Fucoidan
Also called fucoidans, mekabu fucoidan, wakame fucoidan, Undaria pinnatifida extract, oligo-fucoidan, low-molecular-weight fucoidan.
Best grade C across 14 graded outcomes Other Last checked
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The short answer
From 19 sourcesFucoidan trials are small and use different seaweed extracts. In 70 older Japanese adults it raised flu-vaccine antibody responses, and oligo-fucoidan improved grip strength in older adults. Blood-sugar results conflict: a 72-person Australian trial found no change in insulin resistance, while smaller trials reported shifts. Cancer trials used it alongside chemotherapy.
Quick pick
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Every graded outcome on this page
14 rows · line = participants- CGrade CQuality of life during chemoradiotherapy for rectal cancerCancer caren 87
- CGrade CTumour control and liver function in liver cancer, alongside chemoembolizationCancer caren 82
- CGrade CAntibody response to flu vaccine in older adultsVaccine responsen 70
- CGrade CBlood sugar and inflammation in prediabetesBlood sugarn 70
- CGrade CDisease control in metastatic colorectal cancer, alongside chemotherapyCancer caren 54
- DGrade DGut symptoms and bacteria during H. pylori therapyGutn 90
- DGrade DGrip strength and walking in older adultsMuscle functionn 60
- DGrade DNatural killer cell activity in healthy adultsImmune markersn 40
- DGrade DInsulin secretion, blood pressure and LDL in overweight adultsBlood sugarn 25
- DGrade DLung function and inflammation in asthmaAsthman 20
- DGrade DStrength and body composition during resistance trainingExercisen 20
- DGrade DInflammation and performance after high-intensity exerciseExercisen 16
- DGrade DMucosal immunity during intensified trainingExercisen 12
- ∅No effectInsulin resistance in obese adultsBlood sugarn 72
Key facts
- What it is
- A sulfated polysaccharide from brown seaweed; trials used mekabu, Undaria, mozuku and low-molecular-weight oligo-fucoidan28910
- Flu vaccine (70 older adults)
- 300 mg a day for 4 weeks raised antibody titres to all 3 vaccine strains vs placebo2
- Insulin resistance
- No change in the largest trial (72 obese adults, 1 g a day for 90 days)3
- Doses tested
- 300 mg to 3 g a day for 2 to 13 weeks in trials outside cancer care; 8–8.8 g a day of low-molecular-weight fucoidan for 3–6 months alongside cancer treatment21881716
- Side effects
- No adverse events reported at 3 g a day for 12 weeks (mozuku) or in a 12-week older-adult trial; adverse events matched placebo at 8.8 g a day for 6 months alongside liver-cancer treatment8916
- Drug interactions tested
- 500 mg twice daily for 3 weeks did not change blood levels of letrozole or tamoxifen in 20 women with breast cancer14
What it is
Fucoidan is a sulfated sugar chain (polysaccharide) extracted from brown seaweeds such as wakame and mozuku.
Forms, side by side
2 forms named in our sources. The rest show what our data holds, and say plainly where it holds nothing yet.
Fucoidan forms compared
2 forms| 2 forms | Undaria (wakame) or mekabu extract capsules | Mozuku fucoidan or low-molecular-weight (oligo-) fucoidan |
|---|---|---|
| Absorption in people | Human absorption was not measured in the cited trials; effects were tracked through immune and blood markers.23 | Not measured in the cited trials.8 |
| GI tolerance | Liver function tests, kidney markers and blood counts did not differ from placebo at 1 g a day for 90 days.3 | No adverse events at 3.0 g a day for 12 weeks, and none in a 12-week older-adult trial; at 8.8 g a day for 6 months adverse events matched placebo.8916 |
| Studied for | Vaccine response, insulin resistance, exercise immunity, drug-interaction (letrozole, tamoxifen) testing | NK cells, asthma, muscle function, and colorectal, rectal and liver cancer alongside standard treatment |
- Undaria (wakame) or mekabu extract capsules
- Absorption in people
- Human absorption was not measured in the cited trials; effects were tracked through immune and blood markers.23
- GI tolerance
- Liver function tests, kidney markers and blood counts did not differ from placebo at 1 g a day for 90 days.3
- Studied for
- Vaccine response, insulin resistance, exercise immunity, drug-interaction (letrozole, tamoxifen) testing
- Mozuku fucoidan or low-molecular-weight (oligo-) fucoidan
- Absorption in people
- Not measured in the cited trials.8
- GI tolerance
- No adverse events at 3.0 g a day for 12 weeks, and none in a 12-week older-adult trial; at 8.8 g a day for 6 months adverse events matched placebo.8916
- Studied for
- NK cells, asthma, muscle function, and colorectal, rectal and liver cancer alongside standard treatment
What the human research says
Human trials only, one row per outcome. The form line shows what each trial actually tested. Grades follow our evidence-grading policy.
