Chanca piedra (Phyllanthus niruri, gale of the wind) and liver

What 3 graded rows on chanca piedra (phyllanthus niruri, gale of the wind) agree on for liver, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Chanca piedra (Phyllanthus niruri, gale of the wind) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Chanca piedra (Phyllanthus niruri, gale of the wind) page, with its PubMed record.

Your question

Kidney stones3 Liver3 Hepatitis B2

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Chanca piedra (Phyllanthus niruri, gale of the wind) and liver

3 rows · 425 people

Split. 1 row found no difference and 2 had mixed results.

No difference or mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

Grade B× 1
Grade C× 2

Rows: 3
Trials: 3
People: 425

What the rows share

From the rows

The best-graded row, grade B, is a randomized trial of 226 people (2023) and reported mixed results.

The rows run from 71 to 226 people, published from 2021 to 2025: 3 single studies.

The rows

1 no difference · 2 mixed

Grade CLiver enzymes and fibrosis score with a P. niruri and milk thistle combination · No difference
RCT · n 128 · 2025 · Egyptian adults with risk factors for non-alcoholic steatohepatitis (146 enrolled)
1 or 2 capsules a day (200–400 mg P. niruri) · 36 weeks
ALT fell within both dose groups, but the percentage change in ALT and AST and the Fib-4 score did not differ from placebo. The capsules were well tolerated.
Row on the Chanca piedra (Phyllanthus niruri, gale of the wind) page · PubMed 39789561 (opens PubMed)
Grade BLiver fat, liver enzymes and fibrosis score in fatty liver · Mixed
RCT · n 226 · 2023 · Malaysian adults with mild-to-moderate non-alcoholic fatty liver disease
3,000 mg/day · 12 months
No difference from placebo in liver fat (CAP -15.05 vs -14.74 dB/m) or liver enzymes, the primary outcomes. Fibrosis score fell with the extract (-0.64 vs +0.10 kPa). No major adverse events.
Row on the Chanca piedra (Phyllanthus niruri, gale of the wind) page · PubMed 37313177 (opens PubMed)
Grade CLiver function in alcoholic hepatitis · Mixed
RCT · n 71 · 2021 · Indian adults with mild-to-moderate alcoholic hepatitis
Not stated in the abstract · 4 weeks
Liver and kidney function tests did not improve versus placebo. Total antioxidant levels rose (P = 0.034) and appetite improved (P = 0.03).
Row on the Chanca piedra (Phyllanthus niruri, gale of the wind) page · PubMed 34975132 (opens PubMed)

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