Hydrochlorothiazide and supplements: 4 sourced interactions
Thiazide diuretic, also sold as Microzide. Of these, 4 named by an FDA label or NIH page. Plus 1 predicted from how each works (not established). Each links its source and the date it was checked.
From the Interaction Map Sources checked Oct 25, 2026
A combination missing here is not on our list; that does not mean it is safe together.
Hydrochlorothiazide with supplements
Most serious first. Open a row for the mechanism, the source's words and the date checked.
Educational only. Check with your pharmacist or prescriber before changing anything you take.
Moderate
4AshwagandhaLabel or NIHAn NIH page names this pair (cause not established).
moderate · Named by an FDA label or NIH page · Cause not established
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“There is evidence that ashwagandha might interact with some medications, including those for diabetes and high blood pressure, medicines that decrease the immune system response (immunosuppressants), sedatives, anti-seizure medications (anticonvulsants), and thyroid hormone medications.”
- NIH National Center for Complementary and Integrative Health · Ashwagandha: Usefulness and Safety, What Do We Know About Safety?
- Checked Oct 23, 2026
MagnesiumLabel or NIHAn NIH page names this pair (cause not established).
moderate · Named by an FDA label or NIH page · Cause not established
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Chronic treatment with loop diuretics, such as furosemide (Lasix) and bumetanide (Bumex), and thiazide diuretics, such as hydrochlorothiazide (Aquazide H) and ethacrynic acid (Edecrin), can increase the loss of magnesium in urine and lead to magnesium depletion”
- NIH Office of Dietary Supplements · Office of Dietary Supplements · Magnesium: Fact Sheet for Health Professionals, Interactions with Medications > Diuretics
- Checked Oct 23, 2026
Potassium (supplements / salt substitutes)Label or NIHThe FDA label names this pair (potassium level).
moderate · Named by an FDA label or NIH page · Potassium level
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Hypokalemia may be avoided or treated by use of potassium sparing diuretics or potassium supplements such as foods with a high potassium content.”
“Treatment with loop diuretics, such as furosemide (Lasix) and bumetanide (Bumex), and thiazide diuretics, such as chlorothiazide (Diuril) and metolazone (Zaroxolyn), increases urinary potassium excretion and can lead to hypokalemia [77,78].”
- FDA drug label (DailyMed) · HYDROCHLOROTHIAZIDE TABLET [ACCORD HEALTHCARE INC.], PRECAUTIONS · General
- NIH Office of Dietary Supplements · Office of Dietary Supplements · Potassium, Interactions with Medications · Loop and thiazide diuretics
- Checked Oct 25, 2026
ZincLabel or NIHAn NIH page names this pair (cause not established).
moderate · Named by an FDA label or NIH page · Cause not established
In the source’s own words; rated moderate from that wording, not from a study of the pair.
“Thiazide diuretics, such as chlorthalidone (e.g., Hygroton, Thalitone) and hydrochlorothiazide (e.g., Esidrix, HydroDIURIL), increase zinc excretion in the urine.”
- NIH Office of Dietary Supplements · Office of Dietary Supplements · Zinc: Fact Sheet for Health Professionals, Interactions with Medications > Diuretics
- Checked Oct 23, 2026
Minor
1Red yeast ricePredictedBoth lower blood pressure, which may add up.
minor · Predicted from how each works, not established · Blood pressure lowering
Predicted from what each is known to do, not studied as a pair and not established.
Both lower blood pressure, which may add up.
- FDA drug label (DailyMed) · Hydrochlorothiazide: lowers blood pressure (HYDROCHLOROTHIAZIDE TABLET [ACCORD HEALTHCARE INC.], INDICATIONS AND USAGE)
- NIH National Center for Complementary and Integrative Health · Red yeast rice: lowers blood pressure (Red Yeast Rice: What You Need To Know, Are red yeast rice products effective?)
- Checked Oct 25, 2026
How these lines are sourced
Three kinds of line
- Studied in people (PubMed): PubMed records that were opened and read, graded A (several controlled studies, or a finding in the dosing guidance), B (at least one controlled human study) or C (case reports, observational data or mechanism only).
- Named by an FDA label or NIH page: quoted word for word from that page. Its severity comes from the source’s wording, not from a study of the pair.
- Predicted from how each works, not established: built from sourced facts about each substance, such as the FDA’s table of enzyme roles. Never rated major.
Interaction MapCheck Hydrochlorothiazide with everything else you take, together
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- Interaction MapCheck several medicines and supplements at once, each interaction sourced to PubMed, FDA labels or NIH; a pair we have no source for reads as not on our list, never as safe.