Testosterone (TRT) and supplements: 2 sourced interactions
Testosterone therapy, also sold as AndroGel, Testim and Xyosted. Of these, 2 studied in people. Plus 4 predicted from how each works (not established). Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Testosterone (TRT) with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
1BiotinStudiedBiotin can make testosterone blood tests read falsely high
moderate · Studied in people (PubMed) · evidence C · Lab test interference
Excess biotin interferes with tests that use biotin–streptavidin binding; competitive tests read falsely high.
To raise with your pharmacist or prescriberTell your prescriber and the lab about biotin before testosterone checks, and ask how long to pause it first.
- PMID 29942920 · Stieglitz HM, J Endocr Soc 2018 · Case report
- PMID 32567529 · Moerman A, Acta Clin Belg 2022 · Narrative review
- Checked Oct 10, 2026
Minor
5DHEAStudiedDHEA adds androgen on top of testosterone therapy
minor · Studied in people (PubMed) · evidence B · Hormone conversion
DHEA is a precursor hormone the body can convert to testosterone.
To raise with your pharmacist or prescriberTell your prescriber if you take DHEA, so lab results and dosing account for it (inferred).
- PMID 33045358 · Li Y, Exp Gerontol 2020 · Systematic review and meta-analysis of RCTs
- Checked Oct 10, 2026
Asian ginsengPredictedBoth lower blood sugar, which may add up.
minor · Predicted from how each works, not established · Blood sugar lowering
Predicted from what each is known to do, not studied as a pair and not established.
Both lower blood sugar, which may add up.
- FDA drug label (DailyMed) · Testosterone (TRT): lowers blood sugar (DEPO-TESTOSTERONE (testosterone cypionate injection, USP) CIII [Pharmacia & Upjohn Company LLC / Pfizer], Precautions – Drug interactions)
- NIH National Center for Complementary and Integrative Health · Asian ginseng: lowers blood sugar (Asian Ginseng: Usefulness and Safety, What Do We Know About Safety?)
- Checked Oct 25, 2026
BerberinePredictedBoth lower blood sugar, which may add up.
minor · Predicted from how each works, not established · Blood sugar lowering
Predicted from what each is known to do, not studied as a pair and not established.
Both lower blood sugar, which may add up.
- FDA drug label (DailyMed) · Testosterone (TRT): lowers blood sugar (DEPO-TESTOSTERONE (testosterone cypionate injection, USP) CIII [Pharmacia & Upjohn Company LLC / Pfizer], Precautions – Drug interactions)
- LiverTox (NIH) · Berberine: lowers blood sugar (Berberine. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury (NIDDK), Background)
- Checked Oct 23, 2026
ChromiumPredictedBoth lower blood sugar, which may add up.
minor · Predicted from how each works, not established · Blood sugar lowering
Predicted from what each is known to do, not studied as a pair and not established.
Both lower blood sugar, which may add up.
- FDA drug label (DailyMed) · Testosterone (TRT): lowers blood sugar (DEPO-TESTOSTERONE (testosterone cypionate injection, USP) CIII [Pharmacia & Upjohn Company LLC / Pfizer], Precautions – Drug interactions)
- NIH Office of Dietary Supplements · Chromium: lowers blood sugar (Office of Dietary Supplements · Chromium, Interactions with Medications · Metformin and other antidiabetes medications)
- Checked Oct 25, 2026
Red yeast ricePredictedBoth lower blood sugar, which may add up.
minor · Predicted from how each works, not established · Blood sugar lowering
Predicted from what each is known to do, not studied as a pair and not established.
Both lower blood sugar, which may add up.
- FDA drug label (DailyMed) · Testosterone (TRT): lowers blood sugar (DEPO-TESTOSTERONE (testosterone cypionate injection, USP) CIII [Pharmacia & Upjohn Company LLC / Pfizer], Precautions – Drug interactions)
- NIH National Center for Complementary and Integrative Health · Red yeast rice: lowers blood sugar (Red Yeast Rice: What You Need To Know, Are red yeast rice products effective?)
- Checked Oct 25, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Testosterone (TRT) with everything else you take, together
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