Vitamin D3 vs D2 and fractures
What 2 graded rows on vitamin d3 vs d2 agree on for fractures, and where they differ. Counted side by side, never averaged.
Consensus finder Rows from the Vitamin D3 vs D2 page, reviewed Oct 21, 2026 How it decides
What the rows agree on
Each block and row is one graded row from the Vitamin D3 vs D2 page, with its PubMed record.
Your question
Vitamin D3 vs D2 and fractures
2 rows · 112,371 peopleThey agree: both rows found no difference.
- ∅No effect× 2
- Rows
- 2
- Trials
- 2
- At least: a review without a trial count
- People
- 112,371
- Pooled reviews may count some twice
What the rows share
From the rowsEvery row is graded No effect, our grade for adequately powered trials that found no effect.
The rows run from 20,326 to 92,045 people, published from 2023 to 2026: 1 pooled review and 1 single study.
The rows
2 no difference- ∅No effectFractures and falls (2026 meta-analysis) · No difference
Meta-analysis · n 92,045 · 2026 · 36 randomized trials of vitamin D alone in adults not on osteoporosis drugs, mostly community dwelling
Varied across trials · Varied across trials
Vitamin D alone did not change the risk of any fracture (RR 1.00, 95% CI 0.95 to 1.06; high certainty). Vitamin D with calcium gave RR 0.91 (0.84 to 0.99; 15 trials, 51,126 people), which the authors judged little to no benefit in absolute terms. Falls and other fracture outcomes showed little to no effect.
Row on the Vitamin D3 vs D2 page · PubMed 42161415 (opens PubMed)
- ∅No effectFractures with monthly doses (D-Health) · No difference
RCT · n 20,326 · 2023 · Adults 60 to 84 in Australia, not screened for vitamin D status
60,000 IU once a month · Up to 5 years (median follow-up 5.1 years)
568 (5.6%) on vitamin D and 603 (5.9%) on placebo had a fracture (HR 0.94, 95% CI 0.84 to 1.06). Hip fracture HR 1.11 (0.86 to 1.45). Monthly doses did not raise fracture risk.
Row on the Vitamin D3 vs D2 page · PubMed 37011645 (opens PubMed)