Glutathione (oral) and glutathione levels
What 3 graded rows on glutathione (oral) agree on for glutathione levels, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Glutathione (oral) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Glutathione (oral) page, with its PubMed record.
Your question
Glutathione (oral) and glutathione levels
3 rows · 106 peopleMostly an improvement: 2 of 3 rows, and most of the people. 1 found no difference.
- CGrade C× 2
- DGrade D× 1
- Rows
- 3
- Trials
- 3
- People
- 106
Where they differ
From the rowsThe best-graded row, grade C, is a randomized trial of 54 people (2015) and found an improvement.
The 2 rows that found an improvement are newer (2015 to 2018) than the row that found no difference (2011).
The rows
2 improved · 1 no difference- CGrade CGlutathione levels in blood and cells · Improved
RCT · n 54 · 2015 · Healthy non-smoking adults
250 or 1,000 mg/day · 6 months
Glutathione rose 30–35% in red cells, plasma and lymphocytes and 260% in cheek cells at 1,000 mg/day; smaller rises at 250 mg/day. Levels returned to baseline 1 month after stopping. Oxidized-to-reduced glutathione ratio fell in both groups.
Row on the Glutathione (oral) page · PubMed 24791752 (opens PubMed)
- DGrade DGlutathione levels with liposomal delivery · Improved
Open-label trial · n 12 · 2018 · Healthy adults
500 or 1,000 mg/day · 4 weeks
Whole-blood glutathione rose up to 40% and immune-cell (PBMC) glutathione up to 100% by week 2; NK-cell activity markers also rose.
Row on the Glutathione (oral) page · PubMed 28853742 (opens PubMed)
- CGrade COxidative stress markers and glutathione status · No difference
RCT · n 40 · 2011 · Adults without acute or chronic disease
500 mg twice daily (1,000 mg/day) · 4 weeks
No significant change vs placebo in urinary F2-isoprostanes, 8-OHdG, or red-cell reduced, oxidized or ratio glutathione.
Row on the Glutathione (oral) page · PubMed 21875351 (opens PubMed)