Clopidogrel and supplements: 3 sourced interactions
Antiplatelet, also sold as Plavix. Of these, 3 named by an FDA label or NIH page. Plus 3 predicted from how each works (not established). Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Clopidogrel with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
6Ginkgo bilobaLabel or NIHAn NIH page names this pair (platelets and bleeding).
moderate · Named by an FDA label or NIH page · Platelets and bleeding
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Several instances of excessive bleeding during therapy with ginkgo have been attributed to drug interactions with antiplatelet medications or anticoagulants.”
- LiverTox (NIH) · Ginkgo. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury (NIDDK), Hepatotoxicity
- Checked Oct 23, 2026
St John's wortLabel or NIHAn NIH page names this pair (platelets and bleeding).
moderate · Named by an FDA label or NIH page · Platelets and bleeding
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“As a result, St. John’s wort has major drug interactions, particularly with birth control pills, transplant rejection agents, antiretroviral agents, digoxin, platelet inhibitors, anticoagulants and psychotropic agents.”
- LiverTox (NIH) · St. John's Wort. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury (NIDDK), Background
- Checked Oct 23, 2026
Vitamin ELabel or NIHAn NIH page names this pair (platelets and bleeding).
moderate · Named by an FDA label or NIH page · Platelets and bleeding
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Vitamin E supplements can interact with certain medications, including anticoagulants, antiplatelets, simvastatin, and niacin.”
“As a result, taking large doses of vitamin E with anticoagulant or antiplatelet medications, such as warfarin (Coumadin), can increase the risk of bleeding, especially in conjunction with low vitamin K intake.”
- NIH Office of Dietary Supplements · Office of Dietary Supplements · Vitamin E, Interactions with Medications · Anticoagulant and antiplatelet medications
- Checked Oct 25, 2026
Asian ginsengPredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- FDA drug label (DailyMed) · Clopidogrel: affects clotting or platelets (PLAVIX (CLOPIDOGREL) TABLET, FILM COATED [SANOFI-AVENTIS U.S. LLC], section 5.2)
- NIH National Center for Complementary and Integrative Health · Asian ginseng: affects clotting or platelets (Asian Ginseng: Usefulness and Safety, What Do We Know About Safety?)
- Checked Oct 25, 2026
Fish oil (omega-3)PredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- NIH Office of Dietary Supplements · Fish oil (omega-3): affects clotting or platelets (Office of Dietary Supplements · Omega-3 Fatty Acids: Fact Sheet for Health Professionals, Interactions with Medications > Warfarin (Coumadin) and similar anticoagulants)
- FDA drug label (DailyMed) · Clopidogrel: affects clotting or platelets (PLAVIX (CLOPIDOGREL) TABLET, FILM COATED [SANOFI-AVENTIS U.S. LLC], section 5.2)
- Checked Oct 23, 2026
GarlicPredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- FDA drug label (DailyMed) · Clopidogrel: affects clotting or platelets (PLAVIX (CLOPIDOGREL) TABLET, FILM COATED [SANOFI-AVENTIS U.S. LLC], section 5.2)
- NIH National Center for Complementary and Integrative Health · Garlic: affects clotting or platelets (Garlic: Usefulness and Safety, What Do We Know About Safety?)
- Checked Oct 23, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Clopidogrel with everything else you take, together
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- Interaction MapCheck several medicines and supplements at once, each interaction sourced to PubMed, FDA labels or NIH; a pair we have no source for reads as not on our list, never as safe.
- St. John's wortSt.