Zolpidem and supplements: 3 sourced interactions
Sleep medicine (Z-drug), also sold as Ambien, Ambien CR, Edluar and Intermezzo. Of these, 3 named by an FDA label or NIH page. Plus 2 predicted from how each works (not established). Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Zolpidem with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
3AshwagandhaLabel or NIHAn NIH page names this pair (cause not established).
moderate · Named by an FDA label or NIH page · Cause not established
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“There is evidence that ashwagandha might interact with some medications, including those for diabetes and high blood pressure, medicines that decrease the immune system response (immunosuppressants), sedatives, anti-seizure medications (anticonvulsants), and thyroid hormone medications.”
- NIH National Center for Complementary and Integrative Health · Ashwagandha: Usefulness and Safety, What Do We Know About Safety?
- Checked Oct 23, 2026
KavaLabel or NIHAn NIH page names this pair (drowsiness).
moderate · Named by an FDA label or NIH page · Drowsiness
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Kava should not be used together with other substances that have sedative effects, such as benzodiazepines or alcohol.”
- NIH National Center for Complementary and Integrative Health · Kava: Usefulness and Safety, What Do We Know About Safety?
- Checked Oct 25, 2026
St John's wortLabel or NIHThe FDA label names this pair (breakdown by liver enzymes).
moderate · Named by an FDA label or NIH page · Breakdown by liver enzymes
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Use of St. John's wort, a CYP3A4 inducer, in combination with zolpidem may decrease blood levels of zolpidem and is not recommended.”
- FDA drug label (DailyMed) · AMBIEN (ZOLPIDEM TARTRATE) TABLET, FILM COATED [SANOFI-AVENTIS U.S. LLC], section 7.2
- Checked Oct 25, 2026
Minor
2Cannabidiol (CBD)PredictedBoth can cause drowsiness, which may add up.
minor · Predicted from how each works, not established · Drowsiness
Predicted from what each is known to do, not studied as a pair and not established.
Both can cause drowsiness, which may add up.
- FDA drug label (DailyMed) · Zolpidem: can cause drowsiness (AMBIEN (ZOLPIDEM TARTRATE) TABLET, FILM COATED [SANOFI-AVENTIS U.S. LLC], section 5.2)
- NIH National Center for Complementary and Integrative Health · Cannabidiol (CBD): can cause drowsiness (Cannabis (Marijuana) and Cannabinoids: What You Need To Know, Can CBD be harmful?)
- Checked Oct 25, 2026
MelatoninPredictedBoth can cause drowsiness, which may add up.
minor · Predicted from how each works, not established · Drowsiness
Predicted from what each is known to do, not studied as a pair and not established.
Both can cause drowsiness, which may add up.
- NIH National Center for Complementary and Integrative Health · Melatonin: can cause drowsiness (Melatonin: What You Need To Know, Is it safe to take melatonin? > Safety concerns for older people)
- FDA drug label (DailyMed) · Zolpidem: can cause drowsiness (AMBIEN (ZOLPIDEM TARTRATE) TABLET, FILM COATED [SANOFI-AVENTIS U.S. LLC], section 5.2)
- Checked Oct 25, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Zolpidem with everything else you take, together
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- Next in this topicInteractions by medicineEach medicine’s sourced supplement interactions by severity: studied, label or NIH, predicted.
- Interaction MapCheck several medicines and supplements at once, each interaction sourced to PubMed, FDA labels or NIH; a pair we have no source for reads as not on our list, never as safe.
- St. John's wortSt.