Trazodone and supplements: 2 sourced interactions
Antidepressant (SARI), also sold as Desyrel and Oleptro. Of these, 2 named by an FDA label or NIH page. Plus 10 predicted from how each works (not established). Plus 1 food and drink line. Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Trazodone with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
7SAMeLabel or NIHAn NIH page names this pair (serotonin activity).
moderate · Named by an FDA label or NIH page · Serotonin activity
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“It’s also possible that SAMe might interact with drugs and dietary supplements that increase levels of serotonin (a chemical produced by nerve cells), such as antidepressants, L-tryptophan, and St. John’s wort.”
- NIH National Center for Complementary and Integrative Health · S-Adenosyl-L-Methionine (SAMe): In Depth, Safety and Side Effects of SAMe
- Checked Oct 25, 2026
St John's wortLabel or NIHThe FDA label names this pair (serotonin activity).
moderate · Named by an FDA label or NIH page · Serotonin activity
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John’s Wort) and with drugs that impair metabolism of serotonin, i.e., MAOIs [see Contraindications (4), Drug Interactions (7.1)].”
“The concomitant use of serotonergic drugs including trazodone hydrochloride tablets and other serotonergic drugs increases the risk of serotonin syndrome.”
“The concomitant use of trazodone hydrochloride tablets and strong CYP3A4 inducers decreased the exposure of trazodone compared to the use of trazodone hydrochloride tablets alone.”
- FDA drug label (DailyMed) · TRAZODONE HYDROCHLORIDE TABLET [TEVA PHARMACEUTICALS USA, INC.], section 7.1
- Checked Oct 25, 2026
Asian ginsengPredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- FDA drug label (DailyMed) · Trazodone: affects clotting or platelets (TRAZODONE HYDROCHLORIDE TABLET [TEVA PHARMACEUTICALS USA, INC.], section 5.5)
- NIH National Center for Complementary and Integrative Health · Asian ginseng: affects clotting or platelets (Asian Ginseng: Usefulness and Safety, What Do We Know About Safety?)
- Checked Oct 25, 2026
Fish oil (omega-3)PredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- NIH Office of Dietary Supplements · Fish oil (omega-3): affects clotting or platelets (Office of Dietary Supplements · Omega-3 Fatty Acids: Fact Sheet for Health Professionals, Interactions with Medications > Warfarin (Coumadin) and similar anticoagulants)
- FDA drug label (DailyMed) · Trazodone: affects clotting or platelets (TRAZODONE HYDROCHLORIDE TABLET [TEVA PHARMACEUTICALS USA, INC.], section 5.5)
- Checked Oct 25, 2026
GarlicPredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- NIH National Center for Complementary and Integrative Health · Garlic: affects clotting or platelets (Garlic: Usefulness and Safety, What Do We Know About Safety?)
- FDA drug label (DailyMed) · Trazodone: affects clotting or platelets (TRAZODONE HYDROCHLORIDE TABLET [TEVA PHARMACEUTICALS USA, INC.], section 5.5)
- Checked Oct 25, 2026
Ginkgo bilobaPredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- NIH National Center for Complementary and Integrative Health · Ginkgo biloba: affects clotting or platelets (Ginkgo: Usefulness and Safety, What Do We Know About Safety?)
- FDA drug label (DailyMed) · Trazodone: affects clotting or platelets (TRAZODONE HYDROCHLORIDE TABLET [TEVA PHARMACEUTICALS USA, INC.], section 5.5)
- Checked Oct 25, 2026
Vitamin EPredictedBoth can affect clotting or platelets, so bleeding risk may add up.
moderate · Predicted from how each works, not established · Platelets and bleeding
Predicted from what each is known to do, not studied as a pair and not established.
Both can affect clotting or platelets, so bleeding risk may add up.
- FDA drug label (DailyMed) · Trazodone: affects clotting or platelets (TRAZODONE HYDROCHLORIDE TABLET [TEVA PHARMACEUTICALS USA, INC.], section 5.5)
- NIH Office of Dietary Supplements · Vitamin E: affects clotting or platelets (Office of Dietary Supplements · Vitamin E, Interactions with Medications · Anticoagulant and antiplatelet medications)
- Checked Oct 25, 2026
Minor
5AshwagandhaPredictedBoth can cause drowsiness, which may add up.
minor · Predicted from how each works, not established · Drowsiness
Predicted from what each is known to do, not studied as a pair and not established.
Both can cause drowsiness, which may add up.
- NIH National Center for Complementary and Integrative Health · Ashwagandha: can cause drowsiness (Ashwagandha: Usefulness and Safety, What Do We Know About Safety?)
