Bifidobacterium longum

Also called B. longum, Bifidobacterium infantis 35624, B. infantis 35624, Align probiotic strain, BB536, B. longum 1714.

Best grade C across 12 graded outcomes Other Last checked

The short answer

From 15 sources

Bifidobacterium longum effects are strain-specific and modest. Strain 35624 eased IBS symptoms in 362 women at one dose only, and missed its main goal in 302 people with bloating. BB536 and strain 1714 trials missed their primary outcomes but improved secondary ones, such as stool frequency, early sleep quality and vitality.

Quick pick

Align Probiotic Capsules (strain 35624), 28 capsules

from HerbsPro

Label: 1 capsule: Bifidobacterium longum 35624, 10 mg (the listing does not state CFU).

Best for trying one bottle: $41.49 one-time (checked Oct 15, 2026).

Shop at HerbsPro (paid link, opens in new tab)

Partner links may earn us a commission. How partner links work

How we chose: Momentous is the partner brand we list first, so its product leads whenever the Where to buy list has one for this compound or a form in our Forms table. Otherwise, among partner brands that passed our vetting without conditions (others only when none sells it), the first product in that list whose name matches a form in our Forms table, else the first one listed. Not a claim that it works: check the amount per serving against the studied doses and limits.

Every graded outcome on this page

12 rows · line = participants
  1. Grade CIBS symptoms (abdominal pain, bloating, bowel habit)IBSn 362
  2. Grade CAbdominal discomfort and bloating in people not under a doctor's careIBSn 302
  3. Grade CDepressive symptoms in mild to moderate depressionMoodn 168
  4. Grade CSleep quality in adults with poor sleepSleepn 89
  5. Grade CChronic constipation in older adultsConstipationn 80
  6. Grade CHbA1c in type 2 diabetes on metformin (strain BL21)Blood sugarn 79
  7. Grade CDepression scores in IBS with anxiety or depressionMoodn 44
  8. Grade DVisceral fat in normal-weight and overweight adultsBody fatn 100
  9. Grade DAllergic rhinitis symptoms (strain CECT 7347, live and heat-killed)Allergiesn 72
  10. Grade DBrain activity and vitality under social stressMoodn 40
  11. Grade DInfluenza and fever in frail older adultsInfectionsn 27
  12. No effectAnxiety and depressive symptoms in pregnancy and after birthMoodn 184

Key facts

Strain matters
Health Canada requires the strain designation on probiotic labels; NCCIH notes one strain's effects do not carry over to others12
IBS (35624)
100 million CFU beat placebo on pain and bloating in 362 women, but 1 million and 10 billion CFU did not3
Constipation in older adults (BB536)
Primary score missed (P = 0.074); stool frequency improved (P = 0.008) in 80 adults with a mean age of 77.95
Sleep and mood (1714)
Primary outcomes missed in 89 and 168 adults; sleep quality and vitality improved at secondary time points78
Blood sugar (BL21)
Added to metformin for 12 weeks, BL21 lowered HbA1c more than placebo (p = 0.026) in 79 adults with type 2 diabetes14
Funding
Most strain trials were run or funded by the strain owners: Procter & Gamble (35624), Morinaga (BB536), Novonesis (1714), Nestle (NCC3001)467810

What it is

Bifidobacterium longum is a gut bacterium sold as a probiotic; its effects depend on the strain, such as 35624, BB536, 1714 or NCC3001.

How it works

Proposed

B. longum is a normal gut resident. Proposed effects run through the gut-brain axis: strain NCC3001 reduced brain responses to negative emotional stimuli on fMRI and strain 1714 altered resting brain oscillations on magnetoencephalography, without changing gut microbiota profiles or inflammatory markers in the NCC3001 trial.911

Forms, side by side

2 forms named in our sources. The rest show what our data holds, and say plainly where it holds nothing yet.