Trial map
14 graded outcomes, largest study first14 graded outcomes: 7 improved, 5 mixed, 2 no effect. The largest, a 2023 open-label trial of 90 people on gut symptoms and bacteria during H. pylori therapy, found an improvement.
1Gut symptoms and bacteria during H. pylori therapy
Improved · Grade D · Open-label trial, 90 people, 2023
90 H. pylori-positive patients in China, three groups
Dose, result and source| Outcome | Found | People | Study | Who was studied |
|---|---|---|---|---|
| Gut symptoms and bacteria during H. pylori therapy | Improved | 90 | Grade D · Open-label trial, 2023 | 90 H. pylori-positive patients in China, three groups |
| Quality of life during chemoradiotherapy for rectal cancer | Mixed | 87 | Grade C · RCT, 2023 | Adults with locally advanced rectal cancer receiving chemoradiotherapy before surgery in Taiwan (44 fucoidan, 43 placebo) |
| Tumour control and liver function in liver cancer, alongside chemoembolization | Improved | 82 | Grade C · RCT, 2025 | Adults with unresectable hepatocellular carcinoma receiving transarterial chemoembolization (TACE) in China |
| Insulin resistance in obese adults | No effect | 72 | No-effect grade · RCT, 2019 | Obese adults without diabetes in Tasmania (35 fucoidan, 37 placebo) |
| Blood sugar and inflammation in prediabetes | Improved | 70 | Grade C · RCT, 2025 | 70 Chinese adults with prediabetes |
| Antibody response to flu vaccine in older adults | Improved | 70 | Grade C · RCT, 2013 | 70 Japanese volunteers over 60 years |
| Grip strength and walking in older adults | Improved | 60 | Grade D · RCT, 2026 | 60 community-dwelling adults aged 60 or over, split into three groups |
| Disease control in metastatic colorectal cancer, alongside chemotherapy | Mixed | 54 | Grade C · RCT, 2017 | 54 Taiwanese patients with metastatic colorectal cancer (28 fucoidan, 26 control) |
| Natural killer cell activity in healthy adults | Improved | 40 | Grade D · Pilot RCT, 2021 | Healthy Japanese adults (20 fucoidan, 20 placebo) |
| Insulin secretion, blood pressure and LDL in overweight adults | Mixed | 25 | Grade D · RCT, 2014 | 25 overweight or obese volunteers in Mexico (13 fucoidan, 12 placebo) |
| Strength and body composition during resistance training | Mixed | 20 | Grade D · RCT, 2025 | Healthy adults (9 men, 11 women) starting a 6-week resistance training programme |
| Lung function and inflammation in asthma | Improved | 20 | Grade D · RCT, 2022 | 20 adults with asthma on regular treatment |
| Inflammation and performance after high-intensity exercise | No effect | 16 | Grade D · Crossover RCT, 2023 | 8 men and 8 women |
| Mucosal immunity during intensified training | Mixed | 12 | Grade D · Crossover RCT, 2023 | 12 recreationally active men |
Every graded row
14 rowsShowing 14 of 14 outcomes. Human trials only.
CGrade CQuality of life during chemoradiotherapy for rectal cancerCancer careLess rash and fatigueRCT
n 87 · 2023
Mixed Physical well-being scores were better at 2 and 3 months, but the overall colorectal quality-of-life score (FACT-C) did not differ. Skin rash, itching and fatigue were less common with fucoidan (P < .05).
