Chanca piedra (Phyllanthus niruri, gale of the wind) and hepatitis B

What 2 graded rows on chanca piedra (phyllanthus niruri, gale of the wind) agree on for hepatitis B, and where they differ. Counted side by side, never averaged.

What the rows agree on

Each block and row is one graded row from the Chanca piedra (Phyllanthus niruri, gale of the wind) page, with its PubMed record.

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Chanca piedra (Phyllanthus niruri, gale of the wind) and hepatitis B

2 rows · 1,373 people

Split. 1 row found no difference and 1 had mixed results.

No difference or mixed
Improved
Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.
  • Grade C× 1
  • Grade D× 1
Rows
2
Trials
17
People
1,373
Pooled reviews may count some twice

What the rows share

From the rows

The best-graded row, grade C, is a meta-analysis of 1,326 people (2011) and reported mixed results.

The rows run from 47 to 1,326 people, published from 2011 to 2018: 1 pooled review and 1 single study.

The rows

1 no difference · 1 mixed
  1. Grade DHepatitis B viral load · No difference

    RCT · n 47 · 2018 · Adults with chronic hepatitis B

    Not stated in the abstract · 12 months

    No difference in viral load versus placebo and no HBsAg clearance; kidney function was unchanged and no serious adverse events occurred. The trial was stopped early for lack of benefit.

    Row on the Chanca piedra (Phyllanthus niruri, gale of the wind) page · PubMed 30372693 (opens PubMed)

  2. Grade CHepatitis B virus markers · Mixed

    Meta-analysis, 16 studies · n 1,326 · 2011 · People with chronic hepatitis B in randomized trials (mostly China)

    Varied by trial · Varied by trial

    Versus placebo (one trial, 42 people) there was no difference in HBeAg seroconversion. Added to antivirals, Phyllanthus improved HBV DNA and HBeAg measures, but with substantial heterogeneity and risk of bias; no serious adverse events were reported.

    Row on the Chanca piedra (Phyllanthus niruri, gale of the wind) page · PubMed 21491412 (opens PubMed)

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