Bifidobacterium longum forms compared

2 forms
Bifidobacterium longum forms compared: 2 forms by 3 attributes. Empty cells are labelled No data yet, or Not graded in the evidence row.
2 formsSingle-strain B. longum capsules or powdersHeat-treated B. longum CECT 7347 (postbiotic)
Absorption in peopleNot absorbed; acts in the gut. NCC3001 was not detected in every participant after use.10Not absorbed; the cells are dead and act in the gut.15
GI toleranceNo significant adverse events in the 35624 IBS trial; few adverse events with BB536 in older adults.35Not reported in the abstract.15
Studied forIBS, constipation, sleep, mood and infections (strain-specific)Allergic rhinitis (beat placebo, while the live form did not)
  1. Single-strain B. longum capsules or powders
    Absorption in people
    Not absorbed; acts in the gut. NCC3001 was not detected in every participant after use.10
    GI tolerance
    No significant adverse events in the 35624 IBS trial; few adverse events with BB536 in older adults.35
    Studied for
    IBS, constipation, sleep, mood and infections (strain-specific)
  2. Heat-treated B. longum CECT 7347 (postbiotic)
    Absorption in people
    Not absorbed; the cells are dead and act in the gut.15
    GI tolerance
    Not reported in the abstract.15
    Studied for
    Allergic rhinitis (beat placebo, while the live form did not)
Every cell holds data from a cited page; citation numbers link to the page that holds them.Scroll the table for every column

What the human research says

Human trials only, one row per outcome. The form line shows what each trial actually tested. Grades follow our evidence-grading policy.

Trial map

12 graded outcomes, largest study first

12 graded outcomes: 5 improved, 6 mixed, 1 no effect. The largest, a 2006 randomized trial of 362 people on IBS symptoms (abdominal pain, bloating, bowel habit), found an improvement.

1. IBS symptoms (abdominal pain, bloating, bowel habit): improved, 362 people15. Visceral fat in normal-weight and overweight adults: improved, 100 people58. HbA1c in type 2 diabetes on metformin (strain BL21): improved, 79 people810. Depression scores in IBS with anxiety or depression: improved, 44 people1012. Influenza and fever in frail older adults: improved, 27 people12
2. Abdominal discomfort and bloating in people not under a doctor's care: mixed, 302 people24. Depressive symptoms in mild to moderate depression: mixed, 168 people46. Sleep quality in adults with poor sleep: mixed, 89 people67. Chronic constipation in older adults: mixed, 80 people79. Allergic rhinitis symptoms (strain CECT 7347, live and heat-killed): mixed, 72 people911. Brain activity and vitality under social stress: mixed, 40 people11
3. Anxiety and depressive symptoms in pregnancy and after birth: no effect, 184 people3

1IBS symptoms (abdominal pain, bloating, bowel habit)

Improved · Grade C · RCT, 362 people, 2006

Women with IBS of any subtype in UK primary care

Dose, result and source
Every graded outcome on this page, largest study first
OutcomeFoundPeopleStudyWho was studied
IBS symptoms (abdominal pain, bloating, bowel habit)Improved362Grade C · RCT, 2006Women with IBS of any subtype in UK primary care
Abdominal discomfort and bloating in people not under a doctor's careMixed302Grade C · RCT, 2017US adults with abdominal discomfort and bloating at least twice a week for 3 months (275 evaluable)
Anxiety and depressive symptoms in pregnancy and after birthNo effect184No-effect grade · RCT, 2025Pregnant women followed to 12 weeks after delivery (three arms)
Depressive symptoms in mild to moderate depressionMixed168Grade C · RCT, 2026Adults aged 18 to 70 with mild to moderate depression
Visceral fat in normal-weight and overweight adultsImproved100Grade D · RCT, 2024Adults aged 29 to 64 with BMI between 23 and 30 (Japan)
Sleep quality in adults with poor sleepMixed89Grade C · RCT, 2024Adults aged 18 to 45 with a Pittsburgh Sleep Quality Index of 5 or more
Chronic constipation in older adultsMixed80Grade C · RCT, 2023Older adults with chronic constipation in Japan (mean age 77.9)
HbA1c in type 2 diabetes on metformin (strain BL21)Improved79Grade C · RCT, 2026Adults with type 2 diabetes taking metformin
Allergic rhinitis symptoms (strain CECT 7347, live and heat-killed)Mixed72Grade D · RCT, 2026Adults aged 18–60 with moderate to severe allergic rhinitis on first-line medicines
Depression scores in IBS with anxiety or depressionImproved44Grade C · Pilot RCT, 2017Adults with IBS (diarrhoea or mixed) and mild to moderate anxiety or depression (McMaster University)
Brain activity and vitality under social stressMixed40Grade D · RCT, 2019Healthy volunteers (Tubingen, Germany)
Influenza and fever in frail older adultsImproved27Grade D · RCT, 2010Older adults with a mean age of 86.7, vaccinated against influenza
Each circle is one graded outcome on this page, numbered from the largest study down, and placed by how many people it studied (log scale). It shows who was studied and what was found, not advice about your dose.

