Ibuprofen and supplements: what’s known

NSAID, also sold as Advil and Motrin. There are 5 predicted from how each works (not established). Each links its source and the date it was checked.

From the Interaction Map Sources checked Oct 25, 2026

A combination missing here is not on our list; that does not mean it is safe together.

Ibuprofen with supplements

Most serious first. Open a row for the mechanism, the source's words and the date checked.

Educational only. Check with your pharmacist or prescriber before changing anything you take.

Moderate

5
Asian ginsengPredictedBoth can affect clotting or platelets, so bleeding risk may add up.

moderate · Predicted from how each works, not established · Platelets and bleeding

Predicted from what each is known to do, not studied as a pair and not established.

Both can affect clotting or platelets, so bleeding risk may add up.

Fish oil (omega-3)PredictedBoth can affect clotting or platelets, so bleeding risk may add up.

moderate · Predicted from how each works, not established · Platelets and bleeding

Predicted from what each is known to do, not studied as a pair and not established.

Both can affect clotting or platelets, so bleeding risk may add up.

  • NIH Office of Dietary Supplements · Fish oil (omega-3): affects clotting or platelets (Office of Dietary Supplements · Omega-3 Fatty Acids: Fact Sheet for Health Professionals, Interactions with Medications > Warfarin (Coumadin) and similar anticoagulants)
  • FDA drug label (DailyMed) · Ibuprofen: affects clotting or platelets (IBUPROFEN TABLET, FILM COATED [GRANULES INDIA LIMITED] (Rx), PRECAUTIONS · Hematological effects)
  • Checked Oct 23, 2026
GarlicPredictedBoth can affect clotting or platelets, so bleeding risk may add up.

moderate · Predicted from how each works, not established · Platelets and bleeding

Predicted from what each is known to do, not studied as a pair and not established.

Both can affect clotting or platelets, so bleeding risk may add up.

Ginkgo bilobaPredictedBoth can affect clotting or platelets, so bleeding risk may add up.

moderate · Predicted from how each works, not established · Platelets and bleeding

Predicted from what each is known to do, not studied as a pair and not established.

Both can affect clotting or platelets, so bleeding risk may add up.

Vitamin EPredictedBoth can affect clotting or platelets, so bleeding risk may add up.

moderate · Predicted from how each works, not established · Platelets and bleeding

Predicted from what each is known to do, not studied as a pair and not established.

Both can affect clotting or platelets, so bleeding risk may add up.

  • FDA drug label (DailyMed) · Ibuprofen: affects clotting or platelets (IBUPROFEN TABLET, FILM COATED [GRANULES INDIA LIMITED] (Rx), PRECAUTIONS · Hematological effects)
  • NIH Office of Dietary Supplements · Vitamin E: affects clotting or platelets (Office of Dietary Supplements · Vitamin E, Interactions with Medications · Anticoagulant and antiplatelet medications)
  • Checked Oct 25, 2026

How these lines are sourced

Three kinds of line

  • Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
  • Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
  • Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.

Interaction MapCheck Ibuprofen with everything else you take, together

Educational only. Not medical advice. Some links earn us a commission: kymatahealth.com/affiliate-disclosure.