Centenarian Decathlon Prep
Healthspan stack for muscle, cartilage, and VO2: Gotratix, Sigumir, Ventfort, plus MOTS-c. Inspired by Attia's marginal-decade idea, not a guarantee you die at 50 in a gym.
Duration
20-30 day oral courses, repeated; MOTS-c weekly during a block
First reports
Training quality in weeks; joint comfort is slow
SKUs on this map
4
1Overview
A chassis of muscle, cartilage, and vascular cytomax plus a mitochondrial peptide. Rapamycin and 4 g omega-3s are mentioned as lifestyle/Rx adjacent, not as SKUs we sell. The work is still the decathlon: carry, hike, get off the floor.
Ideal Candidates
Contraindications
2The Science
Sarcopenia, cartilage wear, and vascular stiffness are the failure modes Attia popularized as the Centenarian Decathlon. Gotratix (muscle), Sigumir (cartilage), Ventfort (vessels) are the Khavinson leaves Atlas puts under that headline. MOTS-c is the "exercise-adjacent" peptide. None of them replace progressive resistance training.
3Clinical Evidence
Key Findings
VO2 max and strength are among the best-validated healthspan predictors; peptides here are optional overlays
MOTS-c has mechanistic and animal performance data; human "decathlon" trials named that way do not exist
Study Limitations
- ⚠Attia's framework is clinical philosophy, not a Khavinson RCT.
- ⚠High-dose omega-3 and rapamycin are not peptide library leaves.
4The Peptide Stack
Gotratix
View Profile →Muscle cytomax aimed at myocytes and, in marketing language, Type II fiber retention. Judge it as an adjunct to lifting.
Mechanism: Oral muscle complex; empty stomach.
Sigumir
View Profile →Cartilage/bone cytomax. Joint armor is still load management plus physio.
Mechanism: Oral musculoskeletal complex.
Ventfort
View Profile →Vascular compliance story for the VO2 side of the decathlon.
Mechanism: Oral vascular complex.
MOTS-c
View Profile →Weekly mitochondrial peptide, often timed before Zone 2 in community use.
Mechanism: Mitochondrial-encoded; not a license to skip the hike.
Where to get the bioregulators in this protocol
Vita-Stream, our affiliate partner, sells the oral bioregulators this protocol names (Gotratix, Sigumir and Ventfort). Each button opens that exact product page.
Vita-Stream links are affiliate links: Kymata Health earns a commission at no extra cost to you. Supplement statements have not been evaluated by the FDA; not intended to diagnose, treat, cure, or prevent any disease. Full review
5Protocol Tiers
Tier 1: Chassis (muscle, cartilage, vessels)
Gotratix + Sigumir + Ventfort daily during the course. Repeat a few times per year.
Tier 2: MOTS-c + Zone 2
One mitochondrial peptide, four Zone 2 sessions. The peptide is optional; the sessions are not.
6Lifestyle Integration
Lifestyle notes that travel with these SKUs. Not a prescription and not required for the math to be valid.
Training
Zone 2 plus 2-3 full-body strength sessions. Practice the movements you want at 90: floor, carry, hike, stairs.
Nutrition
Protein at every meal you can. 4 g EPA/DHA is a common longevity target; check your actual capsules, most are underdosed.
Sleep
Recovery is the other half of the decathlon.
Stress Management
Rapamycin is prescription autophagy chemistry. We will not dose it here.
7Timeline & Expectations
Weeks 1-4
Weeks 5-12
Off course
8Monitoring & Safety
Key Metrics to Track
Troubleshooting
Knees worse after adding MOTS-c and extra running
- Too much volume
- Peptide blamed for programming
- Cut running, keep strength
- Physio before another vial
I skipped lifting because I bought Gotratix
- Wrong job-to-be-done
- Lift. Then optionally run the course.
9Further Reading
Dive deeper into the individual peptides and methodologies behind this protocol.
MOTS-c: The Mitochondrial Peptide That Mimics Exercise at the Cellular Level
MOTS-c is a mitochondria-derived peptide that activates AMPK, enhances insulin sensitivity, and replicates the metabolic effects of exercise. Complete guide to mechanism, dosing, and evidence.
Read article →Peptides for Joint Pain & Knee Cartilage Repair: BPC-157, TB-500 & Beyond
Using BPC-157, TB-500, and GHK-Cu for knee pain, cartilage repair, and joint inflammation - protocols, evidence, and stacking.
Read article →Epitalon: telomerase papers vs what vendors claim
The definitive guide to Epitalon - telomerase activation via TERT gene expression, Khavinson's bioregulation theory, 5 peer-reviewed studies with PMIDs, dosing protocols, and a comparison with MOTS-c and SS-31.
Read article →