L. rhamnosus GR-1 and L. reuteri RC-14 and urinary infections

What 2 graded rows on l. rhamnosus gr-1 and l. reuteri rc-14 agree on for urinary infections, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the L. rhamnosus GR-1 and L. reuteri RC-14 page, with its PubMed record.

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L. rhamnosus GR-1 and L. reuteri RC-14 and urinary infections

2 rows · 459 people

Split. 1 row found no difference and 1 had mixed results.

No difference or mixed
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.
  • Grade C× 1
  • No effect× 1
Rows
2
Trials
2
People
459

What the rows share

From the rows

The best-graded row, grade C, is a randomized trial of 252 people (2012) and reported mixed results. 1 row is graded No effect, our grade for adequately powered trials that found no effect.

The rows run from 207 to 252 people, published from 2012 to 2019: 2 single studies.

The rows

1 no difference · 1 mixed
  1. No effectUrinary tract infections after spinal cord injury · No difference

    RCT · n 207 · 2019 · 207 people with spinal cord injury and neurogenic bladder in Australia

    Daily (dose not stated in the abstract) · 6 months

    Risk of symptomatic UTI did not differ with RC14-GR1 (HR 0.67; 95% CI 0.39 to 1.18; P = 0.17); a post hoc analysis hinted at benefit but needs confirmation.

    Row on the L. rhamnosus GR-1 and L. reuteri RC-14 page · PubMed 30814670 (opens PubMed)

  2. Grade CRecurrent urinary tract infections vs antibiotic prophylaxis · Mixed

    RCT · n 252 · 2012 · 252 postmenopausal women with recurrent UTIs

    1 billion CFU twice daily · 12 months

    UTIs fell from 6.8 to 3.3 a year on lactobacilli and from 7.0 to 2.9 on the antibiotic; the 0.4 UTI difference missed the non-inferiority margin. Antibiotic resistance in E. coli rose on the antibiotic but did not rise on lactobacilli.

    Row on the L. rhamnosus GR-1 and L. reuteri RC-14 page · PubMed 22782199 (opens PubMed)

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