Every graded row

12 rows

Showing 12 of 12 outcomes. Human trials only.

Grade CIBS symptoms (abdominal pain, bloating, bowel habit)IBSLess pain and bloating at one dose (100 million CFU)RCT
n 362 · 2006

Improved 100 million CFU was superior to placebo and to the other doses for abdominal pain, composite score, bloating, bowel dysfunction, incomplete evacuation, straining and gas; global relief exceeded placebo by more than 20% (p < 0.02). The 1 million and 10 billion CFU doses did not differ from placebo; the 10 billion CFU capsule had formulation problems.

Design
RCT, n = 362, 2006
Population
Women with IBS of any subtype in UK primary care
Form
B. infantis 35624 capsules
Dose
1 million, 100 million or 10 billion CFU/day vs placebo
Duration
4 weeks
Source
Reference 3 · PubMed 16863564 (opens PubMed)
Grade CAbdominal discomfort and bloating in people not under a doctor's careIBSNo difference in severity; more bloating-free daysRCT
n 302 · 2017

Mixed Symptom severity improved in both groups with no difference between probiotic and placebo (P > 0.3); the probiotic group had more bloating-free days (P < 0.05).

Design
RCT, n = 302, 2017
Population
US adults with abdominal discomfort and bloating at least twice a week for 3 months (275 evaluable)
Form
B. infantis 35624 capsules
Dose
1 billion CFU/day
Duration
4 weeks
Source
Reference 4 · PubMed 27845337 (opens PubMed)
Grade CDepressive symptoms in mild to moderate depressionMoodPrimary depression score unchanged; some week-4 gainsRCT
n 168 · 2026

Mixed The primary outcome, Beck Depression Inventory-II change, did not differ from placebo at week 4 (P = .718) or week 8 (P = .132). Sleep quality and PHQ-9 improved more at week 4 only; vitality stayed better at week 8 (P = .042).

Design
RCT, n = 168, 2026
Population
Adults aged 18 to 70 with mild to moderate depression
Form
B. longum 1714
Dose
10 billion CFU/day
Duration
8 weeks
Source
Reference 8 · PubMed 42060410 (opens PubMed)
Grade CSleep quality in adults with poor sleepSleepFaster early improvement; no difference at 8 weeksRCT
n 89 · 2024

Mixed PSQI global score, the primary outcome, improved in both groups. The sleep-quality component and daytime dysfunction improved more with 1714 at week 4, and social functioning and vitality at week 8; actigraphy did not change. Overall 8-week improvement was similar in both groups.

Design
RCT, n = 89, 2024
Population
Adults aged 18 to 45 with a Pittsburgh Sleep Quality Index of 5 or more
Form
B. longum 1714
Dose
Once daily (CFU not stated in the abstract)
Duration
8 weeks
Source
Reference 7 · PubMed 38355674 (opens PubMed)
Grade CChronic constipation in older adultsConstipationPrimary score missed; more frequent bowel movementsRCT
n 80 · 2023

Mixed The primary outcome, change in constipation score vs placebo, was not significant (P = 0.074). Stool frequency improved vs placebo (P = 0.008) and failure of evacuation showed a trend (P = 0.051). Few probiotic-related adverse events.

