Naproxen and supplements: 1 sourced interaction
NSAID, also sold as Aleve and Naprosyn. Of these, 1 named by an FDA label or NIH page. Plus 6 predicted from how each works (not established). Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Naproxen with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
7MagnesiumLabel or NIHThe FDA label names this pair (absorption in the gut).
moderate · Named by an FDA label or NIH page · Absorption in the gut
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Concomitant administration of some antacids (magnesium oxide or aluminum hydroxide) and sucralfate can delay the absorption of naproxen.”
- FDA drug label (DailyMed) · NAPROXEN TABLET [GRANULES PHARMACEUTICALS INC.] (Rx), section 7
- Checked Oct 23, 2026
Asian ginsengPredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- FDA drug label (DailyMed) · Naproxen: affects clotting or platelets (NAPROXEN TABLET [GRANULES PHARMACEUTICALS INC.] (Rx), section 7 (Drug/Laboratory Test Interactions: Bleeding times))
- NIH National Center for Complementary and Integrative Health · Asian ginseng: affects clotting or platelets (Asian Ginseng: Usefulness and Safety, What Do We Know About Safety?)
- Checked Oct 25, 2026
Fish oil (omega-3)PredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- NIH Office of Dietary Supplements · Fish oil (omega-3): affects clotting or platelets (Office of Dietary Supplements · Omega-3 Fatty Acids: Fact Sheet for Health Professionals, Interactions with Medications > Warfarin (Coumadin) and similar anticoagulants)
- FDA drug label (DailyMed) · Naproxen: affects clotting or platelets (NAPROXEN TABLET [GRANULES PHARMACEUTICALS INC.] (Rx), section 7 (Drug/Laboratory Test Interactions: Bleeding times))
- Checked Oct 23, 2026
GarlicPredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- NIH National Center for Complementary and Integrative Health · Garlic: affects clotting or platelets (Garlic: Usefulness and Safety, What Do We Know About Safety?)
- FDA drug label (DailyMed) · Naproxen: affects clotting or platelets (NAPROXEN TABLET [GRANULES PHARMACEUTICALS INC.] (Rx), section 7 (Drug/Laboratory Test Interactions: Bleeding times))
- Checked Oct 23, 2026
Ginkgo bilobaPredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- NIH National Center for Complementary and Integrative Health · Ginkgo biloba: affects clotting or platelets (Ginkgo: Usefulness and Safety, What Do We Know About Safety?)
- FDA drug label (DailyMed) · Naproxen: affects clotting or platelets (NAPROXEN TABLET [GRANULES PHARMACEUTICALS INC.] (Rx), section 7 (Drug/Laboratory Test Interactions: Bleeding times))
- Checked Oct 23, 2026
Potassium (supplements / salt substitutes)PredictedBoth can raise potassium, which may add up.
moderate · Predicted from how each works, not established · Potassium level
Predicted from what each is known to do, not studied as a pair and not established.
Both can raise potassium, which may add up.
- FDA drug label (DailyMed) · Naproxen: raises potassium (NAPROXEN TABLET [GRANULES PHARMACEUTICALS INC.] (Rx), section 5.6)
- NIH Office of Dietary Supplements · Potassium (supplements / salt substitutes): raises potassium (Office of Dietary Supplements · Potassium, Health Risks from Excessive Potassium · Potassium from dietary supplements, salt substitutes, and medications)
- Checked Oct 25, 2026
Vitamin EPredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- FDA drug label (DailyMed) · Naproxen: affects clotting or platelets (NAPROXEN TABLET [GRANULES PHARMACEUTICALS INC.] (Rx), section 7 (Drug/Laboratory Test Interactions: Bleeding times))
- NIH Office of Dietary Supplements · Vitamin E: affects clotting or platelets (Office of Dietary Supplements · Vitamin E, Interactions with Medications · Anticoagulant and antiplatelet medications)
- Checked Oct 25, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Naproxen with everything else you take, together
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