Bacillus coagulans (spore-forming probiotic) and IBS
What 3 graded rows on bacillus coagulans (spore-forming probiotic) agree on for IBS, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Bacillus coagulans (spore-forming probiotic) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Bacillus coagulans (spore-forming probiotic) page, with its PubMed record.
Your question
Bacillus coagulans (spore-forming probiotic) and IBS
3 rows · 325 peopleThey agree: all 3 rows found an improvement.
- BGrade B× 1
- DGrade D× 2
- Rows
- 3
- Trials
- 4
- People
- 325
- Pooled reviews may count some twice
What the rows share
From the rowsThe best-graded row, grade B, is a meta-analysis of 249 people (2026) and found an improvement.
The rows run from 36 to 249 people, published from 2016 to 2026: 1 pooled review and 2 single studies.
The rows
3 improved- BGrade BIBS symptoms (Unique IS2) · Improved
Meta-analysis, 2 studies · n 249 · 2026 · 2 placebo-controlled trials of Unique IS2 in IBS: adults aged 18–60 (108 in the meta-analysis of 136 randomised) and children aged 4–12 (141)
2 billion CFU daily in adults; one chewable tablet daily in children · 8 weeks
Pooled, Unique IS2 reduced abdominal pain, bloating, urgency, incomplete evacuation, straining, flatulence, bowel-habit dissatisfaction and overall IBS symptoms, and normalised stool consistency more often than placebo; adverse effects did not differ.
Row on the Bacillus coagulans (spore-forming probiotic) page · PubMed 41682832 (opens PubMed)
- DGrade DIBS symptoms and stool consistency · Improved
RCT · n 40 · 2021 · Adults aged 18–65 with IBS (Rome IV)
6 billion CFU daily · 80 days
Digestive symptom scores (bloating/cramping, pain, diarrhoea, constipation and others) improved significantly versus placebo; 38 completed per protocol; no serious adverse events.
Row on the Bacillus coagulans (spore-forming probiotic) page · PubMed 33545934 (opens PubMed)
- DGrade DDiarrhoea-predominant IBS symptoms · Improved
Pilot RCT · n 36 · 2016 · Newly diagnosed adults with diarrhoea-predominant IBS at three centres, on standard care
2 billion CFU daily · 90 days
Bloating, vomiting, diarrhoea, abdominal pain and stool frequency fell significantly more than with placebo (p<0.01), and quality of life improved.
Row on the Bacillus coagulans (spore-forming probiotic) page · PubMed 26922379 (opens PubMed)