Design
RCT, n = 80, 2023
Population
Older adults with chronic constipation in Japan (mean age 77.9)
Form
B. longum BB536
Dose
50 billion CFU once daily
Duration
4 weeks
Source
Reference 5 · PubMed 36216361 (opens PubMed)
Grade CHbA1c in type 2 diabetes on metformin (strain BL21)Blood sugarImprovedRCT
n 79 · 2026

Improved HbA1c, the primary outcome, fell more than with placebo (p = 0.026); the full text gives a median change of −0.3 vs 0.0 percentage points. Fasting glucose and insulin resistance showed non-significant trends. Tolerability was similar to placebo.

Design
RCT, n = 79, 2026
Population
Adults with type 2 diabetes taking metformin
Form
B. longum subsp. longum BL21
Dose
20 billion CFU a day
Duration
12 weeks
Source
Reference 14 · PubMed 41523285 (opens PubMed)
Grade CDepression scores in IBS with anxiety or depressionMoodMore depression responders; no change in IBS symptomsPilot RCT
n 44 · 2017

Improved 14 of 22 on the probiotic vs 7 of 22 on placebo had depression scores fall by 2 or more points (P = .04); quality of life rose. No effect on anxiety or IBS symptoms.

Design
Pilot RCT, n = 44, 2017
Population
Adults with IBS (diarrhoea or mixed) and mild to moderate anxiety or depression (McMaster University)
Form
B. longum NCC3001
Dose
Daily (CFU not stated in the abstract)
Duration
6 weeks
Source
Reference 11 · PubMed 28483500 (opens PubMed)
Grade DVisceral fat in normal-weight and overweight adultsBody fatLess visceral fat vs placebo (blend)RCT
n 100 · 2024

Improved Abdominal visceral fat area, total abdominal fat area and serum triglycerides fell compared with placebo, and the BMI rise seen with placebo was suppressed.

Design
RCT, n = 100, 2024
Population
Adults aged 29 to 64 with BMI between 23 and 30 (Japan)
Form
Two-strain blend: B. longum BB536 plus B. breve MCC1274
Dose
10 billion CFU BB536 plus 5 billion CFU MCC1274 daily
Duration
16 weeks
Source
Reference 12 · PubMed 38542727 (opens PubMed)
Grade DAllergic rhinitis symptoms (strain CECT 7347, live and heat-killed)AllergiesMixedRCT
n 72 · 2026

Mixed The heat-treated form lowered the combined symptom and medication score by 0.6 points more than placebo (CI 0.09 to 1.12), a 33% greater reduction. The live form had a non-significant effect.

Design
RCT, n = 72, 2026
Population
Adults aged 18–60 with moderate to severe allergic rhinitis on first-line medicines
Form
B. longum CECT 7347, live (probiotic) or heat-treated (postbiotic)
Dose
Daily (amount not stated in the abstract)
Duration
8 weeks
Source
Reference 15 · PubMed 42047238 (opens PubMed)
Grade DBrain activity and vitality under social stressMoodBrain-activity changes; no behavioural effectRCT
n 40 · 2019

Mixed 1714 altered resting brain oscillations, which tracked with vitality changes, and altered responses during a social-stress game; there was no effect on stress at the behavioural level, which the authors attribute to small numbers.

Design
RCT, n = 40, 2019
Population
Healthy volunteers (Tubingen, Germany)
Form
B. longum 1714
Dose
1 billion CFU/day
Duration
4 weeks
Source
Reference 9 · PubMed 30998517 (opens PubMed)
Grade DInfluenza and fever in frail older adultsInfectionsFewer influenza and fever casesRCT
n 27 · 2010

Improved A smaller proportion caught influenza and had fever with BB536 than with placebo; NK cell and neutrophil activity tended to stay slightly higher.

Design
RCT, n = 27, 2010
Population
Older adults with a mean age of 86.7, vaccinated against influenza
Form
B. longum BB536 in a test food
Dose
100 billion CFU/day
Duration
5 weeks open-label, then 14 weeks randomised
Source
Reference 6 · PubMed 20460726 (opens PubMed)
No effectAnxiety and depressive symptoms in pregnancy and after birthMoodNo effect on moodRCT
n 184 · 2025

No effect No differences between groups in depressive (EPDS) or anxiety (STAI) scores; the strain was not detected in all participants after the intervention.

