Digoxin and supplements: 1 sourced interaction
Cardiac glycoside, also sold as Lanoxin and Digitek. Of these, 1 named by an FDA label or NIH page. Plus 4 predicted from how each works (not established). Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Digoxin with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
1St John's wortLabel or NIHThe FDA label names this pair (platelets and bleeding).
moderate · Named by an FDA label or NIH page · Platelets and bleeding
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“For example, St. John’s wort can weaken the effects of many medicines, including crucially important medicines”
“As a result, St. John’s wort has major drug interactions, particularly with birth control pills, transplant rejection agents, antiretroviral agents, digoxin, platelet inhibitors, anticoagulants and psychotropic agents.”
“Measure serum digoxin concentrations before initiating concomitant drugs. Continue monitoring and increase digoxin dose by approximately 20-40% as necessary.”
- NIH National Center for Complementary and Integrative Health · St. John’s Wort: Usefulness and Safety, What Do We Know About Safety?
- LiverTox (NIH) · St. John's Wort. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury (NIDDK), Background
- FDA drug label (DailyMed) · LANOXIN (DIGOXIN) TABLET [ADVANZ PHARMA (US) CORP.], section 7.2
- Checked Oct 25, 2026
Minor
4CalciumPredictedTaken together, Calcium may cut how much Digoxin is absorbed; spacing them apart is usually discussed.
minor · Predicted from how each works, not established · Absorption in the gut
Predicted from what each is known to do, not studied as a pair and not established.
Taken together, Calcium may cut how much Digoxin is absorbed; spacing them apart is usually discussed.
- NIH Office of Dietary Supplements · Calcium: binds medicines in the gut (Office of Dietary Supplements · Calcium: Fact Sheet for Health Professionals, Interactions with Medications > Dolutegravir)
- FDA drug label (DailyMed) · Digoxin: absorption affected by other products (LANOXIN (DIGOXIN) TABLET [ADVANZ PHARMA (US) CORP.], section 12.3)
- Checked Oct 25, 2026
IronPredictedTaken together, Iron may cut how much Digoxin is absorbed; spacing them apart is usually discussed.
minor · Predicted from how each works, not established · Absorption in the gut
Predicted from what each is known to do, not studied as a pair and not established.
Taken together, Iron may cut how much Digoxin is absorbed; spacing them apart is usually discussed.
- NIH Office of Dietary Supplements · Iron: binds medicines in the gut (Office of Dietary Supplements · Iron: Fact Sheet for Health Professionals, Interactions with Medications > Levodopa)
- FDA drug label (DailyMed) · Digoxin: absorption affected by other products (LANOXIN (DIGOXIN) TABLET [ADVANZ PHARMA (US) CORP.], section 12.3)
- Checked Oct 25, 2026
MagnesiumPredictedTaken together, Magnesium may cut how much Digoxin is absorbed; spacing them apart is usually discussed.
minor · Predicted from how each works, not established · Absorption in the gut
Predicted from what each is known to do, not studied as a pair and not established.
Taken together, Magnesium may cut how much Digoxin is absorbed; spacing them apart is usually discussed.
- NIH Office of Dietary Supplements · Magnesium: binds medicines in the gut (Office of Dietary Supplements · Magnesium: Fact Sheet for Health Professionals, Interactions with Medications > Antibiotics)
- FDA drug label (DailyMed) · Digoxin: absorption affected by other products (LANOXIN (DIGOXIN) TABLET [ADVANZ PHARMA (US) CORP.], section 12.3)
- Checked Oct 25, 2026
ZincPredictedTaken together, Zinc may cut how much Digoxin is absorbed; spacing them apart is usually discussed.
minor · Predicted from how each works, not established · Absorption in the gut
Predicted from what each is known to do, not studied as a pair and not established.
Taken together, Zinc may cut how much Digoxin is absorbed; spacing them apart is usually discussed.
- NIH Office of Dietary Supplements · Zinc: binds medicines in the gut (Office of Dietary Supplements · Zinc: Fact Sheet for Health Professionals, Interactions with Medications > Antibiotics)
- FDA drug label (DailyMed) · Digoxin: absorption affected by other products (LANOXIN (DIGOXIN) TABLET [ADVANZ PHARMA (US) CORP.], section 12.3)
- Checked Oct 25, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Digoxin with everything else you take, together
Keep reading: Supplements and vitamins
Supplements and vitamins: every pageSupplement & Nutrient EncyclopediaBrowse all topics
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- Next in this topicDuloxetine and supplements: 2 sourced interactionsDuloxetine (Cymbalta, Drizalma Sprinkle) with supplements, by severity, each line studied in people or named by an FDA label or NIH page, with its source.
- St. John's wortSt.
- Interaction MapCheck several medicines and supplements at once, each interaction sourced to PubMed, FDA labels or NIH; a pair we have no source for reads as not on our list, never as safe.