- Design
- RCT, n = 87, 2023
- Population
- Adults with locally advanced rectal cancer receiving chemoradiotherapy before surgery in Taiwan (44 fucoidan, 43 placebo)
- Form
- Low-molecular-weight fucoidan powder (from Sargassum hemiphyllum)
- Dose
- 4 g twice daily (8 g/day)
- Duration
- 3 months
- Source
- Reference 17 · PubMed 37822243 (opens PubMed)
CGrade CTumour control and liver function in liver cancer, alongside chemoembolizationCancer careDisease control 95% vs 80%RCT
n 82 · 2025
Improved Disease control rate 95.24% vs 80.00% (p = 0.035); objective response 52.38% vs 35.00% (not significant). More patients kept Child-Pugh class A liver function (80.95% vs 62.50%; p = 0.029). Adverse event rates were similar; no severe events.
- Design
- RCT, n = 82, 2025
- Population
- Adults with unresectable hepatocellular carcinoma receiving transarterial chemoembolization (TACE) in China
- Form
- Low-molecular-weight fucoidan powder (from Laminaria japonica)
- Dose
- 4.4 g twice daily (8.8 g/day)
- Duration
- 6 months
- Source
- Reference 16 · PubMed 40960276 (opens PubMed)
CGrade CAntibody response to flu vaccine in older adultsVaccine responseHigher flu antibodiesRCT
n 70 · 2013
Improved Antibody titres against all 3 vaccine strains were higher than placebo; the B-strain response met EU licensure criteria with fucoidan (titre ratio 2.4) but not placebo (1.7); NK cell activity tended to rise (P = 0.08).
- Design
- RCT, n = 70, 2013
- Population
- 70 Japanese volunteers over 60 years
- Form
- Mekabu fucoidan (a seaweed extract)
- Dose
- 300 mg a day
- Duration
- 4 weeks before vaccination
- Source
- Reference 2 · PubMed 24005608 (opens PubMed)
CGrade CBlood sugar and inflammation in prediabetesBlood sugarModest glucose and inflammation changesRCT
n 70 · 2025
Improved Glycated serum protein rose less and TNF-α, IL-6 and LPS fell compared with placebo (P < 0.05); Megamonas and Blautia rose and Klebsiella fell in the gut.
- Design
- RCT, n = 70, 2025
- Population
- 70 Chinese adults with prediabetes
- Form
- Fucoidan capsules
- Dose
- 1000 mg a day
- Duration
- 12 weeks
- Source
- Reference 7 · PubMed 39645105 (opens PubMed)
CGrade CDisease control in metastatic colorectal cancer, alongside chemotherapyCancer careDisease control up; survival sameRCT
n 54 · 2017
Mixed Disease control rate 92.8% vs 69.2% (p = 0.026); overall survival, progression-free survival, response rate, adverse effects and quality of life did not differ.
- Design
- RCT, n = 54, 2017
- Population
- 54 Taiwanese patients with metastatic colorectal cancer (28 fucoidan, 26 control)
- Form
- Low-molecular-weight fucoidan with chemo-target agents
- Dose
- Dose not stated in the abstract
- Duration
- Median follow-up 11.5 months
- Source
- Reference 5 · PubMed 28430159 (opens PubMed)
DGrade DGut symptoms and bacteria during H. pylori therapyGutFewer symptomsOpen-label trial
n 90 · 2023
Improved Adding fucoidan improved gastrointestinal symptoms and kept Bifidobacterium from falling; given before therapy it raised beneficial bacteria most. Eradication rates are not given in the abstract.
- Design
- Open-label trial, n = 90, 2023
- Population
- 90 H. pylori-positive patients in China, three groups
- Form
- Fucoidan with or before standard quadruple therapy
- Dose
- Dose not stated in the abstract
- Duration
- Up to 12 weeks
- Source
- Reference 11 · PubMed 37548312 (opens PubMed)
DGrade DGrip strength and walking in older adultsMuscle functionBetter grip strengthRCT
n 60 · 2026
Improved Grip strength improved with oligo-fucoidan (p < 0.001; effect size r = 0.82) as did 6-minute walk distance (p < 0.001); muscle mass did not change; no adverse events.