Design
RCT, n = 184, 2025
Population
Pregnant women followed to 12 weeks after delivery (three arms)
Form
B. longum NCC3001
Dose
Daily (CFU not stated in the abstract)
Duration
From about 30 weeks of pregnancy, or from birth, until 12 weeks after delivery
Source
Reference 10 · PubMed 40175540 (opens PubMed)

What the numbers add up to

Each point is worked out from the data and the sources numbered on this page, with the arithmetic shown under it. It adds no new data and is not medical advice.

Missed primaries, positive extras

The BB536 constipation trial and both 1714 trials missed their main outcomes; the benefits reported are secondary measures or early time points.578

How we got this: Primary and secondary results of the cited RCTs

35624 alone did not hold up in pooled data

A 2017 meta-analysis found that single-strain B. infantis 35624 did not improve abdominal pain, bloating or bowel satisfaction across 3 trials; only multi-strain products containing it did.13

How we got this: Pooled results of the 2017 meta-analysis

Studied doses

Doses used in research, shown against the official limits. They describe the studies, not a recommendation for you.

Studied doses in research, not advice. These are amounts used in research, not personal advice. Your clinician or pharmacist can say what fits you.

Doses studied in human trials

Doses studied in human trials ranged from 100 million CFU a day of strain 35624, the only effective dose in its IBS trial, to 100 billion CFU a day of BB536 in frail older adults, mostly for 4 to 12 weeks; BL21 was tested at 20 billion CFU a day for 12 weeks.36714

When trials measured an effect

1 outcome
How long trials ran before effects were measured
OutcomeMeasured atBasis
Sleep quality and mood (strain 1714)Week 4 for secondary sleep-quality and PHQ-9 measures; neither trial's primary outcome beat placebo, and by week 8 mainly vitality still differedTwo RCTs (89 poor sleepers; 168 adults with low mood): sleep-quality and PHQ-9 gains versus placebo at week 478
When each outcome was assessed in the cited trials. It is not a promise of when anyone will notice a change.

Interactions and safety

Published interactions only: each row cites a source. No row means none was found in our sources, not that a combination is safe.

What Bifidobacterium longum meets

1 cited row 9 tested together

Medicines 1

Bifidobacterium longum1 medicine · 4 supplements

Supplements and foods 4

  • Drug label or FDA notice
  • Tested together in a graded trial
Also cited: 9 tested together

  1. Antibiotics

    • Drug labelDrug label or FDA notice

      Antibiotics, for example any oral antibiotic course: Health Canada's probiotic monograph requires labels for bacterial probiotics, including B. longum, to direct use at least 2–3 hours before or after antibiotics.

      Source 1, Health Canada, Natural and Non-prescription Health Products Directorate (2026)

  2. Akkermansia muciniphilaAkkermansia muciniphila page

  3. Bifidobacterium breveBifidobacterium breve page

  4. Lactobacillus gasseriLactobacillus gasseri page

  5. Lactobacillus helveticusLactobacillus helveticus page

Rows as our evidence profiles cite them; links stay on this site. Line weight shows what backs a row, not how serious an interaction is. No line means none was found in our sources, not that a combination is safe. Not medical advice: ask your pharmacist.

Interactions

1 agent
Published interactions, grouped by kind
AgentWhat the source saysEvidence
Medicines1
Antibioticse.g. any oral antibiotic courseHealth Canada's probiotic monograph requires labels for bacterial probiotics, including B. longum, to direct use at least 2–3 hours before or after antibiotics.1Drug label

Check with what you take

Kept on this device only

Add what you take. We list every interaction our evidence profiles cite between Bifidobacterium longum and your picks, and between your picks.

Most cited:

Add a supplement or medicine you take to check it against Bifidobacterium longum.

Starting from one medicine? The interaction checker rates how serious each pair is, on a curated list of 19 entries for 11 medicines. This cabinet has no severity rating: it lists every interaction row our supplement pages cite.

Not medical advice, and no dosing advice. An empty result means no row we cite names that pair, by name or through a drug class we can link the medicine to, not that a combination is safe. Where our sources name only a group of medicines we cannot match, the cabinet says so. Ask your pharmacist before you combine supplements and medicines.

