CoQ10 (ubiquinol vs ubiquinone) and statin muscle symptoms
What 2 graded rows on coq10 (ubiquinol vs ubiquinone) agree on for statin muscle symptoms, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the CoQ10 (ubiquinol vs ubiquinone) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the CoQ10 (ubiquinol vs ubiquinone) page, with its PubMed record.
Your question
CoQ10 (ubiquinol vs ubiquinone) and statin muscle symptoms
2 rows · 964 peopleSplit. 1 row found an improvement and 1 had mixed results.
- CGrade C× 2
- Rows
- 2
- Trials
- 19
- People
- 964
- Pooled reviews may count some twice
What the rows share
From the rowsThe best-graded row, grade C, is a meta-analysis of 575 people (2018) and reported mixed results.
The rows run from 389 to 575 people, published from 2018 to 2025: 2 pooled reviews and 0 single studies.
The rows
1 improved · 1 mixed- CGrade CMuscle pain in statin users (2025 meta-analysis) · Improved
Meta-analysis, 7 studies · n 389 · 2025 · Adults on statins with muscle symptoms in 7 randomized trials of 35 to 76 patients each
100 to 600 mg/day · 30 to 90 days
Muscle pain intensity fell more with CoQ10 than with control (weighted mean difference −0.96, 95% CI −1.88 to −0.03); 4 trials found a significant reduction and 3 did not.
Row on the CoQ10 (ubiquinol vs ubiquinone) page · PubMed 41158831 (opens PubMed)
- CGrade CMuscle symptoms in statin users · Mixed
Meta-analysis, 12 studies · n 575 · 2018 · 12 RCTs (575 patients) of CoQ10 for statin-associated muscle symptoms
Varied across trials · Varied across trials
CoQ10 reduced muscle pain, weakness, cramps and tiredness scores versus placebo; creatine kinase did not change.
Row on the CoQ10 (ubiquinol vs ubiquinone) page · PubMed 30371340 (opens PubMed)