Whole coffee fruit extract and cognition
What 4 graded rows on whole coffee fruit extract agree on for cognition, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Whole coffee fruit extract page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Whole coffee fruit extract page, with its PubMed record.
Your question
Whole coffee fruit extract and cognition
4 rows · 399 peopleSplit. 1 row found an improvement, 1 found no difference and 2 had mixed results.
- DGrade D× 4
- Rows
- 4
- Trials
- 4
- People
- 399
Where they differ
From the rowsThe best-graded row, grade D, is a randomized trial of 196 people (2024) and reported mixed results.
The row that found an improvement is newer (2026) than the row that found no difference (2023).
2 rows with mixed results are left out of this comparison.
The rows
1 improved · 1 no difference · 2 mixed- DGrade DComposite memory score in suspected mild cognitive impairment · Improved
RCT · n 60 · 2026 · Japanese adults aged 40 and over with suspected mild cognitive impairment (66 randomised)
High dose supplying 20 mg/day dimeric procyanidins; low dose 5 mg/day · 12 weeks
The composite memory score was 12.1 points higher than placebo with the high dose (P = 0.038); the low dose did not differ. No adverse events.
Row on the Whole coffee fruit extract page · PubMed 42302880 (opens PubMed)
- DGrade DAcute cognition, mood and energy · No difference
Crossover RCT · n 72 · 2023 · Healthy adults aged 18–49
100 mg or 300 mg single dose (75 mg caffeine as positive control) · Single doses, tested at 60 and 120 minutes
No effect of 300 mg; 100 mg increased mental fatigue and lowered sustained-attention accuracy at 60 minutes versus placebo.
Row on the Whole coffee fruit extract page · PubMed 37299382 (opens PubMed)
- DGrade DWorking memory and response inhibition (acute and 28 days) · Mixed
RCT · n 196 · 2024 · Generally healthy US adults aged 40–65, tested remotely (196 in the Go/No-Go and 142 in the n-back analyses)
200 mg/day · 28 days, plus an acute test 1 hour after the first dose
After the first dose CCE reduced omissions and improved accuracy on working-memory and inhibition tasks versus placebo; over 28 days it beat placebo on one accuracy measure only.
Row on the Whole coffee fruit extract page · PubMed 39064791 (opens PubMed)
- DGrade DReaction time and accuracy in mild cognitive decline · Mixed
RCT · n 71 · 2020 · Adults with mild cognitive decline
Three CCE regimens, morning or twice daily (amounts not stated in the abstract) · 28 days
Reaction times fell versus placebo from baseline to days 7 and 28 (p = 0.040); no main effect on accuracy, with trends in two of three CCE groups.
Row on the Whole coffee fruit extract page · PubMed 31829793 (opens PubMed)