Vitamin K2 (MK-7 vs MK-4) and arterial calcification

What 3 graded rows on vitamin k2 (mk-7 vs mk-4) agree on for arterial calcification, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Vitamin K2 (MK-7 vs MK-4) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Vitamin K2 (MK-7 vs MK-4) page, with its PubMed record.

Your question

Bone density3 Arterial calcification3 Bones & joints2 Heart2

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Vitamin K2 (MK-7 vs MK-4) Choose another

Vitamin K2 (MK-7 vs MK-4) and arterial calcification

3 rows · 592 people

Mostly no difference: 2 of 3 rows, and most of the people. 1 found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

Grade C× 1
Grade D× 1
No effect× 1

Rows: 3
Trials: 3
People: 592

Where they differ

From the rows

Who was studiedWhen publishedGrade

The best-graded row, grade C, is a randomized trial of 167 people (2026) and found an improvement. 1 row is graded No effect, our grade for adequately powered trials that found no effect.

Only the 2 rows that found no difference name men and older adults in their population.

The row that found an improvement is newer (2026) than the 2 rows that found no difference (2019 to 2022).

The best grade is C among the row that found an improvement, and D among the rows that found no difference.

The rows

1 improved · 2 no difference

Grade DFemoral artery calcification in type 2 diabetes with MK-7 · No difference
RCT · n 60 · 2019 · Adults with type 2 diabetes and cardiovascular disease (the Netherlands; 68 randomised)
360 mcg/day · 6 months
Calcification on CT did not change versus placebo; active calcification on PET scans tended to increase with MK-7 (P = 0.06, not significant). dp-ucMGP fell. No adverse events.
Row on the Vitamin K2 (MK-7 vs MK-4) page · PubMed 31387121 (opens PubMed)
No effectAortic valve calcification with MK-7 plus vitamin D · No difference
RCT · n 365 · 2022 · Older men with aortic valve calcification (AVADEC, Denmark)
720 mcg/day MK-7 plus 25 mcg vitamin D · 24 months
Valve calcification rose by 275 vs 292 units (difference not significant, P = 0.64); valve area, jet velocity, aortic and coronary calcification, valve surgery, deaths and cardiovascular events did not differ. dp-ucMGP fell with treatment.
Row on the Vitamin K2 (MK-7 vs MK-4) page · PubMed 35465686 (opens PubMed)
Grade CCoronary artery calcium progression with MK-7 in coronary artery disease · Improved
RCT · n 167 · 2026 · Adults with symptomatic coronary artery disease and a calcium score of 50 to 400 (VitaK-CAC, the Netherlands; 180 randomised)
360 mcg/day · 2 years
Calcium scores rose from a median of 145 to 214 on placebo and from 135 to 184 on MK-7 (between-group P = .02); calcium mass showed the same pattern. No significant adverse effects.
Row on the Vitamin K2 (MK-7 vs MK-4) page · PubMed 42268593 (opens PubMed)

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