Vitamin K2 (MK-7 vs MK-4) and heart

What 2 graded rows on vitamin k2 (mk-7 vs mk-4) agree on for heart, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Vitamin K2 (MK-7 vs MK-4) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Vitamin K2 (MK-7 vs MK-4) page, with its PubMed record.

Supplement

Vitamin K2 (MK-7 vs MK-4) Choose another

2 rows · 1,777 people

They agree: both rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade C, is a meta-analysis of 1,533 people (2023) and found an improvement.

The rows run from 244 to 1,533 people, published from 2015 to 2023: 1 pooled review and 1 single study.

2 improved

Grade CCoronary artery calcium score progression (any vitamin K form) · Improved
Meta-analysis · n 1,533 · 2023 · 14 RCTs in adults (populations not broken down in the abstract)
Varied across trials · Varied across trials
Coronary artery calcium scores progressed less with vitamin K (MD -17.37; p = 0.04) and dp-ucMGP fell; adverse events did not differ from control.
Row on the Vitamin K2 (MK-7 vs MK-4) page · PubMed 37252246 (opens PubMed)
Grade CArterial stiffness with MK-7 · Improved
RCT · n 244 · 2015 · Healthy postmenopausal women (same cohort as the 3-year bone trial)
180 mcg/day · 3 years
Carotid-femoral pulse wave velocity and stiffness index β decreased versus placebo; more local stiffness measures improved in women with higher baseline stiffness. dp-ucMGP fell 50% versus placebo; inflammation and endothelial markers did not change.
Row on the Vitamin K2 (MK-7 vs MK-4) page · PubMed 25694037 (opens PubMed)