- Design
- RCT, n = 60, 2026
- Population
- 60 community-dwelling adults aged 60 or over, split into three groups
- Form
- Low-molecular-weight oligo-fucoidan (a third group added BCAAs and vitamin D)
- Dose
- Dose not stated in the abstract
- Duration
- 12 weeks
- Source
- Reference 9 · PubMed 41124892 (opens PubMed)
DGrade DNatural killer cell activity in healthy adultsImmune markersNK activity up in menPilot RCT
n 40 · 2021
Improved NK cell activity rose at 8 weeks compared with before; versus placebo the rise was significant only in men; no adverse events.
- Design
- Pilot RCT, n = 40, 2021
- Population
- Healthy Japanese adults (20 fucoidan, 20 placebo)
- Form
- Okinawa mozuku (Cladosiphon okamuranus) fucoidan beverage
- Dose
- 3.0 g a day
- Duration
- 12 weeks
- Source
- Reference 8 · PubMed 34203925 (opens PubMed)
DGrade DInsulin secretion, blood pressure and LDL in overweight adultsBlood sugarMixed changesRCT
n 25 · 2014
Mixed Diastolic blood pressure (71.7 to 67.8 mmHg) and LDL cholesterol (3.1 to 2.7 mmol/l) fell, while insulin, HOMA beta-cell and HOMA-IR (1.9 to 2.6) rose after fucoidan.
- Design
- RCT, n = 25, 2014
- Population
- 25 overweight or obese volunteers in Mexico (13 fucoidan, 12 placebo)
- Form
- Fucoidan
- Dose
- 500 mg once daily before breakfast
- Duration
- 3 months
- Source
- Reference 4 · PubMed 24611906 (opens PubMed)
DGrade DLung function and inflammation in asthmaAsthmaSmall lung-function gainRCT
n 20 · 2022
Improved FEV1/FVC rose (p = 0.046) and WBC and IL-8 fell with oligo-fucoidan, while IFN+ and CD4+IFN+ cells rose, compared with placebo on top of usual asthma care.
- Design
- RCT, n = 20, 2022
- Population
- 20 adults with asthma on regular treatment
- Form
- Oligo-fucoidan
- Dose
- Dose not stated in the abstract
- Duration
- 24 weeks
- Source
- Reference 6 · PubMed 36307493 (opens PubMed)
DGrade DStrength and body composition during resistance trainingExerciseStrength same; lean mass upRCT
n 20 · 2025
Mixed Back-squat strength rose in both groups with no treatment effect (p = 0.48); Wingate peak power rose in the fucoidan group only, and lean mass rose and body fat fell with fucoidan (treatment effect p < 0.05).
- Design
- RCT, n = 20, 2025
- Population
- Healthy adults (9 men, 11 women) starting a 6-week resistance training programme
- Form
- Fucoidan blend (Undaria pinnatifida and Fucus vesiculosus)
- Dose
- 1 g a day
- Duration
- 6 weeks
- Source
- Reference 19 · PubMed 41249370 (opens PubMed)
DGrade DInflammation and performance after high-intensity exerciseExerciseNo performance changeCrossover RCT
n 16 · 2023
No effect Sprint peak and mean power did not change; IL-6 and IL-10 were higher 30 minutes after exercise with fucoidan, and other blood markers did not differ. No adverse events.
- Design
- Crossover RCT, n = 16, 2023
- Population
- 8 men and 8 women
- Form
- Undaria pinnatifida fucoidan
- Dose
- 1 g a day
- Duration
- 2 weeks per arm
- Source
- Reference 18 · PubMed 37331983 (opens PubMed)
DGrade DMucosal immunity during intensified trainingExerciseMostly nullCrossover RCT
n 12 · 2023
Mixed Training gains (16-19% mean power) did not differ; resting faecal and salivary markers were stable, but the salivary IgA response to exercise was about 2.7-fold higher (p = 0.02).
- Design
- Crossover RCT, n = 12, 2023
- Population
- 12 recreationally active men
- Form
- Undaria pinnatifida extract with more than 85% fucoidan
- Dose
- 1 g a day
- Duration
- 3 weeks per arm
- Source
- Reference 10 · PubMed 38247026 (opens PubMed)
∅No effectInsulin resistance in obese adultsBlood sugarNo changeRCT
n 72 · 2019
No effect No differences in any 90-day outcome; mean HOMA change was 0 on placebo and -0.1 on fucoidan (p = 0.73).
