Pantoprazole and supplements: 2 sourced interactions
Proton pump inhibitor, also sold as Protonix. Of these, 2 named by an FDA label or NIH page. Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 23, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Pantoprazole with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
2IronLabel or NIHThe FDA label names this pair (absorption in the gut).
moderate · Named by an FDA label or NIH page · Absorption in the gut
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole/itraconazole)”
“Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole/itraconazole) Clinical Impact: Pantoprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity.”
“Because proton pump inhibitors, such as lansoprazole (Prevacid) and omeprazole (Prilosec), reduce the acidity of stomach contents, they can reduce iron absorption”
- FDA drug label (DailyMed) · PROTONIX (pantoprazole sodium) delayed-release tablets and for delayed-release oral suspension, Rx, section 7
- NIH Office of Dietary Supplements · Office of Dietary Supplements · Iron: Fact Sheet for Health Professionals, Interactions with Medications > Proton pump inhibitors
- Checked Oct 23, 2026
MagnesiumLabel or NIHAn NIH page names this pair (cause not established).
moderate · Named by an FDA label or NIH page · Cause not established
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Prescription proton pump inhibitor (PPI) drugs, such as esomeprazole magnesium (Nexium) and lansoprazole (Prevacid), can cause hypomagnesemia when taken for prolonged periods (typically more than a year)”
- NIH Office of Dietary Supplements · Office of Dietary Supplements · Magnesium: Fact Sheet for Health Professionals, Interactions with Medications > Proton pump inhibitors
- Checked Oct 23, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Pantoprazole with everything else you take, together
Keep reading: Supplements and vitamins
Supplements and vitamins: every pageSupplement & Nutrient EncyclopediaBrowse all topics
- Previous in this topicOmeprazole and supplements: 3 sourced interactionsOmeprazole (Prilosec, Prilosec OTC, Zegerid) with supplements, by severity, each line studied in people or named by an FDA label or NIH page, with its source.
- Next in this topicParoxetine and supplements: 4 sourced interactionsParoxetine (Paxil, Pexeva) with supplements, by severity, each line studied in people or named by an FDA label or NIH page, with its source.
- St. John's wortSt.
- Interaction MapCheck several medicines and supplements at once, each interaction sourced to PubMed, FDA labels or NIH; a pair we have no source for reads as not on our list, never as safe.