L. rhamnosus GR-1 and L. reuteri RC-14 and pregnancy
What 3 graded rows on l. rhamnosus gr-1 and l. reuteri rc-14 agree on for pregnancy, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the L. rhamnosus GR-1 and L. reuteri RC-14 page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the L. rhamnosus GR-1 and L. reuteri RC-14 page, with its PubMed record.
Your question
L. rhamnosus GR-1 and L. reuteri RC-14 and pregnancy
3 rows · 553 peopleMostly no difference: 2 of 3 rows, and most of the people. 1 found an improvement.
- CGrade C× 1
- ∅No effect× 2
- Rows
- 3
- Trials
- 3
- People
- 553
Where they differ
From the rowsThe best-graded row, grade C, is a randomized trial of 110 people (2016) and found an improvement. 2 rows are graded No effect, our grade for adequately powered trials that found no effect.
The 2 rows that found no difference were larger: a median of 222 people, against 110 people for the row that found an improvement.
The 2 rows that found no difference are newer (2020 to 2021) than the row that found an improvement (2016).
The rows
1 improved · 2 no difference- ∅No effectBacterial vaginosis in early pregnancy · No difference
RCT · n 304 · 2020 · 304 pregnant women recruited at 9 to 14 weeks in the UK; 238 analysed
2.5 billion CFU of each strain once daily · Recruitment to end of pregnancy
Bacterial vaginosis at 18 to 20 weeks did not differ: 15% on probiotic vs 9% on placebo (adjusted odds ratio 1.82, 95% CI 0.64 to 5.19); no change in colonisation or vaginal microbiome.
Row on the L. rhamnosus GR-1 and L. reuteri RC-14 page · PubMed 30932317 (opens PubMed)
- ∅No effectGroup B strep colonisation in pregnancy (pilot) · No difference
Pilot RCT · n 139 · 2021 · 139 pregnant midwifery clients in Toronto; 113 analysed
2 capsules daily from 23 to 25 weeks · 12 weeks
GBS colonisation at 35 to 37 weeks did not differ: 15.8% vs 21.43% (p = .48); the trial's main aim was feasibility.
Row on the L. rhamnosus GR-1 and L. reuteri RC-14 page · PubMed 31362572 (opens PubMed)
- CGrade CGroup B strep colonisation late in pregnancy · Improved
RCT · n 110 · 2016 · 110 GBS-positive pregnant women at 35 to 37 weeks in Taiwan; 99 completed
2 capsules at bedtime · Until delivery
GBS changed from positive to negative in 21 women (42.9%) on probiotic vs 9 (18.0%) on placebo (p=0.007).
Row on the L. rhamnosus GR-1 and L. reuteri RC-14 page · PubMed 27590374 (opens PubMed)