Vitamin D3 vs D2 and healthy aging
What 2 graded rows on vitamin d3 vs d2 agree on for healthy aging, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Vitamin D3 vs D2 page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Vitamin D3 vs D2 page, with its PubMed record.
Your question
Vitamin D3 vs D2 and healthy aging
2 rows · 28,028 peopleThey agree: both rows found no difference.
- ∅No effect× 2
- Rows
- 2
- Trials
- 2
- People
- 28,028
What the rows share
From the rowsEvery row is graded No effect, our grade for adequately powered trials that found no effect.
The rows run from 2,157 to 25,871 people, published from 2019 to 2020: 2 single studies.
The rows
2 no difference- ∅No effectMajor health events in healthy older adults (VITAL primary end points) · No difference
RCT · n 25,871 · 2019 · US men 50+ and women 55+, not selected for deficiency (VITAL)
2,000 IU/day · Median 5.3 years
No lower incidence of invasive cancer (HR 0.96) or major cardiovascular events (HR 0.97) vs placebo. Cancer death HR 0.83 (95% CI 0.67–1.02, not significant). No excess hypercalcemia.
Row on the Vitamin D3 vs D2 page · PubMed 30415629 (opens PubMed)
- ∅No effectBlood pressure, physical function, thinking, fractures and infections in adults 70+ (DO-HEALTH) · No difference
RCT · n 2,157 · 2020 · Adults 70 and older with no major health events in the prior 5 years, sufficient mobility and good cognition
2,000 IU/day · 3 years
Vitamin D3 did not improve any of the 6 primary outcomes: systolic or diastolic blood pressure, physical performance, cognition, nonvertebral fractures or infection rates (systolic difference −0.8 mmHg, 99% CI −2.1 to 0.5).
Row on the Vitamin D3 vs D2 page · PubMed 33170239 (opens PubMed)