Losartan and supplements: 3 sourced interactions
ARB (blood pressure), also sold as Cozaar. Of these, 3 named by an FDA label or NIH page. Plus 1 predicted from how each works (not established). Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Losartan with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
3AshwagandhaLabel or NIHAn NIH page names this pair (cause not established).
moderate · Named by an FDA label or NIH page · Cause not established
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“There is evidence that ashwagandha might interact with some medications, including those for diabetes and high blood pressure, medicines that decrease the immune system response (immunosuppressants), sedatives, anti-seizure medications (anticonvulsants), and thyroid hormone medications.”
- NIH National Center for Complementary and Integrative Health · Ashwagandha: Usefulness and Safety, What Do We Know About Safety?
- Checked Oct 23, 2026
BerberineLabel or NIHAn NIH page names this pair (breakdown by liver enzymes).
moderate · Named by an FDA label or NIH page · Breakdown by liver enzymes
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Repeated administration of berberine (300 mg, t.i.d., p.o.) decreased CYP2D6, 2C9, and CYP3A4 activities.”
- PubMed · Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012, Abstract: Conclusions
- Checked Oct 23, 2026
Potassium (supplements / salt substitutes)Label or NIHAn NIH page names this pair (potassium level).
moderate · Named by an FDA label or NIH page · Potassium level
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Experts recommend monitoring potassium status in people taking ACE inhibitors or ARBs, especially if they have other risk factors for hyperkalemia, such as impaired kidney function [75].”
- NIH Office of Dietary Supplements · Office of Dietary Supplements · Potassium, Interactions with Medications · Angiotensin converting enzyme inhibitors and angiotensin receptor blockers
- Checked Oct 25, 2026
Minor
1Red yeast ricePredictedBoth lower blood pressure, which may add up.
minor · Predicted from how each works, not established · Blood pressure lowering
Predicted from what each is known to do, not studied as a pair and not established.
Both lower blood pressure, which may add up.
- FDA drug label (DailyMed) · Losartan: lowers blood pressure (COZAAR (LOSARTAN POTASSIUM) TABLET, FILM COATED [ORGANON LLC], section 1.1)
- NIH National Center for Complementary and Integrative Health · Red yeast rice: lowers blood pressure (Red Yeast Rice: What You Need To Know, Are red yeast rice products effective?)
- Checked Oct 25, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Losartan with everything else you take, together
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