- FDA drug label (DailyMed) · Trazodone: can cause drowsiness (TRAZODONE HYDROCHLORIDE TABLET [TEVA PHARMACEUTICALS USA, INC.], section 5.9)
- Checked Oct 25, 2026
Cannabidiol (CBD)PredictedBoth can cause drowsiness, which may add up.
minor · Predicted from how each works, not established · Drowsiness
Predicted from what each is known to do, not studied as a pair and not established.
Both can cause drowsiness, which may add up.
- FDA drug label (DailyMed) · Trazodone: can cause drowsiness (TRAZODONE HYDROCHLORIDE TABLET [TEVA PHARMACEUTICALS USA, INC.], section 5.9)
- NIH National Center for Complementary and Integrative Health · Cannabidiol (CBD): can cause drowsiness (Cannabis (Marijuana) and Cannabinoids: What You Need To Know, Can CBD be harmful?)
- Checked Oct 25, 2026
MelatoninPredictedBoth can cause drowsiness, which may add up.
minor · Predicted from how each works, not established · Drowsiness
Predicted from what each is known to do, not studied as a pair and not established.
Both can cause drowsiness, which may add up.
- NIH National Center for Complementary and Integrative Health · Melatonin: can cause drowsiness (Melatonin: What You Need To Know, Is it safe to take melatonin? > Safety concerns for older people)
- FDA drug label (DailyMed) · Trazodone: can cause drowsiness (TRAZODONE HYDROCHLORIDE TABLET [TEVA PHARMACEUTICALS USA, INC.], section 5.9)
- Checked Oct 25, 2026
Potassium (supplements / salt substitutes)PredictedBoth lower blood pressure, which may add up.
minor · Predicted from how each works, not established · Blood pressure lowering
Predicted from what each is known to do, not studied as a pair and not established.
Both lower blood pressure, which may add up.
- FDA drug label (DailyMed) · Trazodone: lowers blood pressure (TRAZODONE HYDROCHLORIDE TABLET [TEVA PHARMACEUTICALS USA, INC.], section 5.4)
- NIH Office of Dietary Supplements · Potassium (supplements / salt substitutes): lowers blood pressure (Office of Dietary Supplements · Potassium, Potassium and Health · Hypertension and stroke)
- Checked Oct 25, 2026
Red yeast ricePredictedBoth lower blood pressure, which may add up.
minor · Predicted from how each works, not established · Blood pressure lowering
Predicted from what each is known to do, not studied as a pair and not established.
Both lower blood pressure, which may add up.
- FDA drug label (DailyMed) · Trazodone: lowers blood pressure (TRAZODONE HYDROCHLORIDE TABLET [TEVA PHARMACEUTICALS USA, INC.], section 5.4)
- NIH National Center for Complementary and Integrative Health · Red yeast rice: lowers blood pressure (Red Yeast Rice: What You Need To Know, Are red yeast rice products effective?)
- Checked Oct 25, 2026
Trazodone with food and drink
Food and drink
1GrapefruitPredictedGrapefruit may raise Trazodone levels: it slows CYP3A, an enzyme that breaks Trazodone down.
moderate · Predicted from how each works, not established · Breakdown by liver enzymes
Predicted from what each is known to do, not studied as a pair and not established.
Grapefruit may raise Trazodone levels: it slows CYP3A, an enzyme that breaks Trazodone down.
- FDA table of drugs that interact with CYP enzymes · Grapefruit: CYP3A moderate inhibitor (Table 1, row "grapefruit juice", column "CYP Mod INH" (footnote 9: The effect of grapefruit juice varies widely among brands and is concentration-, dose-, and preparation-dependent. Studies have shown that it can be classified as a “strong CYP3A inhibitor” when a certain preparation was used (e.g., high dose, double strength) or more commonly as a “moderate CYP3A inhibitor” when another preparation was used (e.g., low dose, single strength).))
- FDA drug label (DailyMed) · Trazodone: CYP3A substrate (TRAZODONE HYDROCHLORIDE TABLET [TEVA PHARMACEUTICALS USA, INC.], section 12.3)
- Checked Oct 25, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Trazodone with everything else you take, together
Keep reading: Supplements and vitamins
Supplements and vitamins: every pageSupplement & Nutrient EncyclopediaBrowse all topics
- Previous in this topicTramadol and supplements: 3 sourced interactionsTramadol (Ultram, ConZip) with supplements, by severity, each line studied in people or named by an FDA label or NIH page, with its source.
- Next in this topicVenlafaxine and supplements: 2 sourced interactionsVenlafaxine (Effexor XR, Effexor) with supplements, by severity, each line studied in people or named by an FDA label or NIH page, with its source.
- St. John's wortSt.
- Interaction MapCheck several medicines and supplements at once, each interaction sourced to PubMed, FDA labels or NIH; a pair we have no source for reads as not on our list, never as safe.