Ceramides (oral phytoceramides) and skin barrier

What 2 graded rows on ceramides (oral phytoceramides) agree on for skin barrier, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Ceramides (oral phytoceramides) page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Ceramides (oral phytoceramides) page, with its PubMed record.

Supplement

Ceramides (oral phytoceramides) Choose another

2 rows · 46 people

Split. 1 row found an improvement and 1 had mixed results.

Mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

From the rows

The best-graded row, grade D, is a randomized trial of 29 people (2024) and reported mixed results.

The rows run from 17 to 29 people, published from 2018 to 2024: 2 single studies.

1 improved · 1 mixed

Grade DSkin water loss and dryness in winter · Improved
Crossover RCT · n 17 · 2018 · Healthy Japanese volunteers in winter
1.8 mg/day · 4 weeks per period
Forearm water loss fell more with glucosylceramide (−1.26 vs −0.97 g/m²·h; p = 0.01); brown spots decreased (p = 0.04) and chapped skin improved (p = 0.04) versus placebo.
Row on the Ceramides (oral phytoceramides) page · PubMed 30175789 (opens PubMed)
Grade DSkin barrier water loss · Mixed
RCT · n 29 · 2024 · Healthy Japanese adults aged 20 to 64
Not stated in the abstract · 12 weeks
Water loss (the primary outcome) was lower than placebo at 12 weeks (p = 0.04) but not at 8 weeks (p = 0.07); hydration, itch and quality-of-life scores did not differ.
Row on the Ceramides (oral phytoceramides) page · PubMed 38999848 (opens PubMed)