- Design
- RCT, n = 72, 2019
- Population
- Obese adults without diabetes in Tasmania (35 fucoidan, 37 placebo)
- Form
- Fucoidan extract capsules
- Dose
- 500 mg twice daily
- Duration
- 90 days
- Source
- Reference 3 · PubMed 30312135 (opens PubMed)
What the numbers add up to
Each point is worked out from the data and the sources numbered on this page, with the arithmetic shown under it. It adds no new data and is not medical advice.
Same name, different molecules
Blood sugar: the biggest trial was null
Studied doses
Doses used in research, shown against the official limits. They describe the studies, not a recommendation for you.
Studied doses in research, not advice. These are amounts used in research, not personal advice. Your clinician or pharmacist can say what fits you.
Doses studied in human trials
Interactions and safety
Published interactions only: each row cites a source. No row means none was found in our sources, not that a combination is safe.
What Fucoidan meets
2 cited rows 3 tested togetherMedicines 2
Supplements and foods 3
- Measured in a human study
- Tested together in a graded trial
Choose a medicine or supplement above to read its cited rows here.
Also cited: 3 tested together
Blood thinners and antiplatelet medicines
RCTMeasured in a human study
Blood thinners and antiplatelet medicines, for example warfarin, aspirin, clopidogrel: In volunteers, 400 mg a day of Laminaria fucoidan for 5 weeks shortened clot lysis time and raised prostacyclin, a platelet inhibitor. No study has tested fucoidan with blood thinners, so the combined effect on bleeding is unknown.
Source 15, Br J Nutr (2013)
Letrozole and tamoxifen
PK studyMeasured in a human study
Letrozole and tamoxifen, for example breast cancer hormone therapy: No change in steady-state blood levels of letrozole, tamoxifen or its active metabolites after 3 weeks of Undaria fucoidan 500 mg twice daily (10 patients per drug); no adverse effects. The fucoidan maker employed one author.
Source 14, Integr Cancer Ther (2018)
BCAAsBCAAs page
Tested together
Grip strength and walking in older adults. Graded on the Fucoidan page; tested together is not a claim that they work better together.
FucoxanthinFucoxanthin page
Tested together
Liver enzymes and fat in fatty liver disease (fucoidan + fucoxanthin). Graded on the Fucoxanthin page; tested together is not a claim that they work better together.
Vitamin D3 vs D2Vitamin D3 vs D2 page
Tested together
Grip strength and walking in older adults. Graded on the Fucoidan page; tested together is not a claim that they work better together.
Interactions
2 agents| Agent | What the source says | Evidence |
|---|---|---|
| Medicines2 | ||
| Letrozole and tamoxifene.g. breast cancer hormone therapy | No change in steady-state blood levels of letrozole, tamoxifen or its active metabolites after 3 weeks of Undaria fucoidan 500 mg twice daily (10 patients per drug); no adverse effects. The fucoidan maker employed one author.14 | PK study |
| Blood thinners and antiplatelet medicinese.g. warfarin, aspirin, clopidogrel | In volunteers, 400 mg a day of Laminaria fucoidan for 5 weeks shortened clot lysis time and raised prostacyclin, a platelet inhibitor. No study has tested fucoidan with blood thinners, so the combined effect on bleeding is unknown.15 | RCT |
Check with what you take
Kept on this device onlyAdd what you take. We list every interaction our evidence profiles cite between Fucoidan and your picks, and between your picks.
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Add a supplement or medicine you take to check it against Fucoidan.
Starting from one medicine? The interaction checker rates how serious each pair is, on a curated list of 19 entries for 11 medicines. This cabinet has no severity rating: it lists every interaction row our supplement pages cite.
