AHCC (Active Hexose Correlated Compound) and immune markers
What 3 graded rows on ahcc (active hexose correlated compound) agree on for immune markers, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the AHCC (Active Hexose Correlated Compound) page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the AHCC (Active Hexose Correlated Compound) page, with its PubMed record.
Your question
AHCC (Active Hexose Correlated Compound) and immune markers
3 rows · 95 peopleMostly an improvement: 2 of 3 rows, and most of the people. 1 found no difference.
- DGrade D× 3
- Rows
- 3
- Trials
- 3
- People
- 95
Where they differ
From the rowsThe best-graded row, grade D, is a randomized trial of 40 people (2019) and found no difference.
The 2 rows that found an improvement ran longer (4 weeks) than the row that found no difference (12 days).
Only the row that found no difference names men in its population.
The row that found no difference is newer (2019) than the 2 rows that found an improvement (2008 to 2015).
The rows
2 improved · 1 no difference- DGrade DImmune markers through early winter · Improved
RCT · n 34 · 2015 · Thirty-four healthy subjects in Japan
1.0 g a day · 4 weeks
NK cell activity rose in both groups; NK cell numbers held steady on AHCC but fell on placebo, and an immune vigor score was maintained.
Row on the AHCC (Active Hexose Correlated Compound) page · PubMed 25376719 (opens PubMed)
- DGrade DDendritic cells in healthy volunteers · Improved
RCT · n 21 · 2008 · Twenty-one healthy volunteers
3.0 g a day · 4 weeks
Total dendritic cells and the mixed-leukocyte reaction rose vs controls; NK cell activity, T-cell response and cytokines did not differ.
Row on the AHCC (Active Hexose Correlated Compound) page · PubMed 18791928 (opens PubMed)
- DGrade DImmune cells during an antibiotic course · No difference
RCT · n 40 · 2019 · 40 healthy men, 10 per arm (placebo, probiotic BB536, AHCC, or both), given azithromycin from day 7
Dose not stated in the abstract · 12 days
T-cell cytokines did not differ between groups; only the AHCC plus BB536 combination shifted dendritic cells toward myeloid types vs baseline (80% vs 61%, p = 0.006).
Row on the AHCC (Active Hexose Correlated Compound) page · PubMed 31618905 (opens PubMed)