Akkermansia muciniphila and insulin sensitivity

What 2 graded rows on akkermansia muciniphila agree on for insulin sensitivity, and where they differ. Counted side by side, never averaged.

Consensus finder Rows from the Akkermansia muciniphila page, reviewed Oct 21, 2026 How it decides

What the rows agree on

Each block and row is one graded row from the Akkermansia muciniphila page, with its PubMed record.

Supplement

Akkermansia muciniphila Choose another

2 rows · 174 people

Split. 1 row found an improvement and 1 had mixed results.

Mixed

Improved

Each block is one evidence row, sized by how many people it enrolled, with its grade inside. Outlined: mixed results.

From the rows

The best-graded row, grade C, is a randomized trial of 142 people (2026) and reported mixed results.

The rows run from 32 to 142 people, published from 2019 to 2026: 2 single studies.

1 improved · 1 mixed

Grade DInsulin sensitivity, insulin and cholesterol in overweight insulin resistance · Improved
Pilot RCT · n 32 · 2019 · Adults with overweight or obesity and insulin resistance
10^10 bacteria/day · 3 months
Pasteurized cells improved insulin sensitivity (+28.6%) and lowered insulin (−34%) and total cholesterol (−8.7%) versus placebo; weight fell 2.3 kg (P = 0.09). Both forms were safe and well tolerated.
Row on the Akkermansia muciniphila page · PubMed 31263284 (opens PubMed)
Grade CWhole-body insulin sensitivity in metabolic syndrome · Mixed
RCT · n 142 · 2026 · Adults with metabolic syndrome, with or without prediabetes (Ireland and Germany)
30 billion cells/day · 4 months
The primary endpoint (Matsuda index) did not differ from placebo. Exploratory analyses found improvements in prediabetic, older and low-baseline-Akkermansia subgroups, including GLP-1 response.
Row on the Akkermansia muciniphila page · PubMed 42343233 (opens PubMed)