Who should be careful

4 groups
Immune-compromised conditions
Health Canada's probiotic monograph: do not use if you have an immune-compromised condition (for example AIDS, lymphoma, or long-term corticosteroid treatment).1
Fever or severe gut symptoms
Health Canada: ask a health care practitioner before use if you have fever, vomiting, bloody diarrhoea or severe abdominal pain, and stop if digestive upset occurs, worsens or lasts beyond 3 days.1
Premature infants and seriously ill people
NCCIH reports severe or fatal infections in premature infants given probiotics, and higher risk in people with severe illness.2
Pregnancy and breastfeeding
LactMed has no probiotic entry. In a 184-woman randomized trial, strain NCC3001 taken from about 30 weeks of pregnancy (or from birth) until 12 weeks after delivery did not change anxiety or depression scores; the abstract does not report safety outcomes.10
Talk to your pharmacist or clinician before starting a supplement, especially if you take prescription medicines.

How to read the label

What to check on the Supplement Facts panel.

How to read the label

2 checks
Look for the strain code

Health Canada requires the strain designation on probiotic labels. Evidence here belongs to 35624, BB536, 1714, NCC3001, BL21 or CECT 7347, not to B. longum in general.1

More CFU is not always better

In the 35624 IBS trial only 100 million CFU worked; 10 billion CFU did not beat placebo.3

Where to buy Bifidobacterium longum

Products from brands we partner with that contain Bifidobacterium longum. Check the amount per serving against the doses studied above, and the label for other ingredients.

Bifidobacterium longum products from partner brands

1 product
  • Quick pickHerbsProAlign Probiotic Capsules (strain 35624), 28 capsules

    1 capsule: Bifidobacterium longum 35624, 10 mg (the listing does not state CFU)

    $41.49one-timeChecked Oct 15, 2026
    Shop at HerbsPro (paid link, opens in new tab)

Listing a product is not a claim that it works; check the amount per serving against the doses studied, and the label for other ingredients.Prices and labels are from each brand’s own site on the date shown; confirm before you buy.

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Frequently asked questions

Short answers to common questions; the numbers link to the sources below.

Common questions

5 answers
Does Bifidobacterium longum help IBS?

Strain 35624 at 100 million CFU eased pain and bloating in 362 women over 4 weeks, but other doses did not work, a 302-person bloating trial missed its main outcome, and a 2017 meta-analysis found no benefit for the single strain.3413

Can B. longum help with constipation?

BB536 at 50 billion CFU a day for 4 weeks increased stool frequency in older adults, but the main constipation score did not differ significantly from placebo (P = 0.074).5

Does B. longum 1714 help sleep or mood?

Partly. In 89 poor sleepers it sped early sleep-quality gains, but 8-week results matched placebo; in 168 adults with depression the main depression score did not change.78

Can B. longum be taken with antibiotics?

Health Canada's probiotic monograph says bacterial probiotics, B. longum included, should be taken at least 2–3 hours before or after antibiotics. It also says not to use probiotics with an immune-compromised condition.1

Is Align the same as B. infantis 35624?

The Align capsules we list name strain 35624 on the label, the strain number tested as B. infantis 35624 in the IBS trials. Procter & Gamble, which sells Align, co-authored the 2017 bloating trial.34

Sources

15 sources: trial abstracts, NIH fact sheets and reference databases. Numbers in the text link here.

