Cetrorelix
Cetrotide · cetrorelix acetate
GnRH antagonist FDA-approved to prevent premature LH surge in controlled ovarian stimulation. Cetrotide 0.25 mg is a lyophilized vial plus 1 mL sterile water in a prefilled syringe - mix and inject the contents. First dose is supposed to happen under medical supervision (anaphylaxis risk). This is a clinic kit, not a research-chem analog.
Quick answer
What it is: GnRH antagonist FDA-approved to prevent premature LH surge in controlled ovarian stimulation.
Typical research dose: 0.25 mg SC once daily (Cetrotide kit) until hCG trigger
Research summary, not medical advice.
Use-case scores
- Sexual / hormonal7/10
Compound card
- Class
- GnRH antagonist (Cetrotide IVF kit)
- Formula
- Cetrorelix acetate (decapeptide antagonist)
- Status
- FDA-approved
How it works
Cetrorelix is a GnRH-receptor antagonist. Cetrotide 0.25 mg is a lyophilized vial plus 1 mL sterile water in a prefilled syringe. Reconstitute with the supplied solvent, swirl (do not shake), inject the contents SC. First injection under medical supervision - anaphylaxis is a labeled risk.
Single 0.25 mg t½ ~5 hours; repeat daily dosing lengthens apparent t½. The 3 mg single-dose regimen is a different kit.
Source: Cetrotide PI (EMD Serono); DailyMed cetrorelix acetate
Use the kit solvent. Inject the vial.
Labeled math is 0.25 mg in 1 mL. You are not titrating mcg on an insulin syringe for the 0.25 mg kit - you deliver the reconstituted contents. Research bulk powder is a different product; this page defaults to the Cetrotide kit.
Research Use Cases
- ✓IVF LH-surge blockade: High
Dosing
| Phase | Dose | Frequency | Notes |
|---|---|---|---|
| Cetrotide 0.25 mg (labeled multiple-dose) | 0.25 mg SC | Once daily from stim day 5 or 6 until hCG | IVF only, specialist-prescribed. |
Administration
Timeline
Who it is for
IVF LH-surge blockade
HighThis is the labeled job. Not a research-chem GnRH toy.
Reconstitution
| Vial | Water | Concentration | Example dose |
|---|---|---|---|
| 0.25 mg lyophilized | 1 mL BAC | 0.25 mg/mL | 0.25 mg + 1 mL from the kit. Inject the contents. Not a multi-dose research cake. |
Change vial size or water volume? Open the reconstitution calculator.
Safety & Considerations
Prescription. Pregnancy contraindicated. Hypersensitivity including anaphylaxis. OHSS is a stimulation-cycle risk. First dose supervised.
Regulatory & Legal Status
FDA-approved as Cetrotide® for prevention of premature LH surge in COS/IVF
Competitive athletes subject to anti-doping controls should not use Cetrorelix.
Prescription Drug
US Compounding: Not eligible / not available
⚠️ This information is for educational purposes only and may not reflect the most current regulatory updates. Always verify with official FDA, WADA, and jurisdiction-specific sources before use.
Limits of current evidence
- This site will not run IVF from a peptide page.
Verdict
Cetrorelix is Cetrotide. Mix the 0.25 mg kit as the insert says. First-dose anaphylaxis monitoring is on the label. Not a research-chem GnRH analog for gym use.
Interactions & Contraindications
Prescription. Pregnancy contraindicated. Hypersensitivity including anaphylaxis. OHSS is a stimulation-cycle risk. First dose supervised.
Frequently Asked Questions
How much water for Cetrotide 0.25 mg?▼
Can I split the vial across days?▼
References
- EMD Serono “Cetrotide (cetrorelix acetate) prescribing information.” US PI (current).
Prescription options: compare licensed telehealth providers
Some peptide therapies are available only by prescription after a consult with a licensed clinician.