Who should be careful
5 groups- Pregnancy, breastfeeding and children
- No trial here enrolled pregnant or breastfeeding people or children, and NCCIH notes many supplements are untested in these groups. LactMed's seaweed record finds no data on organic seaweed components in milk, but iodine and heavy metals from seaweed pass into breast milk.112
- Bleeding risk and surgery
- Fucoidan shortened clot lysis time in a 5-week volunteer study. NCCIH advises telling your health care providers about every supplement, especially before surgery or with blood-thinning medicines.151
- Liver
- LiverTox has no fucoidan record; its kelp record (kelp contains fucoidan) rates kelp E, an unlikely cause of liver injury. Liver tests did not differ from placebo at 1 g a day for 90 days.133
- Thyroid conditions
- Whole kelp and seaweed are rich in iodine and in large amounts can harm people with thyroid conditions (LiverTox). No fucoidan trial here measured thyroid function.13
How to read the label
What to check on the Supplement Facts panel.
How to read the label
1 checksWhere to buy Fucoidan
Products from brands we partner with that contain Fucoidan. Check the amount per serving against the doses studied above, and the label for other ingredients.
Fucoidan products from partner brands
1 product Paid links · we earn a commission- Quick pickHerbsProLife Extension Optimized Fucoidan With Maritech, 60 Veg Caps
1 capsule: 88.5 mg Maritech 926 Undaria pinnatifida extract standardised to 85% fucoidan (75 mg); trials used 300 mg to 3 g a day
$27.00one-timeChecked Oct 15, 2026
Frequently asked questions
Short answers to common questions; the numbers link to the sources below.
Common questions
6 answersDoes fucoidan boost immunity?
Does fucoidan help blood sugar?
Does fucoidan help muscle or exercise performance?
Evidence is thin and mixed. In older adults, oligo-fucoidan improved grip strength over 12 weeks. In young adults, 1 g a day did not add strength during 6 weeks of resistance training (though lean mass rose in 10 people), did not change sprint power after 2 weeks, and did not change 3-week training gains.9191810
Does fucoidan affect blood clotting?
Possibly. In volunteers, 400 mg a day of Laminaria fucoidan for 5 weeks shortened the time to break down a clot and raised prostacyclin, which damps platelet activity. No trial has tested fucoidan with blood thinners, so tell your clinician if you use both or before surgery.15
Is fucoidan safe?
No adverse events were reported in 12-week trials at up to 3 g a day, and adverse events matched placebo at 8.8 g a day for 6 months. LiverTox rates kelp, which contains fucoidan, an unlikely cause of liver injury. Fucoidan may affect clotting, so mention it before surgery or with blood thinners.89161315
Is fucoidan used with cancer treatment?
Only in trials alongside standard care. Low-molecular-weight fucoidan raised disease control with chemotherapy (54 patients) and with liver chemoembolization (82 patients; 95% vs 80%), and cut rash and fatigue during rectal chemoradiotherapy (87 patients), but survival did not differ where reported. All three involved the same Taiwanese maker, Hi-Q Marine Biotech.51617
Sources
19 sources: trial abstracts, NIH fact sheets and reference databases. Numbers in the text link here.
Sources cited on this page
19 sources- 1Using Dietary Supplements WiselyFact sheet National Center for Complementary and Integrative Health (NCCIH), 2019 · nccih.nih.gov
- 2Supplementation of elderly Japanese men and women with fucoidan from seaweed increases immune responses to seasonal influenza vaccination.RCT J Nutr, 2013 · PMID 24005608
- 3Effect of a Fucoidan Extract on Insulin Resistance and Cardiometabolic Markers in Obese, Nondiabetic Subjects: A Randomized, Controlled Trial.RCT J Altern Complement Med, 2019 · PMID 30312135
- 4Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults.RCT J Med Food, 2014 · PMID 24611906
- 5Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial.RCT Mar Drugs, 2017 · PMID 28430159
- 6Effects of oligo-fucoidan on the immune response, inflammatory status and pulmonary function in patients with asthma: a randomized, double-blind, placebo-controlled trial.RCT Sci Rep, 2022 · PMID 36307493