Sources cited on this page

15 sources
  1. 1Probiotics (Natural Health Product monograph, April 24, 2026)Guideline Health Canada, Natural and Non-prescription Health Products Directorate, 2026 · webprod.hc-sc.gc.ca
  2. 2Probiotics: Usefulness and SafetyFact sheet National Center for Complementary and Integrative Health (NCCIH), 2019 · nccih.nih.gov
  3. 3Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome.RCT Am J Gastroenterol, 2006 · PMID 16863564
  4. 4Multi-Center, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Evaluate the Benefit of the Probiotic Bifidobacterium infantis 35624 in Non-Patients With Symptoms of Abdominal Discomfort and Bloating.RCT Am J Gastroenterol, 2017 · PMID 27845337
  5. 5Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial.RCT Am J Gastroenterol, 2023 · PMID 36216361
  6. 6Effects of Bifidobacterium longum BB536 administration on influenza infection, influenza vaccine antibody titer, and cell-mediated immunity in the elderly.RCT Biosci Biotechnol Biochem, 2010 · PMID 20460726
  7. 7Bifidobacterium longum 1714 improves sleep quality and aspects of well-being in healthy adults: a randomized, double-blind, placebo-controlled clinical trial.RCT Sci Rep, 2024 · PMID 38355674
  8. 8Effects of Bifidobacterium longum 1714 on low mood and related symptoms: A randomized, double-blind, placebo-controlled trial.RCT Exp Clin Psychopharmacol, 2026 · PMID 42060410
  9. 9Bifidobacterium longum 1714™ Strain Modulates Brain Activity of Healthy Volunteers During Social Stress.RCT Am J Gastroenterol, 2019 · PMID 30998517
  10. 10The impact of ingestion of Bifidobacterium longum NCC3001 on perinatal anxiety and depressive symptoms: a randomized controlled trial.RCT Sci Rep, 2025 · PMID 40175540
  11. 11Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome.Pilot RCT Gastroenterology, 2017 · PMID 28483500
  12. 12Effects of Bifidobacterium longum BB536 and Bifidobacterium breve MCC1274 on Body Composition in Normal and Overweight Adults in Randomized Placebo-Controlled Study.RCT Nutrients, 2024 · PMID 38542727
  13. 13Efficacy of Bifidobacterium infantis 35624 in patients with irritable bowel syndrome: a meta-analysis.Meta-analysis Curr Med Res Opin, 2017 · PMID 28166427
  14. 14Probiotic Supplementation With Bifidobacterium longum Subsp. Longum BL21 Improves Glycemic Control and Modulates Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial.RCT Food Sci Nutr, 2026 · PMID 41523285
  15. 15Effects of Live and Heat-Treated Bifidobacterium longum CECT 7347 in Adults With Allergic Rhinitis: A Randomised, Double-Blind, Placebo-Controlled Trial.RCT Allergy, 2026 · PMID 42047238

What changed

Every dated change to this page: what changed, who made it and why.

Change log

2 entries
Dated changes to this page
DateChangeWho and why
evidence, key facts, studied doses, interactions, who should avoid, forms, time to effect, FAQ, questions, relatedAdded two strain-named 2026 trials: BL21 with metformin for HbA1c in 79 adults with type 2 diabetes (grade C; n and dose from full text) and live versus heat-treated CECT 7347 for allergic rhinitis in 72 adults (grade D; only the heat-treated form beat placebo). Added the Health Canada antibiotic-spacing direction, a pregnancy and breastfeeding note citing the NCC3001 perinatal trial (LactMed and LiverTox have no probiotic entry), a heat-treated form row, a week-4 time-to-effect row for strain 1714, page questions, and links to B. breve, B. lactis and the gut and sleep goal hubs. Replaced the "Who should not use" FAQ, which repeated an auto-derived question, with antibiotics. Not added: a 56-person CCFM1112 constipation trial (analysed n and dose not in the abstract) and an exploratory BB536 trial in athletes (no between-group differences).Writer: Kymata Health EditorialTrigger: A–Z audit against docs/supplements/AUDIT-STANDARD.md
allInitial editorial evidence review. Every PMID checked against NCBI E-utilities esummary (title, year, journal; none retracted) and each cited abstract read; numbers taken from the abstracts. Funding disclosed per row: Procter & Gamble co-authored the 35624 bloating trial, Morinaga authored or funded the BB536 trials, Novonesis/Novozymes/PrecisionBiotics the 1714 trials and Nestle the perinatal NCC3001 trial. Safety from Health Canada's Probiotics monograph (2026-04-24) and NCCIH's Probiotics: Usefulness and Safety. Where to buy: Align (listing checked 2026-10-15).Writer: Kymata Health EditorialTrigger: new page

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