Amiodarone and supplements: 1 sourced interaction
Antiarrhythmic, also sold as Pacerone, Cordarone and Nexterone. Of these, 1 named by an FDA label or NIH page. Plus 1 food and drink line. Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Amiodarone with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
1St John's wortLabel or NIHThe FDA label names this pair (cause not established).
moderate · Named by an FDA label or NIH page · Cause not established
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Reduced amiodarone serum levels.”
- FDA drug label (DailyMed) · PACERONE (AMIODARONE HYDROCHLORIDE) TABLET [UPSHER-SMITH LABORATORIES, LLC], section 7
- Checked Oct 25, 2026
Amiodarone with food and drink
Food and drink
1GrapefruitLabel or NIHThe FDA label names this pair (breakdown by liver enzymes).
major · Named by an FDA label or NIH page · Breakdown by liver enzymes
In the source’s own words; rated major from that wording, not from a study of the pair.
“Increased exposure of amiodarone.”
“Grapefruit juice: Grapefruit juice given to healthy volunteers increased amiodarone AUC by 50% and C maxby 84%, and decreased DEA to unquantifiable concentrations.”
- FDA drug label (DailyMed) · PACERONE (AMIODARONE HYDROCHLORIDE) TABLET [UPSHER-SMITH LABORATORIES, LLC], section 12.3
- Checked Oct 25, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Amiodarone with everything else you take, together
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- Interaction MapCheck several medicines and supplements at once, each interaction sourced to PubMed, FDA labels or NIH; a pair we have no source for reads as not on our list, never as safe.
- St. John's wortSt.