Glutathione (oral) and skin

What 2 graded rows on glutathione (oral) agree on for skin, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Glutathione (oral) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Glutathione (oral) page, with its PubMed record.

Supplement

Glutathione (oral) Choose another

2 rows · 184 people

They agree: both rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade C, is a randomized trial of 124 people (2022) and found an improvement.

The rows run from 60 to 124 people, published from 2012 to 2022: 2 single studies.

2 improved

Grade CSkin lightening and dark-spot size · Improved
RCT · n 124 · 2022 · Asian women
250 mg/day glutathione (with or without 500 mg L-cystine) · 12 weeks
The cystine plus glutathione combination lightened skin and shrank dark spots more than placebo and more than either ingredient alone.
Row on the Glutathione (oral) page · PubMed 33834608 (opens PubMed)
Grade CSkin melanin index · Improved
RCT · n 60 · 2012 · Healthy Thai medical students
500 mg/day in two doses · 4 weeks
Melanin index fell at all six sites with glutathione; the difference from placebo was significant at two sites (right face and sun-exposed forearm).
Row on the Glutathione (oral) page · PubMed 20524875 (opens PubMed)