzyme production, detoxification capacity, and hepatocellular regeneration in aging individuals.

References

  1. Khavinson VKh et al. “Tissue-specific effects of peptides.” Bulletin of Experimental Biology and Medicine (2001). PMID: 11713572
  2. Khavinson VKh, Lin’kova NS, Tarnovskaya SI “Short peptides regulate gene expression.” Bulletin of Experimental Biology and Medicine (2016). PMID: 27909961
  3. Khavinson VKh, Morozov VG “Peptides of pineal gland and thymus prolong human life.” Neuroendocrinology Letters (2003). PMID: 14523363

📚 Related Articles

Epitalon: The Science of Telomerase Activation, Khavinson's Legacy, and Longevity Peptides
14 min read • Longevity
Where to get itOral bioregulator

Affiliate links: we earn a commission if you buy, at no extra cost to you.

Liverra is Vita-Stream's US-made liver bioregulator (Vita Peptides' own house line), a different product from Livagen. No trial has tested it.

Browse Liverra

Use code KymataLabs at checkout

See all sources and our full review

← Back to Peptide Library·Bioregulator stacks