Amlodipine and supplements: 2 sourced interactions
Calcium channel blocker, also sold as Norvasc. Of these, 2 named by an FDA label or NIH page. Plus 2 predicted from how each works (not established). Plus 1 food and drink line. Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Amlodipine with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
2AshwagandhaLabel or NIHAn NIH page names this pair (cause not established).
moderate · Named by an FDA label or NIH page · Cause not established
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“There is evidence that ashwagandha might interact with some medications, including those for diabetes and high blood pressure, medicines that decrease the immune system response (immunosuppressants), sedatives, anti-seizure medications (anticonvulsants), and thyroid hormone medications.”
- NIH National Center for Complementary and Integrative Health · Ashwagandha: Usefulness and Safety, What Do We Know About Safety?
- Checked Oct 23, 2026
MagnesiumLabel or NIHThe FDA label names this pair (absorption in the gut).
moderate · Named by an FDA label or NIH page · Absorption in the gut
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Co-administered cimetidine, magnesium-and aluminum hydroxide antacids, sildenafil, and grapefruit juice have no impact on the exposure to amlodipine.”
- FDA drug label (DailyMed) · NORVASC (AMLODIPINE BESYLATE) TABLET [VIATRIS SPECIALTY LLC], section 12.3
- Checked Oct 25, 2026
Minor
2Potassium (supplements / salt substitutes)PredictedBoth lower blood pressure, which may add up.
minor · Predicted from how each works, not established · Blood pressure lowering
Predicted from what each is known to do, not studied as a pair and not established.
Both lower blood pressure, which may add up.
- FDA drug label (DailyMed) · Amlodipine: lowers blood pressure (NORVASC (AMLODIPINE BESYLATE) TABLET [VIATRIS SPECIALTY LLC], section 1.1)
- NIH Office of Dietary Supplements · Potassium (supplements / salt substitutes): lowers blood pressure (Office of Dietary Supplements · Potassium, Potassium and Health · Hypertension and stroke)
- Checked Oct 25, 2026
Red yeast ricePredictedBoth lower blood pressure, which may add up.
minor · Predicted from how each works, not established · Blood pressure lowering
Predicted from what each is known to do, not studied as a pair and not established.
Both lower blood pressure, which may add up.
- FDA drug label (DailyMed) · Amlodipine: lowers blood pressure (NORVASC (AMLODIPINE BESYLATE) TABLET [VIATRIS SPECIALTY LLC], section 1.1)
- NIH National Center for Complementary and Integrative Health · Red yeast rice: lowers blood pressure (Red Yeast Rice: What You Need To Know, Are red yeast rice products effective?)
- Checked Oct 25, 2026
Amlodipine with food and drink
Food and drink
1GrapefruitLabel or NIHThe FDA label names this pair (absorption in the gut).
moderate · Named by an FDA label or NIH page · Absorption in the gut
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Co-administered cimetidine, magnesium-and aluminum hydroxide antacids, sildenafil, and grapefruit juice have no impact on the exposure to amlodipine.”
- FDA drug label (DailyMed) · NORVASC (AMLODIPINE BESYLATE) TABLET [VIATRIS SPECIALTY LLC], section 12.3
- Checked Oct 25, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Amlodipine with everything else you take, together
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