Mitochondrial

SHLP2

Small humanin-like peptide 2 · SHLP-2

Small humanin-like peptide 2 - another mitochondrial ORF peptide in the same family as humanin (which we list). Characterized in Cobb et al. 2016 as an MDP with metabolic/cell-survival signals distinct from humanin. Research SKU. Not a second humanin, not MOTS-c.

Not FDA-approved - research chemical

Quick answer

What it is: Small humanin-like peptide 2 - another mitochondrial ORF peptide in the same family as humanin (which we list).

Typical research dose: Research; no established human dose

Reconstitution calculator ↓

Research summary, not medical advice.

Reviewed by Kymata Health Editorial Team
Last updated: August 2026Evidence: Low
Typical research dose
Research; no established human dose
Frequency
Not established
Half-life
Unknown (SKU unpublished)
Common vials
5 mg
CAS
N/A

Use-case scores

0–10 against the evidence we have, not a gym ranking. Hidden domains do not apply here.

  • Longevity / aging1.5/10

    Cobb 2016 isoform paper. Not a second humanin protocol.

Compound card

Class
Small humanin-like peptide 2 (MDP)
Formula
Small humanin-like peptide 2
Status
Not FDA-approved · research use
Dose it
5 mg + 2 mL BAC water → 2.5 mg/mL · 500 mcg ≈ 20 units (U-100)
Open in calculator

How it works

SHLP2 is a small humanin-like peptide encoded as a mitochondrial ORF, characterized with other SHLPs in Cobb et al. 2016 (PMID 27070352). It is not humanin, not MOTS-c, not SS-31.

Isoform-specific cell effects in that paper are why we keep a separate ID instead of aliasing it onto humanin.

Source: PMID: 27070352 (Cobb / Cohen MDP paper)

Research Use Cases

  • ✓MDP identity: Low

Dosing

PhaseDoseFrequencyNotes
HumanNone establishedn/aDo not copy humanin milligrams onto SHLP2.

Administration

Route / form
Research SC (vendor)
Timing
Not established.
Empty stomach?
No - Food timing is not critical.

Timeline

Cell / MDP papers
Not a consumer longevity curve.

Who it is for

MDP identity

Low

Sibling to humanin in the catalog sense. Different ORF peptide.

Reconstitution

VialWaterConcentrationExample dose
5 mg lyophilized2 mL BAC2.5 mg/mLResearch SKU. No labeled example dose.

Change vial size or water volume? Open the reconstitution calculator.

Safety & Considerations

Research MDP. No approved indication. Unknown SKU identity on gray-market vials.

Regulatory & Legal Status

FDA Status (US)
Research Only

Mitochondrial ORF peptide (humanin-like). No FDA program

WADA Status (2026)
Not Listed

Not currently on the WADA 2026 Prohibited List. Policies may change - verify before competition.

Classification

Research Chemical

US Compounding: Not eligible / not available

⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.

Limits of current evidence

  • No established human dose.

Verdict

SHLP2 is a distinct MDP from humanin. Transferring humanin doses here is a category error.

Interactions & Contraindications

Research MDP. No approved indication. Unknown SKU identity on gray-market vials.

SHLP2 vs. Humanin

Canonical comparison: SHLP2 vs Humanin

AttributeSHLP2Humanin
IdentitySmall humanin-like peptide 2Humanin (24-aa MDP)
PaperCobb et al. 2016 (PMID 27070352)Hashimoto / MDP discovery trail
Dose transferDo not copy humanin mg onto SHLP2Community ranges are already unlabeled

Verdict: Same mitochondrial neighborhood, different ORF peptide. SHLP2 is not a humanin nickname.

Frequently Asked Questions

Is SHLP2 a type of humanin?▼
It is a related mitochondrial ORF peptide, not a humanin truncation. Separate sequence, separate ID.

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