Ceramides (oral phytoceramides) and skin hydration

What 3 graded rows on ceramides (oral phytoceramides) agree on for skin hydration, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Ceramides (oral phytoceramides) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Ceramides (oral phytoceramides) page, with its PubMed record.

Supplement

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3 rows · 174 people

They agree: all 3 rows found an improvement.

No difference

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside.

From the rows

The best-graded row, grade C, is a randomized trial of 72 people (2024) and found an improvement.

The rows run from 51 to 72 people, published from 2011 to 2024: 3 single studies.

3 improved

Grade CDry skin, water loss and wrinkles · Improved
RCT · n 72 · 2024 · Women with dry and wrinkled skin, at least 10 postmenopausal per group
Not stated in the abstract · 56 days, plus 56 days off supplement
Hydration, smoothness and elasticity rose and water loss, roughness and wrinkle depth fell from day 14 versus placebo, including in postmenopausal women; none of the gains lasted after stopping.
Row on the Ceramides (oral phytoceramides) page · PubMed 38100124 (opens PubMed)
Grade CSkin dryness and related signs · Improved
RCT · n 51 · 2020 · Healthy adults aged 18 to 60 (India)
100 mg/day (5 mg glycosylceramides) · 6 weeks
Skin dryness, hyperpigmentation, redness, itching and oiliness decreased significantly versus placebo (p < 0.05) on dermatological assessment; no adverse events.
Row on the Ceramides (oral phytoceramides) page · PubMed 32020853 (opens PubMed)
Grade CSkin hydration in women with dry skin · Improved
RCT · n 51 · 2011 · Women aged 20 to 63 with dry to very dry skin (France)
350 mg/day · 3 months
Skin hydration rose significantly more than with placebo on the arms (p < 0.001) and legs (p = 0.012); dermatologist-scored dryness and redness did not differ significantly, and self-rated hydration only trended better (p = 0.084).
Row on the Ceramides (oral phytoceramides) page · PubMed 20646083 (opens PubMed)