- 7Effect of fucoidan supplementation on glycolipid metabolism, systemic inflammation and gut microbiota in prediabetes: A randomized controlled trial.RCT Int J Biol Macromol, 2025 · PMID 39645105
- 8Effects of Ingesting Fucoidan Derived from Cladosiphon okamuranus Tokida on Human NK Cells: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Pilot Study.Pilot RCT Mar Drugs, 2021 · PMID 34203925
- 9The effects of Oligo-Fucoidan on muscle function in community-dwelling older adults: A double-blind, randomized, placebo-controlled trial.RCT Arch Gerontol Geriatr, 2026 · PMID 41124892
- 10Immunomodulatory effects of fucoidan in recreationally active adult males undertaking 3-weeks of intensified training.Crossover RCT J Sports Sci, 2023 · PMID 38247026
- 11Effect of fucoidan on gut microbiota and its clinical efficacy in Helicobacter pylori eradication: A randomized controlled trial.Open-label trial J Dig Dis, 2023 · PMID 37548312
- 12SeaweedDatabase LactMed (NCBI Bookshelf), 2024 · ncbi.nlm.nih.gov
- 13KelpDatabase LiverTox (NCBI Bookshelf), 2024 · ncbi.nlm.nih.gov
- 14The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer.PK study Integr Cancer Ther, 2018 · PMID 28008779
- 15Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects.RCT Br J Nutr, 2013 · PMID 23374164
- 16Fucoidan Improves Tumour Control and Liver Function in TACE for Unresectable Hepatocellular Carcinoma: A Randomised Trial.RCT Liver Int, 2025 · PMID 40960276
- 17The Auxiliary Effects of Low-Molecular-Weight Fucoidan in Locally Advanced Rectal Cancer Patients Receiving Neoadjuvant Concurrent Chemoradiotherapy Before Surgery: A Double-Blind, Randomized, Placebo-Controlled Study.RCT Integr Cancer Ther, 2023 · PMID 37822243
- 18Effects of fucoidan supplementation on inflammatory and immune response after high-intensity exercise.Crossover RCT J Int Soc Sports Nutr, 2023 · PMID 37331983
- 19Investigating fucoidan blend supplementation and resistance training in humans: a parallel randomized controlled trial design.RCT Sci Rep, 2025 · PMID 41249370
What changed
Every dated change to this page: what changed, who made it and why.
Change log
2 entries| Date | Change | Who and why |
|---|---|---|
| all | Audit update. PubMed search for fucoidan trials through 2026: added rows for a 2025 liver-cancer chemoembolization trial and a 2023 rectal-cancer chemoradiotherapy trial (both marked as supervised medical uses, as is now the 2017 colorectal chemotherapy row), a 2023 high-intensity exercise crossover and a 2025 resistance-training trial. Added interactions: a 2018 pharmacokinetic study (no change in letrozole or tamoxifen levels) and a clotting caution from a 2013 volunteer study. Added LactMed (seaweed) breastfeeding data, a LiverTox (kelp) liver note, thyroid, bleeding and cancer-care notes, two FAQ items (replacing 'What is fucoidan?', which the page already answers), page questions and the immune hub link. A 2024 pain meta-analysis was not added (mostly preclinical). | Writer: Kymata Health EditorialTrigger: A–Z audit against docs/supplements/AUDIT-STANDARD.md |
| all | Initial editorial evidence review. Every PMID checked against NCBI E-utilities esummary (title, year, journal; none retracted) and each cited abstract read; numbers taken from the abstracts (full text used only where noted for participant counts or funding). Funding disclosed per study: Marinova Pty. Ltd. (2019 insulin trial; 2023 training trial per Europe PMC), Hi-Q Marine Biotech (asthma trial; academia-industry cooperation in the colorectal trial, full text), South Product (mozuku NK pilot), Chinese public and university grants (H. pylori trial), I-Shou and National Cheng Kung universities (older-adult trial, Europe PMC); the other abstracts name no funder (disclosed as not stated). No fucoidan-specific page exists on our approved safety sources, so safety rows use only NCCIH's general supplement guidance. Where to buy: Life Extension Optimized Fucoidan With Maritech (label checked 2026-10-15). | Writer: Kymata Health EditorialTrigger: new page |
Supplement & Nutrient Encyclopedia. Educational information only; it is not medical advice and does not replace a clinician. Dietary supplements are not intended to diagnose, treat, cure or prevent any disease. Statements about supplements have not been evaluated by the FDA.